“highly significant”

Alternative alleles for another family member, Sb02g029725 ( SbFT6 ), mapping near another flowering QTL, also showed highly significant association with photoperiod response index ( P = 1.53×10 − 6 ).

Of note, half of the 11-bp inverted site overlaps with a highly significant direct repeat BfmR motif ( P -value = 1.55 × 10 –6 ) that is located between the predicted −35 and −10 elements (Fig. 7D , dotted box).

The main, highly significant finding of our study was that lactate (Discovery group: p<1.6x10 -6 , q = 0.00; Test group: p = 0.003; q = 0.047) and pyruvate (Discovery group: p = 0.017, q = 0.27; Test group: p = 0.010, q = 0.10), two products of anaerobic respiration in glycolysis, were significantly elevated in the PTSD-positive subjects compared to the PTSD negative subjects.

A t- test comparing these two groups (SOA < 300 and SOA > 300) is highly significant ( t = −4.80, p < 1.6 × 10 −6 , CI: 43 to 103 ms).

Univariate analyses by pair wise comparison of EFS methylation with the variables listed in table 1 revealed a highly significant correlation of the EFS methylation with the chromosome 3 status (p = 1.6 × 10 -6 ) and cell type (p = 0.006).

Highly significant enrichment was uniquely found within the first quartile of ranked genes, including transcription regulation (p < 1.62 × 10 -6 ) and regulation of cellular metabolic processes (p < 4.3 × 10 -4 ).

Using data from an independent sample that identified dexamethasone-responsive CpGs on a genome-wide level ( Provençal et al., 2020 ), we observed a highly significant enrichment of dexamethasone-responsive CpGs within the PedBE clock (Fisher's Exact: p = 1.65*10–6, Odds Ratio = 4.36).

In the RIF-M subtype, the dysregulated genes were primarily linked associated with LH + days and smoking status: TM7SF2 exhibited the strongest negative correlation with LH + days ( p = 2.65 × 10 − 5 , R = -0.35), and NFIA demonstrated a highly significant negative correlation with smoking status ( p = 1.69 × 10 − 6 , R = -0.18) (Fig. 4 D).

When applying this approach to ISO and SHORT birds, we find an offset of βiso=0.19 and a nonzero fixed effect of tutoring βshort=0.08 that was highly significant ((βshort≠0, p=1.7*10 -6 , 32 observations, 2 fixed effect coefficients, 8 random effect coefficients).

Compared with Bulgarian control CNVs, we found a highly significant excess of PSD genes within case de novos ( P =1.72 × 10 −6 ; Table 2 ).

For CUI WCE dataset, the performance results for ELM classifier were highly significant such as p = 1.74 × 10 ( − 6 ) for t -test.

The difference between the genetic diversity for the data points from the two categories is highly significant (Wilcoxon signed-rank test, p = 1.77 × 10 −6 ).

Among the 41 downregulated transcripts in trophozoites in HbAS children, the most highly significant was that encoding a putative acid phosphatase (PF3D7_1430300; log 2 fold change = −2.37; adjusted P = 1.77 × 10 −6 ).

These learning-related reductions in activity were also statistically significant in our predefined ROIs in premotor (dorsal premotor cortex – PMd) and parietal cortices (anterior superior parietal lobule – SPLa) ( Figure 3b ): In a 3 (week) x 2 (sequence type) ANOVA on observed activation both main effects and interaction were highly significant in PMd (week: F (2,50) =17.47, p=1.77e −6 ; sequence type: F (1,25) =11.86, p=2.03e −3 ; interaction: F (2,50) =13.22, p=2.46e −5 ) as well as in SPLa (week: F (2,50) =19.14, p=6.73e-7; sequence type: F (1,25) =19.36, p=1.77e −4 ; interaction: F (2,50) =21.59, p=1.74e −7 ).

Results Behavioural data We observed a highly significant main effect of endogenous effort modulation on RTs for correct trials (EXR-RLX: F (1,44) = 30.30, p = 1.79e-06), in addition to the expected main effect of stimulus type (incongr-congr: F (1,44) = 1437.20, p = 3.07e-35).

On average, DESTINI improves cluster coverage by 0.04, which is very small, but statistically highly significant (Wilcoxon pair test P-value = 1.8 × 10 −6 ).

The comparison of circulating STC1 in the 2 groups adjusted for delivery mode, smoking status, maternal age, and prepregnancy BMI resulted in highly significant difference (linear regression, β = 500.8 pg/mL; P = 1.8 × 10 −6 ) ( Figure 1 A).

Cluster 3 had multiple highly significant correlations (203, with an absolute value of rho ≥ 0.5 and P < 1.8 × 10 −6 ) including a group of proline-related metabolites (4-hydroxyproline, prolyl-hydroxyproline, and 4-hydroxyglutamate).

A highly significant correlation was observed between the change in NI score and the measured change in exon-inclusion level ( r = 0.661, p = 1.9 × 10 −6 ), providing support for the ability of NI scoring to predict changes in splicing regulatory activity resulting from point mutations.

In the dominant model, carriers of the rs5743899 G allele or rs3750920 T allele were compared with homozygous individuals for the A or C allele respectively and the difference were highly significant (P = 1.9x10 -6 OR, 1.8 [95% CI 1.4–2.2] and (p = 5.4x10 -6 ; OR, 1.7 [95% CI 1.4–2.2]).

Importantly, the interaction between clinical outcome and time was also highly significant (F = 8.48, p = 1.9 × 10−6), indicating distinct temporal diversity trajectories between responders and non-responders ( Figures 2B and C ).

12.4% of the genes with one or more DMRs from S1 to S2 resulted in corresponding transcriptional alterations, which represented a highly significant overlap (Fisher’s exact P = 1.9 × 10 − 6 ).

Results We found a highly significant statistical association between circadian pathway genetic variation and the risk of breast (pathway P value = 1.9 × 10 –6 ; top gene RORA, gene P value = 0.0003), prostate (pathway P value = 4.1 × 10 –6 ; top gene ARNTL, gene P value = 0.0002) and lung cancer (pathway P value = 6.9 × 10 –7 ; top gene RORA, gene P value = 2.0 × 10 –6 ), as well as all their subgroups.

As a further control, we compared the frequency of homopolymer frameshift mutations in these genes to the proportion of all exonic length 8 C:G or A:T homopolymers mutated across the cohort and found highly significant enrichment of homopolymer frameshift mutations in the MSH6 C8 homopolymer (37.3% versus 23.4%, P = 1.9 × 10 −6 ) and the MSH3 A8 homopolymer (67.3% versus 9.9%; P < 2.2 × 10 −16 ).

Ubiquitination and proteasome Surprisingly, we found that a highly significant proportion of genes of the non-cycle oocytes/hESC signature was involved in the protein ubiquitination and proteasome canonical pathway ( P -value ≤ 1.93E-06, using Ingenuity software) (Figure 3A ).