“highly significant”

The test revealed a highly significant reduction in prediction error with the hybrid approach ( p = 5.97 × 10−8).

This is supported by a highly significant (p = 6 × 10 −8 ) tendency for operon-encoded subunits to be lower in abundance than subunits from complexes encoded by different transcriptional units ( Figure 1 C).

Despite the small sample size, the burden of association between BMPR2 and PAH was highly significant ( p = 6.0 × 10 −8 ) compared to the genome-wide significance threshold ( p < 2.4 × 10 −6 ) after Bonferroni correction for approximately 21,000 genes (Fig. 2 ).

In line with the elevated S-ASM activities in patients, we have found strong and highly significant correlations of S-ASM with these liver enzyme activities (Rho > 0.37 and p < 6 × 10 −8 for all three enzymes, Table 2 , Figure 3 ).

We found a highly significant increase in the deposition of collagen surrounding the ducts in the PAPP‐A transgenic females compared to the non‐transgenic females ( P = 6.013 × 10 −8 ) (Fig 2 F).

In this cancer, a highly significant positive correlation was seen between the amount of nuclear FL BARD1 and nuclear p50 protein ( P = 6.14 × 10 −8 , Fisher’s exact test).

Here, the difference was highly significant for pyramidal neurons (Fig. 2 c; p = 6.3 × 10 − 8 ).

Also, the meta-analysis on these cohorts was highly significant ( P = 6.35 × 10 −8 for rs7021880).

When the NAFLD phenotype was defined by ALT-threshold + dyslipidemia (ALT2DL, S6c Table in S1 File ), the association was highly significant in participants of EU ancestry (OR 1.05, P = 6.5x10 -8 ) as well as in the trans-ethnic meta-analysis (OR 1.05, P = 7 x 6.5x10 -9 ).

These filters resulted in a 10-fold reduction of the amount of data (from 32439 to 3243 CRUFTS or 6534 to 1593 non-overlapping regions) and increased the enrichment of known ncRNAs 2.17 fold, which is highly significant (p = 6.6e-8) (see Table 1 ).

These population differences are highly significant (Fisher’s exact test, p = 6.7e−8), and show that wS2 represents less low-level whisker kinematic information, or as we call it from now on, fine features.

A one‐way ANOVA revealed a highly significant difference in mean gall counts between genotypic classes ( F = 38.36, p = 6.73 × 10 −8 , R 2 = 0.78).

Ferroptosis Pathway Interestingly, KEGG pathway enrichment analysis demonstrated that ferroptosis (ID: hsa04216) ( Figure 4 A) was enriched at a highly significant level ( p -value = 6.79 × 10 −8 versus control) for the dual treatment (PRO plus CAP) than in other single treatments ( p -value = 0.05; PRO, p -value = 3.34 × 10 −6 for CAP versus control), which confirmed the synergistic interaction of the dual treatment that was obtained from the cytotoxicity study.

The average codon volatility for the H class genes was 0.7609 + 0.001 while the S class had an average volatility of 0.7746 + 0.002 (Average + SE), a highly significant result (P = 6.9 × 10 -8 , double tailed t test).

When combined with the discovery cohorts, random effects meta-analysis also supports the interaction (β = 0.12, P = 0.027) being highly significant based on the Han/Eskin model ( P = 6.9 × 10 −8 ).

Within the binding regions of the 25 most significantly up-regulated genes linked to a GW7647-induced PPARα binding region, we identified a highly significant ( p = 6.94 × 10 −8 ) module composed of the TATA binding protein (TBP, O$TBP) in combination with the PPAR binding motif V$PERO ( Figure 5 A).

Oligomers also induced very low level, but highly significant, toxicity to astrocytes ( p = 6.968E − 8), and this was prevented by TLR4 antagonists (RSLA; p = 7.746E-8, TAK242; p = 8.103E − 8, Fig. 6 cii).

For instance, the highly significant cotargeting miRNAs miR-124 and miR-9 had strongly correlated expression patterns (R Spearman = 0.82, P = 7 × 10 −8 ).

In agreement with these findings, we observed a highly significant relationship between A3B expression and p53 mutational status in the METABRIC ( P = 7.0 × 10 −8 ) and TCGA ( P = 2.2 × 10 −16 ) breast cancer cohorts (Figure 1A ).

While this failed to surpass Bonferroni correction, the p -value across stages was highly significant (rs823128, p =7.3×10 −8 ) and it is worth noting that the significance improved for all SNPs at this locus when combining stage I and II results ( Figure 2C ).

3c ) and a less strong yet still highly significant directional effect of intelligence on BV ( b xy = 0.139, SE = 0.026, P = 7.34 × 10 −8 ; Fig. 3d ), suggesting a bidirectional association between these phenotypes, in line with the previous reports 53 .

Highly significant enrichment was uniquely found within the first quartile of ranked genes, including metabolic ( P < 7.4 × 10 -8 ), post-translational modification ( P < 9.7 × 10 -5 ) and developmental ( P < 1.3 × 10 -6 ) processes (all Benjamini-Hochberg adjusted).

The clusters are highly significant in predicting survival (likelihood ratio = 37.0; p = 7.6×10 −8 ), also accounting for clinical and histopathological information (age, stage and cancer type; Methods), showing that considering the mutation data and their interactions provides a more complete and informative picture of tumours and their progression.

A third highly significant SNP ( p < 7.60 × 10 −8 ) was located on chromosome B04 (AX-147248780) at positions around 130738535 with 20 candidate genes within proximity, including several disease resistance proteins (TIR-NBS-LRR) ( Arahy.RGV79Z , Arahy.27BWBV , Arahy.QZS0X1 , Arahy.IB6E9K , Arahy.IB6E9K , Arahy.27QVSF , Arahy.EG26MQ , Arahy.

We observed a highly significant association of SNP rs7301743 in TBX3|MED13L with a 0.071 mV (95% CI, 0.038–0.11 mV) smaller voltage of the R wave in V5 per minor allele copy (P = 7.635 X 10 −8 ).