“highly significant”

Analysing this group against the remaining groups combined was highly significant ( P =0.000003) ( Figure 4d ) and was an independent prognostic factor ( P =0.0003, HR=0.1, 95% CI=0.0–0.4) ( Table 2 ).

p21 prevalence differed significantly between most nevus and melanoma categories, and the overall trend with progression was highly significant ( r = 0.528, P = 3 × 10 −6 ; Table 1 ).

Conversely, the recA generalized linear model showed little difference to the null model ( p -value = 0.93), whereas that of pstS showed a highly significant difference ( p -value = 3.08×10 −6 ) from the null model ( Figure 4 ).

The correlation between phenotypic and carbapenemase genes detection was highly significant for K. pneumonia, E. coli, P. aerugnosa and A. baumannii ( P = 0.0000031; P = 0.00079; P = 0.015; P = 0.02, respectively) while for ESBL genes correlation was only significant for P. aerugnosa ( P = 0.038) Table 3 .

When correlating with pathological biomarkers, the SI showed strong correlations with all the measurements ( P ≤ 3.2e−6), with the weakest correlation observed for diffuse plaque, which was still highly significant ( P = 3.2e−6) ( Fig. 2C ).

This overlap of DMRs between replicated experiments is highly significant ( P -value = 3.3 × 10 −6 ).

There were about 146/275 (53%) of the CPC-1 up- and downregulated genes under amino acid starvation exhibiting rhythmicity, indicating a highly significant enrichment of CPC-1 regulated genes as clock-controlled genes (p = 3.341905e−06, hypergeometric distribution test).

Using Fisher's exact test, the association between claudin-4 and CA125 positivity was shown to be highly significant (P = 3.4 × 10 -6 ), confirming the lack of independence between these two markers.

The overall joint test of the SSTR5 haplotypes on presence of acromegaly (comparing acromegaly patients and control II group) was highly significant ( P =3.4×10 −6 ).

The correlation remained highly significant in most cohorts of each cancer type ( R = 0.73, P = 3.4 e‐06) (Fig. 2E and Fig.

Following variable selection including only those significantly contributing to the class difference the multivariate difference between Groups was highly significant (p = 3.5 ∗ 10 − 6 ).

Mediation analysis evidenced a highly significant direct effect of total HA experience on LE (with more than 1 point increase in EEAS per log(years in HA experience) (1.051 (SE = 0.227), z = 4.6, p = 3.5 × 10 −6 ), a significant but weaker indirect effect mediated by better ear hearing threshold (0.216, (SE = 0.072), z = 3, p = .003 ) that represented only 17% of the effect seen (total effect estimate: (1.267 (SE = 0.22), z = 5.73, p = 10 −8 ).

The correlation between RDW and AML risk remained highly significant when controls without ARCH-PD were excluded from the analysis (P=3.5 x 10 -06 , Wald test with Bonferroni multiple testing correction, Extended Data Fig. 5b ).

In contrast, aggregating the five previously published twin register-based studies, which comprised 492 twin pairs, revealed proband wise concordance rates of 19.5% for MZ twins and 2.3% for DZ twins, a highly significant difference (OR = 6.71, 95% CI = 2.21–20.35; p = 3.6 × 10 −6 , Fisher’s exact test).

However, tests of homogeneity of multivariate dispersion revealed highly significant differences in within-group variability (beta dispersion: F (2,41) = 17.25, p = 3.68 × 10 −6 ; permutation test: p = 0.001).

ANOVA was highly significant ( p = 3.71e−06).

Analysis with the functional annotation clustering tool provided by DAVID [ 52 ] revealed one highly significant functional group in this cluster (p-value = 3.73 × 10-6).

While differences between normal aging and AMD were not significant, the percentage of CD34 negative capillaries in old eyes, compared to young eyes, was highly significant (p = 3.8×10 −6 ).

However, we now found a highly significant difference between normal breast vs breast tumour ( P =3.8E−6) ( Figure 1B ).

Quantification of IL-6 mRNA with qRT–PCR revealed a highly significant increase in the mean IL-6 / ABL ratio in GBM (33.3%) as compared with non-GBM (1.5%; Kruskal–Wallis test, P =3.8 × 10 −6 ).

Other highly significant genes included SLC14A2 on chromosome 18 (P=3.80×10 −6 , FDR =0.0089) and CHD7 on chromosome 8 (P=5.37×10 −5 , FDR =0.0359).

The Spearman correlation between the median relative r parameter from chromosome 1–22 and the relative gene density was equal to –0.81 (95% confidence interval: [-0.92, –0.60]), indicating a highly significant inverse relationship ( P = 3.9e-06).

ANOVA across species was highly significant ( F (3,16.70) = 22.70), P = 3.97 × 10−6), post hoc tests (BH-adjusted) confirmed E. turneriana as significantly lower ( P < 0.01).

A post-hoc Games–Howell test (Tukey corrected p values), was used to compare each mutant genotype to the wt since this test is compatible with the highly significant inequality of variances (Levene’s test, p = 3.98 × 10 −6 ).

This enrichment for Nfkb1 interacting genes is highly significant ( P = 4e-6).