Another nearby gene, PPBP (encoding Pro-Platelet Basic Protein, also known as CXCL7), was also up-regulated in convalescent samples, although it did not quite reach significance at 1% FDR (nominal P = 3.3 × 10 -5 , Benjamini-Hochberg adjusted P = 0.016).
However, while PCs in Df(h15q13)/+ mice displayed a clear reduction in mean firing rate during the steady‐state phase for the frequency interval tested (20–80 Hz), interneurones only showed a tendency towards reduced mean firing which did not quite reach significance (mean firing rate for PCs and FSIs in mutants was on average: 45.5% and 94.5% of those in wt mice; anova main effect of genotype, P < 0.001, F = 20.13 and P = 0.0586, F = 3.59 respectively; post hoc test showed a significant genotype difference for PCs for all frequencies except 20 Hz; Fig. 3 a–d).
Treatment with quercetin was able to inhibit KCC activity both before and after NEM treatment, although the latter did not quite reach significance ( Figure 3B , p < 0.01 and p = 0.07).
6 b, c) but did not quite reach significance (Atrogin-1: F 3,24 = 6.5, P < 0.01; MuRF1: F 3,24 = 3.4, P = 0.035).
Pairwise comparisons showed that the number of landmark-based choices was significantly greater than that of incorrect choices, Pearson chi-square test: χ 2 (1) = 15.21, P < .0005, but did not quite reach significance compared with geometry-based choices, Pearson chi-square test: χ 2 (1) = 5.44, P = .02.
However, the increase in the ratio of pNF-κB/ NF-κB in the combination treatment group did not quite reach significance (control 0.59 ± 0.12; H398, 0.69 ± 0.13; EHD-sc-mTNF R2 1.00 ± 0.03, p = 0.0245; H398 + EHD-sc-mTNF R2, 0.94 ± 0.057) (Fig. 4 J–L).
There was also a tendency for subjects to spend less time looking up after hearing ‘pyows’ alone than if they had first heard eagle shrieks or the sound of a falling tree although this difference did not quite reach significance in pair-wise post hoc tests (‘pyows’ alone vs. eagle-‘pyows’, T + = 15, N = 6, p = 0.031; ‘pyows’ alone vs. tree ‘pyows’, T + = 15, N = 6, p = 0.031; eagle-‘pyows’ vs. tree-‘pyows’, T + = 9, N = 6, p = 0.422, post hoc Wilcoxon signed ranks tests).
For TKA participants who did not rest (n = 20), the difference between 6MW speed and 30MW speed was minor and did not quite reach significance (1.34 m/s vs 1.38 m/s, P = 0.05).
A small-to-moderate group effect size was seen between COPD and HCs for PWV, although this did not quite reach significance (partial eta squared = 0.05, F=4.0, p =0.050) (see Table S3 ).
When sub-grouped, again, only the periphery placentae appeared lower in both the early- and late-onset pre-eclampsia groups, but they did not quite reach significance ( p = 0.05; Table 2 ). 2.4.
Spiking also increased with carbamazepine, although this did not quite reach significance ( p = .05).
For LF-HRV there was a significant negative correlation with working memory accuracy in the during-tDCS task period (r = -0.50; p = 0.024), however, this association did not quite reach significance in the post-tDCS task period (r = -0.44; p = 0.050) – see Fig 5 .
The effect for subscale 4 was similar, though this test did not quite reach significance ( F (1, 292) = 3.88, p = 0.05).
There was a trend towards a lower incidence of bile leak following TC when compared to TD stone extraction, however, this did not quite reach significance (1.2% vs 5.0%, p = 0.0504).
While sex was included as an independent term in the best model (Table 1 ), the correlation between the sex of the badger and the frequency with which they made ETEs did not quite reach significance (P = 0.0506, Table 2 ) across the whole year, although the trend was towards males making, on average, more frequent ETEs throughout the year (Fig. 4 – mean values).
For group 2, portable ERG peak times were on average 1.8 ms and 2.1 ms longer than those for conventional ERGs for right and left eyes, respectively, but the difference did not quite reach significance ( P = 0.0506 and P = 0.0797 for right and left eyes, respectively).
Grading the CE severity revealed that at T 0 + 6 months, CE scores in compound mutant mice tended to be higher than in single mutant mice but did not quite reach significance ( P = 0.0507, Figure 5B ).
Patients with patch repair of the diaphragmatic defect also had considerably more moderate or severe GER symptoms than patients whose diaphragmatic defect was repaired primarily, but this did not quite reach significance ( p = 0.051).
5 o, Table 3 ), but did not quite reach significance ( p = 0.051) in the WH group.
When the data were analyzed separately by sex, the effects of ELS on immobility time in males did not quite reach significance [ F (1, 41) = 4.077, p = 0.051], but a history of MS did significantly increase time spent immobile in females [ F (1, 34) = 5.681, p = 0.023].
A similar trend was also seen in those with obstructive symptoms all this did not quite reach significance ( p = 0.051, Table 2 ).
Similarly, agrin protein was significantly increased in both Egr-1−/− mouse diaphragm (full length, p = 0.029; 110 kDa, p = 0.0027; 90 kDa, p = 0.001; 22 kDa, p = 0.007; Figures 4B,C ) and soleus muscles (110 kDa, p = 0.0464; 90 kDa, p = 0.0023; 22 kDa, p = 2.93 × 10 −5 ; Figures 4D,E ) compared to controls, with the exception of soleus full-length agrin which did not quite reach significance (full length, p = 0.051).
The Context by Compatibility interaction did not quite reach significance ( p = .051), and the Bayesian analyses provided strong evidence in support of the null hypothesis ( BF = 23.551 ± 6.4%).
The DTSQc also showed a greater responsiveness than the DTSQsDiff to Treatment differences (Questionnaire × Treatment interaction), although this did not quite reach significance on the ranked (two-tailed) test (p = 0.051).
A positive effect of experiencing the musicians live on movement entrainment did not quite reach significance, t (66) = 1.99, p = 0.051 (Supplementary Table S14).