“highly significant”

Nine out of these thirteen PRGs (69%) exhibited production overshoot in MCF10A cells indicating highly significant overlap ( P <4.0E−06, hypergeometric test).

This enrichment for Nfkb1 interacting genes is highly significant ( P = 4e-6).

Likewise, COX2 dimer (the 2nd largest protein in our set, with N = 1,104) exhibited a highly significant overlap ( P = 4.008 × 10 −6 ) with m = 18; and PA (the 4th largest; N = 763, m = 10) also yielded a P -value of the order of 10 −6 .

The difference in average motif spacing calculated within the prediction groups, compared between completely rigid motif complexes (single-spacing) and flexible complexes (more than one spacing) was found highly significant ( p = 4.07e-06, Mann–Whitney U test).

Out of the ten possible three-way interactions, two produced highly significant results: properly aligned BRE-Inr-MTE combinations are nearly four times as likely in the real dataset than in the randomized data (p = 4.1 × 10 -6 ), and the TATA-Inr-MTE combination is about 50% more likely in the real data versus the random data, which is also significant (p = 0.0042).

In these 6 families, we found highly significant associations between SNVs in the Disks Large-associated Protein 1 (DLGAP1) gene and grip strength (lead SNV: β= -0.75kg ± 0.15, p-value= 4.3*10-6).

The correlation between these two variables is highly significant (Spearman ρ = 0.565, p = 4.3 × 10 −6 ), and even stronger for the peak of facilitation at 3 ms ( ρ = 0.634, p = 1.5 × 10 −7 ).

A Paired T-test showed a highly significant difference in time-to-complete retrofitting tasks between the proposed framework and CloudCompare, T(15) = 2.78, p = 4.35 × 10 − 6 .

Correlation Analysis There were highly significant positive correlations between antigliadin IgG antibodies and claudin-1 (r=0.554, p=4.39*10 −6 ), and between claudin-1 and i-FABP (r=0.687, p=1.38*10 −9 ).

Within the HoA+, Pf PR was a highly significant predictor of Pv PR Fy+ (p = 4.4x10 -6 ) up to 15% Pf PR, after which increases in Pf PR did not result in further predicted increases in Pv PR Fy+ ; in contrast, Pv PR Fy+ within the HoA+ was a significant linear predictor of Pf PR at all levels of endemicity.

This is exemplified by the highly significant difference in PPA activity in no-blink vs. blink trials (t(23) = 5.97; p = 4.4*10-6), listed below.

Finally, the KEGG database showed the “mitigation of Neutrophil extracellular trap pathways” as a highly significant ( P = 4.5 × 10 -6 ), suggesting that ASCs modulate the inflammatory cascade via neutrophil activity.

Looking first at the conservative simple Reference Range Plus method, the analysis found a highly significant genotype effect as a high proportion of the rats were classified as low ( Table 2 ) (male dataset, p value = 4.75e-6 with a 43% change in classification and female dataset p value = 4.64e-3 with a 26% change in classification).

Strikingly, 8 of the 9 known CHD genes in the module were within the hub, representing a highly significant enrichment ( P =4.787×10 −6 ).

The lack of RCCGGY motifs within the regions surrounding σ E- regulating genes as well as vchM itself was highly significant (p-value ~4.8e-6).

For the different-strand overlaps, the majority of transitions (~60%) were due to 3' end change; the chi-square goodness-of-fit test for equal proportions of 5' and 3' changes is highly significant (χ 2 = 20.93, p-value = 4.8e-6).

We were not able to obtain similar predictive power using the DNAm age predictor proposed by Horvath, which has a highly significant but much weaker correlation with GA (r = 0.14, p = 4.89 × 10 −6 ; Additional file 1 : Figure S5).

The perfect association between copy number of the duplicated sequence and the fast/slow greying phenotype including both Connemara ponies from Sweden and Thoroughbreds from Japan is highly significant (Fisher’s exact test; P = 4.9 × 10 -6 ) (Fig. 3c , Supplementary Fig. 4a , Supplementary Table 2 ).

The likelihood ratio test suggested a highly significant linkage disequilibrium between D6S446 and D6S1590 (p < 5 ×10 -6 ).

Saturation of PSMA with a large excess of unlabeled compound causes a highly significant (p< 5 x 10 -6 ) reduction of binding of each labeled compound to cells, which demonstrates the saturable character of their binding ( Figure 3 ). 3.3.

In addition, highly significant departures from race-specific Hardy-Weinberg equilibrium (P-value < 5e-6) are excluded from the data.

The breed ages were then plotted against the proportion of deleterious SNPs ( δ ) and a highly significant negative correlation was observed (Pearson r = − 0.86, P = 0.000005) (Fig. 2 ).

These correlations were still highly significant within the AM group (all 3 r ’s ≥ 0.55, all 3 P -values ≤ 5.0 × 10 −6 ).

Region of interest (ROI) analysis confirmed a highly significant decrease in PE values in Met 158 -, compared to Val 158 , homozygotes (F 1,53 = 34.0; p < 0.000005; Fig. 2 , which was unaffected by the inclusion or exclusion of age as a covariate).

At age 7, asthma control test scores showed a highly significant difference between children with and without asthma ( p = 5.0 × 10 −6 ), as expected, but no significant difference (Fisher's Exact Test, p > .05) in spirometry (FEV%) or medication with leukotriene receptor antagonist (LTRA) or inhaled corticosteroids (ICS) the 24 h preceding any of the visits was observed.