“highly significant”

The overall preference for cortical ripples to lead hippocampal ripples during waking compared to NREM was highly significant ( P = 4 × 10 −9 , χ 2 = 34.5, df = 1).

Significantly, we observed highly significant (p<4×10 −9 ) and positive (R 2 >0.80) correlations between levels of differentially-expressed transcripts identified in the presence of ouabain and K + -free medium ( Fig. 4 ).

Indeed, comparison of genes near Ino2-MN sites with genes near Ino2 ChIP-exo peaks ( 36 ), revealed highly significant overlap (adjusted P -value = 4 × 10 −9 ; labeled INO2* in Figure 3B ).

A highly significant variant, g.10818413 T > C , located in the promoter region of EDN3 , was identified ( P < 4.065343e-09).

Given the large number (>1 × 10 7 ) of highly significant variants following multiple-testing correction ( p < 4.07 × 10 −9 ), we consider a Chi-Square value in or above the 75th percentile across all MESA participants as evidence of ancestry-differentiated allele frequencies.

This effect was highly significant (HR 4.778, 95%CI: 2.837–8.046, p = 4.08x10 -9 ).

The overall distribution difference between the two groups was highly significant (p=4.17 × 10 − 9 ) ( Table 4 ).

This overlap was highly significant by the hypergeometric test, confirming that ZEB1 -correlated genes are likely to be regulated by ZEB1 transcriptional activity (1.5-fold enrichment, p = 4.20 × 10 −09 ).

The difference was highly significant (log-rank p = 4.22 × 10^−9), indicating the model’s classification of patients in terms of likely therapy response correlates strongly with actual survival.

Diseases and functions annotation revealed a statistically highly significant overlap with energy production and lipid metabolism ( P = 4.3 × 10 −9 ).

For this total ingested NP, a highly significant positive linear relationship with dose was obtained (LR, p -value = 4.37 × 10 −9 ) with a multiple R -squared of 0.89 ( Fig. 2C ).

We mapped a highly significant QTL on chromosome 7 for cued immobility ( P = 4.40 × 10 -9 ).

Overall, the enrichment of origins near replication peaks is highly significant ( P = 4.41 × 10 -09 ).

A two-way repeated measures ANOVA revealed a highly significant interaction ( F 1.9, 28.8 = 69.5, P = 4.5 × 10 −9 , Greenhouse-Geisser correction applied) between regions (EVC, VTC, OFC) and property type (visual feature, animacy, valence).

One‐way ANOVA indicated that site ID was a highly significant predictor of diversity variation among samples for the Chao1 index ( F 12,75 = 7.66, p = 4.75 × 10 −9 ), and a marginally significant predictor for the Shannon index ( F 12,75 = 1.87, p = 005).

On the other hand, the average sleep intensity in the dark period between flies fed with the different diets showed clearly observable and highly significant differences (p < 4.76 E-09 ) ( Figure 2B and 3A ), suggesting that sugar-only diet resulted in an increase in rest intensity at “night”.

Association between the nonsense mutation in homozygous condition and the presence of red spots in Girgentana goats was highly significant (Fisher exact test, P = 4.8e-9), even if not complete.

Then, we predicted the responses from cell lines that were not part of the training set, obtaining a highly significant prediction with a Spearman’s ρ of 0.64 ( p = 4.8e‐9; Figure S1 ).

islandica ( p = 0.117), but shell growth was highly significant ( p = 4.8 × 10 −9 ). 4.

Indeed, there was a highly significant overlap between the proteins that increased during the 3 rd trimester and decreased post-partum (13/33 proteins, odds ratio (OR): 98.9, p=4.85e-09, Fisher’s exact test, Figure 4B ) and, conversely, between the downregulated proteins during the 3 rd trimester and the ones upregulated post-partum (13/44 proteins, OR: 29.9 , p=1.73e-05, Figure 4C ).

This analysis revealed that 25 genes were up-regulated 1.5-fold or greater in both Tsc1 LOF and FOXO GOF expression profiles, which represents a highly significant degree of overlap (P = 4.9 × 10 e−009 ) as determined by calculation of the hypergeometric distribution.

A highly significant 20% of the genes targeted by PLZF/RARA have altered expression patterns ( P = 4.99×10 −9 , Fisher exact ) with 11% becoming down regulated and 9% being up regulated upon PLZF/RARA binding ( Figure 2a ).

A number of highly significant associations ( P < 5 × 10 −9 ) were identified in regulatory sequences which are good candidates for causing susceptibility to AS, possibly by regulating ERAP1 expression. pmc-status-qastatus 0 pmc-status-live yes pmc-status-embargo no pmc-status-released yes pmc-prop-open-access yes pmc-prop-olf n

All these reported associations remain highly significant even after accounting for multiple testing using Bonferroni correction and a stringent GWAS P -value threshold (nominally P = 5 × 10 −9 adjusted to 1 × 10 −9 for five individual GWAS).

KEGG analysis of this 372-gene set revealed highly significant NFIB-dependent pathways (focal adhesion p = 5*10 −9 , extracellular matrix-receptor interaction p = 5*10 −8 , axon guidance, p = 5*10 −8 and pathways in cancer p = 5*10 −4 ) shown in Figure 4B .