“highly significant”

Calcium ion binding related loci were sequestered out of modules at a highly significant level (Z-score = −18.1, two-tailed p-value<1e-6), which indicates that unlike more coherently regulated systems, calcium ion binding does not co-express strongly with other genes.

Kolmogorov-Smirnov test showed this difference to be highly significant (p < 10 −6 ).

The difference between means of traffic exposure groups was highly significant (Wilcoxon test, p < 0.000001).

showed a highly significant correlation between final VA and the presence of RD (p <10 -6 ) which makes retinal detachment one of the main limiting factors for a favorable visual outcome ( 6 ).

First, the main effect of stimulus disparity was highly significant (F(2.12, 29.68) = 27.99, p<10 −6 , r = 0.667, S1 Table ) in rANOVA.

Overall, TIN‐signature genes show a highly significant ( P < 10 −6 ) enrichment for proximal SEs at all distance ranges measured (Fig. 5 C).

There was a highly significant time effect, group effect and interaction between time and group ( p < 10 –6 ).

Upon initial analysis, the storage process demonstrated a highly significant effect (Hotelling multivariate p-value = 1 × 10 −6 ).

A total of 151 genes were regulated by hypoxia in both datasets (Figure 1D ), and a permutation test revealed such an overlap between the two datasets was highly significant ( P < 1 × 10 −6 ; Supplementary Figure S1B ).

However, for intergroup comparison, the difference between the two modes was found to be highly significant in both sedated and awake states if we considered inspiratory hold in PAV+ as PMI ( P = 0.000001 for both states).

These clusters are robust to changes in network parameters and are highly significant (p-value < 1 x 10 -6 , permutation tests).

The prevalence varied between 18.2 and 50.7 %, depending on locality, and this variation proved to be highly significant (χ 2 = 59.599; P < 0.000001) (Table 1 , Fig. 1 ), suggesting a focal occurrence of borreliosis.

The analysis of discriminance revealed a highly significant discrimination between diabetic patients and controls (Wilks lambda: 0.27; P < 0.000001).

Such a difference is highly significant ( p < 0.000001, Figure 5 a) and corresponds to a significant difference ( p = 0.02656) between the corresponding E distributions.

In all cases, the post-hoc contrasts were highly significant (p-value < 1 × 10 −6 ).

It is important that Thioalkalivibrio , Pediococcus , and Faecalibaculum showed highly significant disparities (FDR-adjusted p < 1.0 × 10 −6 ).

Corresponding studies with 89 Zr-DFO-ZEGFR:2377 resulted in 17.7 ± 0.3% (A431) and 23.8 ± 0.2% (MDA468) cell-associated radioactivity. Pretreatment of A431 and MDA468 cells with EGFR specific antibody cetuximab led to a highly significant (<0.3% of total activity; P < 1 × 10 –6 ) reduction of binding of 89 Zr-labeled affibody bioconjugates indicating highly specific targeting properties ( Figure 3 A).

SNP with call rates < 0.98, minor allele frequencies (MAF) < 0.03 and highly significant deviations ( P < 10 -6 ) from Hardy-Weinberg Equilibrium (HWE) were also excluded.

Similarly, the marital status distribution (35 single individuals out of 40 cases) showed a highly significant deviation from the expected proportion ( p = 0.000001), suggesting that single individuals are at notably higher risk.

An umbrella review of systematic reviews and meta-analyses evaluating the association between environmental risk factors and AD showed that late-life depression and type 2 diabetes mellitus are the most significant; cancer, depression at any age, and physical activity are also highly significant ( p < 10 −6 ) in AD development.

The observed reductions with the extracts were highly significant (significance p < 1*10 –6 ).

Although this pattern is consistent with the expectation that more functionally important genes (i.e., those that are more highly expressed) will exhibit reduced rates of introgression, these effects explained a negligible proportion of the variance (R 2 < 0.01 for both Asian and European data sets), and the relationship between mitochondrial targeting and introgression remained highly significant after controlling for this measure of transcript abundance ( P < 1 × 10 −6 in both Asian and European data sets).

ANOVA with the main factor Age-Group (adults, children) and repeated measures factor Velocity (3 conditions) revealed a highly significant effect of Velocity on gamma power (F (2,122) = 172.8, ε = 0.87, p < 1e −6 ; η 2 = 0.74), but no effect for the Age-Group or the Age-Group*Velocity interaction (p’s > 0.6).

When all tumor samples were evaluated together the correlation of GZMH, ABL1, IL-7, LY9, IL-12, SCAMP3, and CD244 were highly significant ( p < 1 × 10 −6 ).

As shown in Figure 3 , while reduction in binding after treatment with unlabeled DARPin 9_29 was highly significant ( p < 0.000001), there was neither significant reduction in binding after receptor saturation using trastuzumab ( p > 0.05) nor any reduction in binding after treatment of SKOV-3 cells with cetuximab or bevacizumab.