The meta-analysis revealed substantial between-study variance (Tau2 = 684.19) and a highly significant Chi-squared test for heterogeneity (Chi2 = 330.07, p < 0.00001), indicating that the variation in effect estimates was predominantly attributable to differences among studies rather than sampling error.
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The detected linkage disequilibrium was highly significant in both cases (P<10 −5 ).
The results showed that the effect size of connectivity difference remained highly significant: BNM—L Precentral Gyrus ( p < 0.00001); BNM—R Precentral Gyrus ( p < 0.00002); LC—Cerebellum ( p < 0.000001); LC—Hippocampus ( p < 0.0004); VTA/SNc—Cerebellum ( p < 0.000001); VTA/SNc—Putamen ( p < 0.0012); and VTA/SNc—Left MOG ( p < 0.0010).
The difference in infection rate was highly significant (p<0.00001), and the odds of a patient with colonisation having a subsequent infection was almost as high as 10:1 (OR (95%CI): 9.6 (2.7-34.0)).
In line with these observations, the 2 (task: judge number/mean size) x 2 (unattended magnitude: small/big) repeated measure ANOVA performed on PSEs estimates showed a highly significant interaction between task and magnitude of the unattended dimension (F(1,13) = 52.17, p<10 −5 ), with PSE estimates differing between small and large unattended magnitude only for the average size task (p<10 −5 ) but not for the numerosity task (p = 0.37).
The main factor Language was highly significant, F (1, 33) = 98.69, p < 0.00001, reflecting the overall better performance of Tashlhiyt than French participants.
The correlation between various stages of OSMF with SOD (per/ml) and MDA (nmol/dl) by Spearman's rank correlation method indicated a significant ( P = 0.0010) moderate inverse relationship between various grades of OSMF with SOD as Spearman R (r s ) was 0.5700 and a highly significant ( P = 0.00001) direct strong relationship between various grades of OSMF with MDA as Spearman R (r s ) was 0.6725 [ Table 4 ].
The results were highly significant (R = 0.96, p < 0.00001), indicating that the variations in codon usage are strongly correlated with the nucleotide content (i.e., GC content) of the genes.
The combined p ‐values obtained for the three hypotheses tested were highly significant ( p < 0.00001) in all cases. 4 DISCUSSION Differences in quantity and quality of the progeny are the most obvious consequences of mating systems and sexual polymorphism, but they are not the only ones.
These correlations, and all others discussed in this paper, were highly significant as assessed by permutation tests ( p < 1e‐5; Table S6 ).
The patient is assigned the high or low risk of relapse category if the score is ⩾2.41 or <2.41, respectively, with highly significant differences in RFS ( P <10 −5 ) and OS ( P <10 −5 ) between both groups.
In the SA27063 × A17 F 2 population a highly significant quantitative trait locus (QTL, LOD = 7.37; P < 0.00001) named r esistance to the n ecrotroph P homa m edicaginis one ( rnpm1 ) genetically mapped to the top arm of linkage group 4 (LG4). rnpm1 explained 33.6% of the phenotypic variance in the population's response to infection depicted on a 1–5 scale and was tightly linked to marker AW256637 .
One group was enriched 20–30-fold relative to the GST negative control, with highly significant P -values ( P < 1 × 10 −5 ).
This difference was highly significant (t = 10.35, p < 0.00001).
Considering all pairs of individuals, the regression slope b ± SE = 0.0097 ± 0.0018 was highly significant ( P < 0.00001).
This difference in means is highly significant ( P <0.00001).
To confirm that the reported effects are not isolated and support the structure of the comparisons shown, we ran Friedman tests as non‐parametric omnibus tests which yielded highly significant results (alpha band, p < 0.00001 , χ 2 = 115.93 , Kendall's W = 0.68 ; gamma band p < 0.00001 , χ 2 = 120.6 , Kendall's W = 0.7 ).
There was no heterogeneity (I 2 = 0%), and the results were highly significant ( Z = 5.03, P < 0.00001). 3.5.5.
Furthermore, a robust association between observed and predicted responses for TC degradation was evident from the highly significant regression model (p-value < 0.00001), high coefficient of determination (R2 = 0.9886), and well-adjusted R2 value (0.9780) 18 , 59 .
The frequencies of white choices in S1 and S2 showed a highly significant difference between sessions (χ 2 = 272.23, P <0.00001).
The first ranked ChIP-seq track found is the one against an overexpressed haemagglutinin (HA)-tagged MITF 21 , indicating a highly significant correlation between the E-box/MITF predictions and the ChIP-seq data (hypergeometric adjusted P -value<1.0e−05, Normalized Enrichment Score=31.2).
For example, witnessing violence toward siblings on the MACE showed a highly significant association with DES scores (β = 2.02, t = 4.75 p < 10 -5 ), whereas witnessing interparental violence did not (β = 0.60, t = 1.44, p = 0.15) and experiencing physical abuse had only a marginal association (β = 0.85, t = 1.83, p < 0.07).
The discriminant validity was demonstrated by highly significant differences ( p < 0.00001) between the treatment groups across multiple timepoints, with a strong effect size at three months.
A highly significant ( p ≤ 0.00001) reduction of E‐cadherin expression was observed in the order of HPV16+ < HPV18+ < HPV16+/18+ in both cell models.
Simple (paired t -) tests showed for the comparison of Fabrics 1 and 2 (the least and second least liked) a highly significant difference (t = -6.8, p < 10 -5 ), whereas Fabrics 3 and 4 (the second most and the most liked fabrics) were not significantly different ( t = -1.0, p > 0.1) and ratings for Fabrics 2 and 4 were just significantly different ( t = -2.3, p < 0.05).