Barely Significant
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“extremely significant”

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These capabilities are extremely significant for long-term imaging of biological systems, which will not only allow the human eye to directly identify information about particular nanoparticles via a simple microscopic inspection but also initiate an effective method to investigate the complicated biological microenvironment by utilizing a single-particle technique in physiologic and pathologic processes in living conditions.
Intergroup Comparison of Microhardness at Baseline The difference in microhardness between group I and all other groups was extremely significant ( Table 2 ) demonstrating porous enamel prism structure after production of enamel caries requiring immediate attention and remineralization.
Based on the hypergeometric distribution (all possible drug-disease pairs in CTD is 5239086, the number of positive pairs in CTD is 111481, the total number of drug-disease pairs considered 6260 and the number of positive pairs is 514), the result is extremely significant ( p -value is 6.19 × 10 −144 ) and shows that the top ranked predictions by iDrug are greatly enriched in the CTD dataset.
Both at 2 and 6 months, the concentrations of Annexin 2 ( P = 0.00031 and P = 7.1E-05, respectively) and Clusterin ( P = 5.7E-07 and P = 1.7E-06, respectively) from urinary exosomes in the control group were extremely significant higher than that in 5XFAD mice group ( Figures 9B,C ).
The variation coefficients of other heavy metal elements are all greater than 0.3, showing a relatively obvious spatial distribution difference, among which the variation coefficient of Hg is the highest as 4.13, indicating that the spatial distribution difference of Hg element in the topsoil is extremely significant.