Using a large real‐life, prospective, and UK‐wide cohort of patients with RA, we did not detect any difference in the efficacy between adalimumab and abatacept and only borderline significant associations with Val11 but not the SE.
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“borderline significant”
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p=0.09
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Associations became borderline significant after adjustment for confounding factors.
A borderline significant association was also found with high fish consumption (OR Q4 versus Q1 = 0.80, CI 95%=0.63−1.01).
However, the benefit of chemoradiotherapy seen in this later study was much smaller and only borderline significant[ 34 ].
The results were considered statistically significant at p < 0.001, and p -values between 0.05 and 0.001 were considered borderline significant.
Finally, it is noteworthy that despite some sex-specific metabolite changes, many of them also displayed changes in the same direction in both sexes, even though they were borderline significant.
HR 3.17; 95 % CI, 0.99–10.16) with second hip fracture were borderline significant.
This finding is consistent with a prior Seattle-Puget Sound case-control study, which identified a borderline significant risk reduction for lobular breast cancers among women using ACEis for 10 years or longer (RR = 0.6, 95% CI: 0.4-1.0) [ 2 ].
Baseline sVEGFR2 was borderline significant as a prognostic marker for PFS, OS and time to first skeletal event.
For multivariate analyses, aircraft noise levels were not related to the morning concentration of cortisol, but were associated with an increase in evening cortisol concentration (exp(β) = 1.08, CI95% 1.00–1.16 for a 10-dB(A) increase in LA eq,16h ; exp.(β) = 1.09, CI95% 1.01–1.18 for a 10-dB(A) increase in L den ; exp.(β) = 1.11, CI95% 1.02–1.20 for a 10-dB(A) increase in L night – while the relation between evening level and LA eq, 24h was borderline significant exp.(β) = 1.08, CI95% 1.00–1.17 per 10-dB(A) increase) in women.
In our results, clearer decrease in cystitis incidence was observed in primary care than in secondary care, but the decrease in secondary care was borderline significant.
However, the synergistic effect between class 2 (moderate adversity clustering) and depression was only borderline significant for the weighted GEE with untrimmed overlap weights and unweighted GEE models 1 .
Significant or borderline significant overall dietary effects were observed in 9 out of 16 tested CpGs, with consistent decreases in methylation by FASD ( Figure 10 ).
In the 5′ region of Rh2a/b there were alleles that had borderline significant univariate associations with severe malaria (in the intron and the microsatellite centred on codon 747), but these did not remain significant after adjustment for potential confounding by the logistic regression analysis ( Table 3 ).
A multivariate logistic regression model was used to identify predictors for treatment response; we included variables that were statistically significant or borderline significant between the two groups (responders versus non-responders).
In the multivariate models, the outcome for smoking (highly significant) and duration of symptoms (borderline significant) were generally the same with all inflammatory biomarkers, and is thus shown only in the first model with hsCRP.
Deciduous leaves exhibited significantly higher P:M and lower S:P and θ IAS , with SA mes(S+P) also showing a borderline significant increase ( Fig. 4b ; Supplementary Table S4 ).
Statistical significance was set at a level of 0.05, p -values between 0.05 and 0.1 were considered borderline significant.
For subjects with NED, Diabetes and Arteriosclerosis showed borderline significant association to false positive Sept9 results.
We also found an approximately two-fold relative risk (borderline significant) for CML in relatives of MPN patients.
30 However, we noted that the effect of rs6295 on T2DM comorbid with DDM risk was pronounced at genotype frequencies (p = 0.062), although there was only a borderline significant difference.
Autologous cell therapy using CD34 + cells for critical leg ischaemia (ACT34-CLI) [ 4 ] showed a borderline significant decrease in the limb amputation rate after intramuscular application of a high dose of G-CSF-mobilised CD34 + cells, thus indicating the number of transplanted stem cells to be one of the important factors of successful treatment.
While contact volume per week was significantly associated with pain in the unadjusted model (2.79 hundreds per week among the NTP group vs 2.28 in the no-NTP group; P = .022), this result became only borderline significant after adjusting for weight lifting and years playing.
Parents living urban municipalities were less likely to report being satisfied with their received support for parenthood but the result was only borderline significant for parents who gave birth (OR 0.74, 95% CI 0.55-1.00) and non-significant for the other parents (OR 0.66, 95% CI 0.43–1.01) (Table 3 ).
In overall PBMCs, the normalized PHA + /PHA − ratio evidenced a borderline significant ROS decline upon 6M follow up ( Figure 4 ). 2.3.