“highly significant”

We found a highly significant positive correlation of number of hits per target site with motif score (Spearman's correlation, ρ = 0.154; P < 2.2 × 10 −16 ) and weak positive correlation with palindrome score (Spearman's correlation, ρ = 0.029; P = 0.003).

While the p -values are highly significant ( p -value < 2.2e–16), this is likely due to the large sample size, and the relationship between TE content and gene expression is rather weak (Fig. 3 G), suggesting that genes can be highly expressed despite containing substantial intronic TE densities.

magna SGR and was highly significant ( p < 2.2 × 10 −16 ; see Table 2 for additional information).

We observed a highly significant rate of concordance and overlap between cerebellar expression profiles of Atxn1 −/− and Atxn1 154Q /+ mice (z = 11.9485, P -value<2.2e-16, Kendall-τ test).

This comparison also revealed highly significant, albeit slightly weaker correlations (Pearson correlation 0.73; P <2.2e-16; Figure S11 ) – similar to the results we obtained for chromosome 1 CNVs.

Comparing the probeset response slopes predicted by our model with the slopes obtained from the Affymetrix tissue panel data, we detected a highly significant correlation both in mouse and human (Pearson correlation coefficient in mouse 0.528, P << 2.2 × 10 −16 , and in human 0.468, P << 2.2 × 10 −16 ).

Actually, there was a highly significant positive correlation between the number of FGs and KOs ( R = 0.71, p < 2.2e −16 ) (Supplementary Fig. 8 ).

The overlap was highly significant ( P < 2.2 × 10 −16 ).

We observed a highly significant gain of methylation with age at the locus in the LBC cohort, validating our approach (Fig. 1 a, T-test, p < 2.2 × 10 −16 ).

Based on paired t -test, we showed that the exponential regression model had highly significant mean R 2 accuracy than each of the existing methods (Holsteins: t = 584.8–37281; p < 2.2–16; Jerseys: 1178.5–5861.4; p < 2.2e-16).

The enrichment for tryptophan-depletion-induced W>F peptides (44 versus 4) is highly significant, considering the globally reduced protein expression ( P < 2.2 × 10 −16 ; Fig. 2b, d ).

A comparison of activation strength in both assays revealed an intermediate (Pearson's correlation coefficient of 0.58) but highly significant correlation ( P < 2.2e−16) of activation values ( Figure 1B ).

Given this trend, we fitted a logarithmic model to the data, which was highly significant [linear regression F ST ~ log( D a ), P < 2.2 × 10 −16 ; Pearson correlation coefficient, R 2 = 0.96].

Analysis of variance showed that the genotypic (G) and the year (Y) effects for fruit weight were highly significant for each population ( P values < 2.2e-16).

Our results demonstrate that subtype indicators are highly significant in predicting survival ( p -value < 2.2 × 10 −16 ).

When the test was conducted with results adjusted for cohort, PCs, age, and gender, the over-representation of risk associations remained highly significant ( p value < 2.20 × 10 −16 ).

Remarkably, we found a highly significant increase in entropy in the converging sites of 0.005 increase in entropy per decade of age ( p value < 2.2e −16 ), and a stark contrast with the diverging sites, which significantly decrease entropy with age, and could be considered “anti-entropic” since they become more predictable with age (Fig. 5 B).

A highly significant statistical difference (X-squared = 1715.4, df = 180, p -value < 2.2 × 10 −16 ) was found between the frequency combinations of the two haplotype sequences. 3.5.

High phenotypic correlations were observed for both females ( r = 0.98) and males ( r = 0.95), with highly significant p values ( p < 2.2 × 10 −16 ).

The observed overlap was highly significant ( P value < 2.2 × 10 −16 ), indicating strong concordance between the 2 datasets.

2 A), which was still highly significant ( p = 2.2e-16) due to the number of data points.

The correlation of the concentrations determined by 1 H-NMR and by quantitative methods were highly significant for both the samples of ccDMEM (Pearson: r = 0.99, p = 2.20 * 10 −16 ) and of vcDMEM (Pearson: r = 0.91, p = 2.84 * 10 −6 ).

Among these were 20.0% of the genes upregulated in XY° males (993 out of 4973) versus 40.8% of the genes upregulated in XX females (3856 out of 9472) in at least one developmental stage (FDR < 0.05), a highly significant difference ( χ 2 = 330.0, p < 2.2e−16).

0.00276, Fisher's exact test p-value = 1.34e-05), there is a highly significant excess of sites supporting the species topology (0.00229 vs. 0.00210, Fisher's exact test p-value < 2.2e-16) and deficit of sites in these regions supporting ILS topologies (0.00042 vs. 0.00066, Fisher's exact test p-value < 2.2e-16, Fig 2B and 2C ), which suggests that the observed reduction of ILS is not the result of a lower mutation rate.

The sequencing data showed highly significant expression correlation with the array data ( R = 0.88, p < 2.2 × 10 −16 ) for 101 genes whose expression was significantly altered in KO mouse (Table S3 and Figure S8 ).