“highly significant”

Most strikingly, an independent analysis identified a highly significant overlap in the differentially expressed set of genes: the correlation between the expression ratios in the two studies was 0.57, with a corresponding of P = 1.27×10 −7 .

The association at rs2735591 is highly significant in the combined validation samples ( P = 1.27 × 10 −7 , OR = 1.27), even after correction for all the 4363 SNPs tested in the current study ( P corrected = 5.54 × 10 −4 ) and surpassed the genome-wide significance threshold ( P = 1.03 × 10 −9 , OR = 1.24) in the combined GWAS and two independent validation series, consisting of a total of 3148 cases and 7843 controls (Table 2 ).

Importantly, comparing genes differentially expressed in NPM1c/FLT3 -ITD mutated human AML 19 with our differentially expressed genes between DM and WT HSPC, we could demonstrate a highly significant overlap with 27% up- (119/441, p =1.28e-07) and 15% (74/503, p =1.27e-07) of downregulated human genes also evident in our dataset Figure 1h ).

MDV infection induced a highly significant increase in H3K4me3 enrichment in the promoter region of MX1 in both lines (line 6 3 : p = 1.28x10 -7 , line 7 2 : p = 4.26x10 -9 ; Figure 2 A).

For instance, the MEblack module showed a highly significant negative correlation with the pelargonidin-related trait (r = −0.972, p = 1.29e−7), suggesting that genes within this module may be negatively associated with pelargonidin accumulation.

The nonsense variant showed a highly significant association with white spotting ( P = 1.3 × 10 −7 ; Table 1 ).

Results and Discussion Results of the cross-correlation analysis for Tenna show highly significant correlation of input water (rain + irrigation) and the soil moisture at 30 cm at time (day) lag 1 ( r = 0.55845; p = 1.31 × 10 −7 ).

This difference was found to be highly significant (ANOVA P = 1.31 x 10 −7 , α = 0.05).

We observed a moderate but highly significant positive correlation between rankings (Kendall’s rank correlation tau = 0.31, P value = 1.32e−07 for GRADE and SE 95% PI rank).

Additionally, we also tested for the confounding of age, gender and region altogether and found that the P-value remain highly significant (adjusted P = 1.32×10 −7 ; odds ratio = 328.87).

The effect on c-Kit was highly significant (differential log2FC = 3.95, p -value = 0.000000136).

However, it is striking that among the Beijing lines there is a wide variability in PI content ( Figure 2A ), and inter-line variability is highly significant ( P -value = 1.37×10 −7 .

As expected for a set of chromatin-associated proteins, we observed highly significant enrichments for the clusters “Chromatin organization” (FDR-corrected P values ≤1.374e-7) and “Regulation of transcription” (FDR-corrected P values ≤1.433e-6).

A total of 2217 ♂♂ were caught in the traps within nine days, with only 12 ♂♂ found in the empty control traps, showing a highly significant difference (Wilcoxon rank sum test with continuity correction: W = 8.5, p = 1.388 x 10 -7 , Fig. 4 , 2006, left).

This analysis was subsequently performed by comparing GSD CAD cases to CAD controls of GSD and five LRCAD breeds, and resulted in the same top SNP 27: 19,086,778 as in the GSD association analysis with a highly significant p -value (p = 1.4 × 10 −7 ).

This difference was highly significant (Wilcoxon test, p = 1.4×10 −7 ).

The difference between dengue fever and dengue hemorrhagic fever was highly significant overall (OR = 5.84; P = 1.4 × 10 −7 ).

4 ) revealed a highly significant separation of the three survival curves for locoregional recurrence-free survival ( P = 1.42 × 10 − 7 ).

As shown by Figure S1 , most of the PTVs have high PHRED scores of over 20, and there is a highly significant positive correlation between PHRED score and the number of votes for being predicted as damaging using dbNSFP ( p < 1.45e‐07).

Sign tests for the results of the three studies with N >50 were always highly significant (concordance rates=69–80%, P =1.5 × 10 − 7 or smaller).

This highly significant skew toward more nonsynonymous mutations (chi-square test, P = 1.5 × 10 −7 ) strongly supports selection-driven parallel evolution.

The trait pair exhibited a strong and highly significant genetic correlation ( r g = 0.8125, SE = 0.1547, P = 1.50 × 10 –7 ), empirically justifying their integration into a multivariate framework.

Accordingly, the Side × Effector interaction remained highly significant ( P = 1.55 × 10 −7 ), confirming that the nondominant disadvantage persisted after statistically controlling for execution time.

More broadly, mRNAs putatively mis-spliced in p62 −/− brains included a highly significant proportion of mRNAs (97 of 862, p = 1.57 × 10 −7 ) that bound to FUS and were mis-spliced in FUS-deficient brains 41 (Fig. 5m , Supplementary Fig. 5p ).

This showed that the average G-C3 for singleton genes was 0.416, while the value for UCO arrays was 0.676; this was a highly significant elevation in third position G-C content (df = 10, t = -11.89, p = 1.57 e-07 ).