“highly significant”

The majority of these (78%) also contain STAT1 peaks, a highly significant overrepresentation (p = 1.97e-6; Table S2 B).

Moreover, the enrichment in these deficiencies observed in MIS-C patients relative to the individuals included in gnomAD was highly significant ( P = 2 × 10 −6 ).

This difference between normal and tumor tissue was highly significant (p-value = 2*10 −6 ).

The difference in differentially expressed mature miRNAs in the 22q11.2 del region that showed nominally significant differences in expression compared with mature miRNAs generated from the remainder of miRNA genes on chromosome 22 is highly significant (Fisher exact test, p = 2E-06).

The single exception is Prs3-F[1,2]:Fpr1-F[3], which displayed a small but highly significant fitness advantage (fitness=0.04, P value <2 × 10 −6 , Bonferroni corrected one-sided Student's t -test) that is perhaps due to an adaptive mutation that occurred in the parental PCA strain before barcoding.

The determined Spearman’s correlation was 0.87 and highly significant ( P = 2 × 10 −6 ), as was the Pearson’s correlation (0.85; P = 4 × 10 −6 ).

The corresponding rm-ANOVA (3 face conditions×14 ROIs) showed highly significant effects of Face condition (F(2,18) = 30.4, p<0.000002, H-F epsilon = 0.997, p<0.000002), and ROI (F(13,117) = 4.44, H-F epsilon = 0.26, p<0.008), and a significant interaction between these two factors (F(26,234) = 2, p<0.005, H-F epsilon = 0.5, p<0.03).

For the VL muscle, a strong and significant correlation was already evident during R 1 ( r = 0.71, p = 0.014), and this relationship intensified to a very strong, highly significant correlation during R 2 ( r = 0.96, p = 0.000002), as depicted in Figure 5 . 4.

In this model, the coefficient for WAS presence was positive and highly significant, as expected (coefficient = 3.24, p = 2 × 10 −6 ), indicating that it was related to an increase in SRB.

The analysis revealed a significant effect of sample type ( F = 4.70, p = 0.020) and a highly significant effect of treatment time ( F = 38.65, p = 2.00 × 10 −6 ), indicating that both hydrogel composition and healing time significantly influenced wound recovery.

Differences between the data from this study and published data are highly significant, with p = 2 . × 10 −6 nd p = 7 × 10 −6 , correspondingly.

Pathway enrichment analysis using MetaCore (pathway analysis software from GeneGo) resulted in a highly significant enrichment of genes encoding proteins involved in cytoskeletal remodeling (P = 2 × 10 −6 ), adhesion (P = 4 × 10 −6 ), metaphase checkpoint (P = 7 × 10 −6 ), and cell cycle regulation (P = 7 × 10 −5 ) pathways.

A χ 2 test comparing the 2 treatments (without collection date as a factor) indicates that the difference in cure rate of 80.8% vs 100% is highly significant, χ 2 = 22.6, n = 222, d.f. = 1., p = 2e–6.

The addition of IL-6 and IL-8 to a model of mortality prediction composed of clinical variables was highly significant (LR P = 2 × 10 −6 and 1.5 × 10 −5 , respectively) ( Supplementary Table 4 ).

The differences in gene expression between the immune clusters were highly significant for all 10 cell populations (all p < 2e-06) (Supplemental Figure S3a).

Although the sample size was small, this association was highly significant (p=0.000002), warranting further study of variables and associations.

For example, the mean temperature differences between the phantoms with and without magnetic nanoparticles were significant ( p < 0.02) for 10.3 W of acoustic power and highly significant for 5.8 W and 2.7 W ( p < 0.000002 and p < 0.0000005, respectively).

The comparison between groups A and B, both located in introns of genes expressed in placenta, shows that group A displays highly significant lower methylation than group B ( P = 2e −06 ).

Analysis of data from field Summer 2018 and greenhouse Spring 2019 showed very highly significant correlations (all P values <2.0E−06) between the two conditions for all four traits (cuticle thickness—r = 0.99; intercalation depth r = 0.96; diameter of lipid droplets r = 0.84; epidermal cell height r = 0.86) ( Supplementary Table 6 ).

We found a highly significant effect of compression ( P = 2e-6) with an estimated ABpr/ABpl ratio of 0.99 for the uncompressed embryos ( Supplementary Fig.

However, it was highly significant on the individual level with greater power (B = 5.4, p = 2 × 10 –6 ), suggesting that in Eastern Hungary the trend of respondents in larger settlements having later chronotypes is amplified.

In a meta‐analysis including 13 independent samples (total N = 1402), the EII demonstrated validity in assessing degree of personality disturbance, its overall weighted effect size with other measures of psychiatric severity being r = 0.29 and highly significant ( p = 0.000002) (Diener et al., 2011 ).

A systems biology weighted gene co-expression network analysis of 16 human NASH, 10 NAFLD, and 19 normal liver samples identified a highly significant module ( p < 2 × 10 −6 ) associated with RNA processing ( 86 ).

The functional annotation analysis of Ang II–dependent transcriptome using DAVID database 11 revealed highly significant enrichment for genes associated with blood vessel development ( P < 2 × 10 −6 ), angiogenesis ( P < 7.9 × 10 −6 ), positive regulation of proliferation ( P < 0.002), and several associated signaling pathways, including cytokine–cytokine receptor interactions ( P < 0.0076), transforming growth factor-beta pathway ( P < 0.01), notch signaling ( P < 0.02), and protein kinase activity ( P < 0.025) (Fig. 1 ).

In all tissues and platforms, we observed highly significant but small positive correlation between differences in gene expression as measured by p -values and CNV size (all p < 2 × 10 −6 and all rho < 0.22).