Barely Significant
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“clearly significant”

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In the literature

We can see that the C=O group is oriented such that the oxygen atom interacts with the collection of convergent CH protons in the cage binding pocket, with several CH⋅⋅⋅O contacts from naphthyl CH and methylene CH 2 protons having H⋅⋅⋅O separations in the range 2.46–2.98 Å; individually weak but cumulatively clearly significant (Figure 2 b).
However, the difference between the rats that self-administered a drug and those of saline serum is clearly significant, demonstrating that the C+E combination is a clear reinforcing stimulant for animals of both sexes, and that the presence of ethanol does not diminish cocaine’s reinforcing properties, at least in laboratory rodents and in the specific conditions of this study.