“highly significant”

1 , Supplementary Figure S1 ).The modules were numbered in increasing order from 1 to 30 according to scores of the clustering algorithm 15 (Supplementary Table S1 ); 1 is assigned to the module with the highest score (most densely connected to each other).Next, we assessed whether genes of the clustered terms are significantly interconnected in physical interactions by comparing each of 30 modules with randomly generated networks having the same gene number of the corresponding module and confirmed the highly significant inter-connectivity of them 12 (Supplementary Figure S2 , S3 , p < 0.00001), meaning that their components are not randomly distributed in the interactome.

The difference was highly significant (p < 0.00001).

The production of potentially phased siRNAs alone is, however, not enough to class a locus as trans -acting so we concentrated on the 12 predicted highly significant loci with p values < 0.00001 and used the psRNATarget prediction tool [ 40 ] to identify potential targets for phased siRNAs (Table 2 , Additional File 6 ).

There was a highly significant correlation in the methylation status of the MGMT promoter region and MGMT protein expression ( p < 0.00001, Fisher exact test).

After adjusting for sex, age, and race/ethnicity in Model I, the negative association remained highly significant (β = −0.038, 95% CI: −0.045 to −0.031, p < 0.00001).

In contrast, a highly significant increase in midbody-flanking Sept2 ( p -value < 0.00001) and a corresponding decrease in Sept2 at the central midbody ( p -value < 0.00001) were detected relative to the Jurkat CypA+/+ cells ( Figure 1 E).

The positive relationship between φ and geographical distance was statistically highly significant (Mantel test, 100000 randomisations, r = 0.375, P = 0.00001), also when corrected for beetle phenotype (Partial Mantel test, 100000 randomisations, r = 0.379, P = 0.00001; see Materials and Methods for comments regarding the value of r of the Mantel test).

Heterogeneity analysis revealed highly significant heterogeneity ( p < 0.00001, I 2 = 88%), thus a random effects model was used for statistical analysis, and a subgroup analysis was performed according to the trial cycle.

The increments in luciferase activity produced by the addition of increasing amounts of human rMCP-1 to antigen stimulated cells were significant for the allele 1G (ANOVA F = 10.23, p = 0.005) and highly significant for the allele 2G (ANOVA F = 172.3, p <0.00001).

Furthermore, a robust association between observed and predicted responses for TC degradation was evident from the highly significant regression model (p-value < 0.00001), high coefficient of determination (R2 = 0.9886), and well-adjusted R2 value (0.9780) 18 , 59 .

Regarding the percent inhibition of paw edema, the main effects of the treatment and time factors were highly significant by the four solutions used ( P <0.00001), and their interaction was also significant ( P =0.006, 0.006, 0.0062, and 0.0058 for Manly’s approach, Edgington’s approach, Still and White’s permutation of residuals and ter Braak’ methods, respectively).

These data demonstrate a high degree of gene expression dysregulation in the peripheral blood of patients with FA with a highly significant ( P < .00001) skewing in favor of upregulated genes.

As demonstrated by the high odds ratio (log 2 (OR)>6) between all the data sets, we showed that there was a highly significant overlap in RI (Fisher’s exact adjusted p<1e−05, Figure 1—figure supplement 2a ).

In models predicting RT, there was a moderately sized and highly significant main effect of congruency in which participants were slower on incongruent as compared to congruent trials ( η 2 = .177, p < .00001) and a small but significant main effect of valence in which participants were slightly slower when angry faces were the task-irrelevant distractor as compared to happy faces, but the effect size was miniscule ( η 2 = .003, p < .00001).

The sensitivity analyses comparing mean DFI difference in IVF patients according to the 95% CI of the mean difference in controls was also highly significant (P <0.00001).

There was a strong relationship with sleep disturbance as indicated by highly significant correlations with all four SQS subscales (all p < 0.00001) but not with hours of sleep.

This study showed that duration of analgesia was 37% higher for Bupivacaine which lasted for up to an average period of 7.3 hrs which was highly significant (p=0.00001*).

The difference between the MS and the control group regarding the frequency of a positive MRZ, MRZB or MRZBU reaction, as defined by a bi- or trispecific response, was highly significant ( p < 0.00001, Mann–Whitney U test, irrespective of whether the single steroid-treated control patient was included or not).

Pre-saturation of EGFR on A431 cells with an excess of both non-labeled ZEGFR:2377 and cetuximab caused a highly significant (P<1×10 −5 ) reduction of 89 Zr-DFO-Z EGFR:2377 binding to the cells.

The pooled HR remained highly significant (HR = 0.56, 95% CI 0.45–0.70; P < 0.00001) ( Supplementary Figure 1A ). 3.3.2.

The association of these macrophages with Hodgkin lymphoma is highly significant compared to biopsies for nonneoplastic conditions ( P < 10 −5 ), and the other malignancies examined ( Figure 3 ).

They found a highly significant difference in mean %EWL of 17.98% (95%CI: 8.37-27.58, P < 0.00001) in the balloon group in comparison to the sham/life-style modification group.

Predictive Value of the First Injection on Long-Term Outcome There was a highly significant (r = 0.855, p < 0.00001) correlation between the outcome 30 days after the first injection and the outcome after one year of continuous 3-monthly injection therapy for the pRoMs ( Figure 3 A).

A posterior-dominant pattern of ‘neural slowing’ was observed, with increased theta band power in PD that was highly significant ( p < 0.00001), as well as a spatially similar concomitant decrease in gamma-band activity ( p < 0.00001)—in other words, an increase in low frequency activity and a decrease in high frequency activity.

Correlation analysis between the co-expression module and traits was carried out, and two highly significant trait-related modules (|cor| > 0.75, p -value < 1 × 10 −5 ) were identified.