“highly significant”

A t -test comparing scores against 0 demonstrated that this behavioural effect was highly significant ( t = −8.58, p < 10 −9 ).

Genotyping of 419 psoriasis families further revealed that CCHCR1*WWCC (four SNPs, 2 each in exons 4 and 10) and HLA-Cw*6 allele were associated with psoriasis [4]. A genome scan of the 220-kb region (at chromosome 6p21) across 171 family-based trios of European origin, identified 59 SNPs (18 in coding and 41 in non-coding regions), of which two SNPs (n.7 and n.9 lying 7 and 4 kb proximal to HLA-C, respectively) were found to exhibit highly significant association (p < 10-9 ), sug- gesting these two SNPs as markers for psoriasis sus- ceptibility [37].

3 , Table 1; supplementary material Table S2 ). The gene ontology analysis of the recent human dataset ( Tsankov et al., 2015 ) included few highly significant terms ( P -value <1×10 −9 ) ( supplementary material Table S2 ).

It was found that the proportion of the depressed elderly population in India (18.2%) was significantly higher than the rest of the world (5.4%) and this difference was found to be statistically highly significant (x 2 =770.4 and P =.000000001).

First, two highly significant ( p < 10 −9 ) SNPs were found in the intron of krishah ( kri ), and two additional SNPs with slightly lower significance ( p < 10 −7 ) were found in the 5′ untranslated region (UTR) of kri ( Figure S3 ). kri is tightly clustered with the genes S6k and mad2 ( Figure S3 ).

Furthermore, while V600E BRAF mutations (over 10,000 described) occur in a mutually exclusive manner with RAS mutations, four of the 34 kinase-dead mutants are coincident with RAS mutations, a highly significant enrichment (p < 10 −9 ; Fisher's Exact Test) that suggests functional interaction.

Together these show that four of the genes investigated ( HLA-C, IL12B, TNIP1 and IL23A ) show highly significant differences in expression levels between involved and uninvolved skin (all with p < 10 −9 ).

The transcriptional changes in CE mice were statistically highly significant (ranging from p < 10 -9 to 10 -5 ), and involved ECM processes related to collagen synthesis/modification/assembly and intracellular signaling via the PIP2/PLCg/DAG/IP3 pathway.

We found a highly significant non-random association of non-silent TP53 mutation to HPV negativity (Fisher’s exact test Odds Ratio = 0.14, p < 10 −9 ), suggesting an underlying association, and this was not included in the multivariate analysis.

However, when 1000 WBC were analysed, blasts were detected in 33/37 (89%) of MDS samples compared with 6/30 (20%) of age‐matched controls, a highly significant difference ( p < 10 −9 ).

In the infants with confirmed CMPA, there was a highly significant reduction in CoMiSS from 8 (IQR 6–11) to 5 (IQR 3–7) from baseline to visit 2 (p<0.000000001), with a median reduction by −3 (IQR −6 to −1).

2 A ), as confirmed by the highly significant main effect of window size on MT in a repeated measures ANOVA ( F (8,104) = 176.980, p < 10e-10).

Correlation in log fold-change among genes between the two environments was highly significant ( P = 1 × 10 −9 ) but weak ( r = 0.1).

Knowing that multigenic cRM represent 10% of all cRM (967/9720), 25/76 (i.e., 33%) corresponds to a highly significant three-fold enrichment ( p < 10 −9 ).

Results We detected highly significant associations of obesity with alleles in all three SNPs (p < 10 -9 ).

While the absolute difference in GC content was slight, it was highly significant ( P < 0.000000001).

While the alpha-tocopherol had no effects in delaying disability, the selegiline arm show a highly significant effect in delaying the need for L-DOPA treatment over controls (P > 10 –9 ).

The five most highly significant (FDR P = 1 × 10 −9 ) Gene Ontology (GO) terms for biological process relate to immune system activation and regulation (Supplementary Data 12 ).

These comparisons were also highly significant ( p < 10 −9 for all tests, one-sided Fisher's exact test) for the control participants.

Differences between the study and control groups in our empirically developed type 3c diabetes index were highly significant (full P value < 0.000000001; Table 2 ).

This increase in responsiveness with depth was highly significant ( R 2 = 0.70, p < 10 −9 , linear regression, n = 35 imaged regions in seven mice; Fig. 2 A ; Table 1 ) and was observed in every animal tested ( Fig. 2 A ; Table 1 ; R 2 > 0.79 and p < 0.04 for all animals, n = 5 regions per animal).

By another GEE, we observed the expected highly significant relation ( p < 10 −9 ) between the histology‐based and MRI‐based measurement of cortical thickness (see Fig 5 ).

The Kruskal–Wallis test confirmed highly significant global heterogeneity (H = 94.31, p < 10 −9 ).

De novo MEME analysis (Figure S2A ) reveals that Round 25 aptamers overwhelmingly share a single, contiguous motif that extends across nearly the entire 40‐nt core, with RTAR and its closest relatives showing highly significant full‐length matches ( p < 10 −9 ), whereas the less enriched clusters display only truncated or offset hits to secondary motifs.

A linear model with age as a covariate showed a highly significant effect of the condition (p < 1*10 −9 ).