“highly significant”

In particular, we found a highly significant correlation between WISP1 and GATA3 (p–value<1x10 -9 ) and a highly significant negative correlation between WISP1 and PPARG (p–value<1x10 -15 ).

Results We detected highly significant associations of obesity with alleles in all three SNPs (p < 10 -9 ).

However, TR ratings and investments were highly correlated in both conditions (mean linear correlation coefficient r = 0.65 in EC and 0.61 in CC, corresponding to P -values smaller than 10 −8 in both cases) and correlations were also highly significant between TR ratings and ERs (mean r = 0.72 in EC, 0.69 in CC, P < 10 −9 ).

Third, there was a highly significant three-way interaction between ranked resistance, environmental structure, and time ( P < 10 −9 ), capturing the decrease in filamentation on solid medium over time, which occurred only for low-resistance types ( Fig. 5B ).

It was found that the proportion of depressed elderly population in India (18.2%) was significantly higher than the rest of the world (5.4%) and this difference was found to be statistically highly significant (χ 2 = 770.4 and P = 0.000000001*).

A t -test comparing scores against 0 demonstrated that this behavioural effect was highly significant ( t = −8.58, p < 10 −9 ).

The Kruskal–Wallis test confirmed highly significant global heterogeneity (H = 94.31, p < 10 −9 ).

De novo MEME analysis (Figure S2A ) reveals that Round 25 aptamers overwhelmingly share a single, contiguous motif that extends across nearly the entire 40‐nt core, with RTAR and its closest relatives showing highly significant full‐length matches ( p < 10 −9 ), whereas the less enriched clusters display only truncated or offset hits to secondary motifs.

In comparison to nevi, all types of melanoma demonstrated highly significant reduction in ciliated cells ( P < 1 × 10 −9 by Tukey test).

First, two highly significant ( p < 10 −9 ) SNPs were found in the intron of krishah ( kri ), and two additional SNPs with slightly lower significance ( p < 10 −7 ) were found in the 5′ untranslated region (UTR) of kri ( Figure S3 ). kri is tightly clustered with the genes S6k and mad2 ( Figure S3 ).

In the infants with confirmed CMPA, there was a highly significant reduction in CoMiSS from 8 (IQR 6–11) to 5 (IQR 3–7) from baseline to visit 2 (p<0.000000001), with a median reduction by −3 (IQR −6 to −1).

When we compared the hu.MAP 2.0 interactions to the most co‐expressing pairs in Kustatcher et al , we see a highly significant overlap ( P ‐value < 10E−10, hypergeometric test) indicating a high degree of consistency between the orthogonal datasets. hu.MAP 2.0 complex map Once we confirmed our protein interaction network was of high quality, we then clustered this network using a parameterized two‐stage clustering algorithm to identify highly connected proteins which represent protein complexes.

Of the 677 genes with SV-expression associations at p < 0.01 for 1 Mb region (linear model adjusting for covariates) across the CBTN cohort, 126 were also associated with patient overall survival ( p < 0.05, Cox incorporating histologic type) in the same direction (e.g., genes both higher with SV breakpoints and higher in patients with worse survival), representing a highly significant overlap ( p < 1E-9, chi-squared test, Fig. 5a and Supplementary Data 7 ).

We found a highly significant non-random association of non-silent TP53 mutation to HPV negativity (Fisher’s exact test Odds Ratio = 0.14, p < 10 −9 ), suggesting an underlying association, and this was not included in the multivariate analysis.

This increase in responsiveness with depth was highly significant ( R 2 = 0.70, p < 10 −9 , linear regression, n = 35 imaged regions in seven mice; Fig. 2 A ; Table 1 ) and was observed in every animal tested ( Fig. 2 A ; Table 1 ; R 2 > 0.79 and p < 0.04 for all animals, n = 5 regions per animal).

Not surprisingly, consistent with the change in σ B 0 Global given in Table 1 , significance testing on a per‐pixel basis (388,257 gray‐matter pixels, from n = 8 subjects) showed that the reduction in B 0 offset is highly significant (paired t‐test, P < 10 ‐9 ).

The transcriptional changes in CE mice were statistically highly significant (ranging from p < 10 -9 to 10 -5 ), and involved ECM processes related to collagen synthesis/modification/assembly and intracellular signaling via the PIP2/PLCg/DAG/IP3 pathway.

While the alpha-tocopherol had no effects in delaying disability, the selegiline arm show a highly significant effect in delaying the need for L-DOPA treatment over controls (P > 10 –9 ).

2 A ), as confirmed by the highly significant main effect of window size on MT in a repeated measures ANOVA ( F (8,104) = 176.980, p < 10e-10).

6B , the predictions were highly significant at the whole-cortex level ( r =.64, p <10 −9 ).

Sets of 1,049 and 969 genes (out of the total of 14,405 represented on the microarray), were found to be modulated in hippocampus and cortex, respectively, the intersection of the two sets consisting of 619 genes, a highly significant number (P<10 −9 ) ( Figure 5A ).

Among all the modules, the turquoise module showed a highly significant association with fibrosis and inflammation levels ( P = 1 × 10 −09 for fibrosis stages and P = 1 × 10 −10 for inflammation grades).

Correlation in log fold-change among genes between the two environments was highly significant ( P = 1 × 10 −9 ) but weak ( r = 0.1).

By another GEE, we observed the expected highly significant relation ( p < 10 −9 ) between the histology‐based and MRI‐based measurement of cortical thickness (see Fig 5 ).

Voxel values in these clusters were highly significant and two ROIs were created from the binarized clusters with a T statistic threshold T = 7.0 ( p = 1 × 10 −9 ) for the sensorimotor ROI ( Figure 1 B), and T = 5.0 ( p = 2 × 10 −6 ) for the subcortical ROI ( Figure 1 C).