Barely Significant
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“did not reach statistical significance”

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Although red blood cell (RBC) transfusion in the ward (OR: 10.662, 95% CI: 0.877-129.597, p=0.063) and in the operating theatre (OT) (OR: 2.175, 95% CI: 0.942-5.021, p=0.069) were associated with trends toward increased mortality, these associations did not reach statistical significance. Secondly, among variables analyzed for association with infection, RBC transfusion in the ICU (OR: 1.426, 95% CI: 1.044-1.948, p=0.025) and fresh frozen plasma (FFP) transfusion in the ICU (OR: 1.448, 95% CI: 1.052-1.993, p=0.023) were significantly associated with an increased risk of infection.
In addition, although the global analysis did not reach statistical significance, it is interesting to note that layer III of area 36c exhibited a gradual decrease (42%) of neuron number between birth and adulthood ( p = 0.025), which resembled that observed in layer III of areas 35 and TF (see below). 3.2.2 Parahippocampal Cortex 3.2.2.1 Subdivisions The number of neurons differed between age groups in area TF ( F (3,12) = 5.496, p = 0.013, η 2 p = 0.579), but not in area TH ( F (3,12) = 1.087, p = 0.392, η 2 p = 0.214; subdivision × age group: F (3,12) = 4.777, p = 0.020, η 2 p = 0.544).
Regarding combinatory genotypes and haplotypes, though the differences in HDP cohort did not reach statistical significance after adjustment for multiple comparisons, it is still of interest that the T-S haplotype ( p = 0.025) or the SL-AT genotype ( p = 0.048) displayed a tendency to be lower in HDP patients.
Efficacy ORR was 82.5% (95% CI, 76.9-87.2) in the once-weekly KRd56 group vs 86.3% (95% CI, 81.1-90.5) in the twice-weekly KRd27 group (risk ratio [once-weekly KRd56/twice-weekly KRd27] = 0.954 [95% CI, 0.882-1.032]; P = .0666; Table 2 ), which did not reach statistical significance for noninferiority at the prespecified alpha threshold of P ≤ .025, 1-sided.
Although node strength differences did not reach statistical significance after Bonferroni correction, the effect size suggested a trend of reduction in ipsilateral pulvinar (uncorrected p = .025, corrected p > .05, Cohen d = .56), consistent with findings in the overall focal epilepsy group.
Plasma oxidative stress markers Changes of plasma m-tyrosine levels after exposure to air contaminants did not reach statistical significance (Fig. 6a ), while o-tyrosine (Fig. 6b ; 3-way ANOVA, Ozone × EHC-93, p = 0.025; 2-way ANOVA, Ozone × EHC-93, p = 0.040) and p-tyrosine (Fig. 6c ; 3-way ANOVA, Ozone × Recovery, p < 0.001, EHC-93 main effect, p < 0.001; 2-way ANOVA, EHC-93 main effect, p = 0.010) were affected by both pollutants.
However, the observed effect did not reach statistical significance, likely attributable to substantial heterogeneity among studies (I 2 = 72.9%, p = 0.025, 95% CI: −0.37–1.36) ( Figure 5 ). 3.4.4 Effect of PR combined with IMT on FEV 1 % in older COPD patients The meta-analysis of four RCTs demonstrated a moderate effect size (SMD = 0.58) for improvement in FEV 1 % with PR combined with IMT compared to PR alone in older COPD patients.
The incidence of major depressive episode was also associated with lesion volume in the left orbital prefrontal network ( P = 0.037), our secondary hypothesis, but this comparison did not reach statistical significance after Hochberg's multiplicity adjustments ( P = 0.025).
Steep AK and steep TK increased (0.06 ± 0.26 D and 0.07 ± 0.29 D, respectively; all p = 0.005), leading to an increase in ACA and TCA, although the change in TCA did not reach statistical significance (0.06 ± 0.35 D, p = 0.026 and 0.06 ± 0.38 D, p = 0.054, respectively) (Table 3 ).
For all three antigens, we detected a positive correlation between development of memory B cell responses and increases of avidity indices of IgA and IgG antibodies on corresponding study days (Spearman, r = 0.32 to 0.6, P = 0.003–0.1), although correlation for IgG responses to CS6 did not reach statistical significance and correlation for LTB specific responses were weak (Spearman, r = 0.323 to 0.338, P = 0.026–0.054) ( Table 2 ).
Using univariate analysis, 3 predictive factors for being a responder were identified individually (the other tested variables did not reach statistical significance in predicting treatment outcomes): IGIc–IH1 at the end of the 3 mg/kg/day regimen (OR = 22.9, 95% CI [1.2–1844.1], p = 0.026), a treatment duration of at least 3.5 months at 3 mg/kg/day (OR = 17.5, 95% CI [1.22–250.37], p = 0.041), and of at least 7 months at doses > 3mg/kg/day, ranging from 3.75 to 4 mg/kg/day (OR = 17.5, 95% CI [1.22–250.37], p = 0.041).