“highly significant”

Chi-square test showed that the association of number of exposures to the risk of alloimmunization was highly significant ( P = 6.843e-9).

The most highly significant estimate corresponded with the downregulation of PINX1 (z = -5.79, p = 6.89E-9), a potent inhibitor of telomerase [ 37 ].

The resulting test of diversifying selection acting on the duplicated Steep1 was highly significant ( P = 6.95E−9).

A highly significant inverse correlation was observed between 8-oxodG level in sperm DNA and sperm concentration ( r = −0.52; p = 0.000000007) ( Figure 2A ), for the whole study population.

Classification Results In logistic regression analysis using the 150 best signal features, the difference in MCG findings between STEMI and control patients was statistically highly significant ( p = 0.000000007) ( Figure 4 ).

In addition, module membership (MM) of the individual genetic features in the Green module demonstrated a highly significant correlation with their respective gene significances (GS) for the cancer trait ( r = 0.75, P = 7.1 × 10 −9 , Figure 3C ).

We found a highly significant increased frequency of mutations in familial cases compared to nonfamilial cases ( P = 7.1 × 10 −9 ).

This difference from 90° was highly significant (one-sided p = 7.5 × 10 −9 , Wilcoxon signed-rank test vs. 90°, Figure 2 J), revealing that, as in the locust, odor ON and OFF responses in mouse OB glomeruli are inverted relative to each other.

The effect was strong and highly significant (Mann–Whitney U test p value = 7.6 × 10 −9 ).

The negative correlations between the coselection scores and SPL were highly significant in all four groups ( P = 7.8 x 10 − 9 , 2.9 x 10 − 9 , 2.9 x 10 − 9 , and 6.7 x 10 − 12 for YRI, EAS, CEU, and combined, respectively).

Eleven of the 21 genes were also found in a list 180 genes compiled from published PCa outcome signatures (Additional file 2 ), which is a highly significant enrichment ( P -value = 7.9e-9, Fisher’s exact test), especially when considering that no gene information was used to infer our signature.

In the subsequent age group of 4–6 years ( n = 80), the mean ratio (1.22 ± 1.58) was slightly below the meta-mean (1.54), showing marginal statistical significance in parametric testing ( t -test, p = 0.074), yet highly significant differences emerged with non-parametric methods (Wilcoxon test, p = 8.03 × 10 −9 ; Binomial test, p = 3.16 × 10 −12 ), albeit with a relatively smaller negative effect size (Cohen’s d = −0.20).

In GENRA/SLESS one further haplotype was observed, which was not present in Europeans [encoded by HLA-DRB1 *14:04; MAF = 0.005; OR = 0.96]. Omnibus tests showed highly significant associations for amino acid positions 11 and 13 in HLA-DRβ1 ( P = 8.1 × 10 − 9 , P = 7.8 × 10 − 9 , respectively) and case–control status in GENRA/SLESS, but not positions 74 ( P = 0.017) and 71 ( P = 0.20).

The effect of temperature was highly significant in an ANOVA ( P = 8.16E−9), which was corrected for gene variation while the bacteria effect was barely higher than the acceptance level of α = 0.05, due to the smaller effect size ( P = 0.0557).

The overall model was highly significant ( p = 8.18E-09), indicating significant factor effects on the number of axial buds growing from the rootstock.

Notably, although we identified WMG-2 in the predominantly MNA cluster 3, Kaplan-Meier analysis of low-risk tumours in the SEQC dataset (n=322) with WMG-2 demonstrated a highly significant association of low WMG-2 with poor survival (p=8.2 x 10 -9 ) ( Figure 5 D , right).

These differences were highly significant between sessions (Pearson's χ 2 = 46.2, df = 5, p = 8.21e9).

Among the genes overexpressed in LF, 6 were putatively involved in insecticide resistance which represents a highly significant overrepresentation for these genes ( χ 2 with Yates correction for continuity, χ 2 = 33.21 , P -value = 8.29 e- 09 ).

Strain energy as an empirical benchmark for CoA-induced arterial stiffening In the proximal aorta, there was a highly significant main effect of group (ANOVA p = 8.3 × 10−9), with post-hoc comparisons showing that all Prolonged CoA groups exhibited markedly elevated strain energy relative to controls (Fig. 1 ).

1A ); we also observed a highly significant positive correlation (Spearman P = 8.4 × 10 −9 ) between ERBB2 and ERBB3 mRNA expression ( Fig. 1B ).

Mitochondrial DNA content was modestly but significantly higher in 8WVeh skeletal muscle than chow-fed counterparts (32.5 ± 5.5 ng/μl and 17.3 ± 5.4 ng/μl, respectively, P = 0.046), but that difference was highly significant in 16W (92.2 ± 24.1 ng/μl in 16WVeh and 7.5 ± 2.4 ng/μl in chow-fed controls, P = 8.4 × 10 –9 ).

The difference between preoperative and early postoperative mLDFA was highly significant ( p = 8.4e–9), as was the difference between preoperative and final follow-up mLDFA ( p = 4.3e–7).

SPMS was compressed using PCA, now including all patients (except the transitioning patients), resulting in a large and highly significant (p=8.5×10 -9 ) separation over the first principal component ( Figure 4 A ).

The association of the WGS with baseline eGFR was modest but highly significant (B = −1.68 (standard error (SE), 0.29), R 2 adjusted = 0.010; P = 8.6 × 10 −9 ).

Accordingly, the inverse correlation between FASN protein expression and global FASN gene methylation as captured by mean beta value was highly significant ( R = −0.34; P = 8.7 × 10 −9 ; Fig. 2B ), with comparable correlations seen for each individual probe ( Supplementary Table S1 ).