Barely Significant
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“extremely significant”

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In the literature

No proof has ever been adduced for this position, and it is extremely significant that convincing evidence is still wanting to support the view that such endotoxins are responsible for, or capable of, stimulating the production of antibodies along the lines which hold for the reaction of the animal organism against the diphtheria exotoxin.
Book Reviews
Edinb Med J · 1922 · PMC5316582