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“extremely significant”

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The eWOM communication of tourist attractions is extremely significant, not only because it determines the consumption behavior of potential tourists (Zhu et al., 2015 ; Mohammed Abubakar, 2016 ; Jalilvand and Heidari, 2017 ) but, more importantly, it is a more trustworthy information source, which has a more powerful communication effect than tourism enterprises' propagation.
All three of these reports are extremely significant events for researchers concerned with finding practical treatments for AD and PD, since they demonstrate, for the first time, that chronically reducing just one parameter, cerebral TNF levels, can alter the frequency of onset of these two important neurodegenerative states.
Hence, it is extremely significant to monitor industrial land and intra-structure dynamics for industrial land management and industry transformation, but it is still a challenging task to effectively distinguish the internal structure of industrial land at a fine scale.
25 Chemotherapy may cause irreversible ovarian damage, so the fertility preservation of women of childbearing age and adolescent women during the anticancer period is extremely significant. 6 However, fertility preservation methods recommended by the American Reproductive Medicine Association are to preserve the couples' embryos and the female oocytes. 26 Although hormone replacement therapy can be used for a long time to relieve symptoms, it can not prevent its occurrence and progress. 27 Besides, ovarian tissue transplantation and stem cell transplantation can not cure POI, due to their poor prognosis and uncontrollable long‐term results. 28 Therefore, it is urgent to find a new clinical treatment strategy for POI patients.
These expressions were significantly increased after blocking with anti-integrin α5 and anti-integrin β1 compared to the LIF– group, and all three pluripotent genes simultaneously exhibited extremely significant expression increases in the anti-integrin α5+β1 group ( Figure 6C ).