MR analysis confirmed that downregulation of PRR4 expression is a risk factor for CRSwNP (OR = 0.99951, P = 0.04280), with the caveat that the very small effect size and borderline significance indicate limited evidence strength at present.
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“borderline significance”
In the literature
After adjusting for age and menopause, 11OHT and 11KT remained significantly lower (p adj <0.001, 0.003, respectively), while T showed borderline significance (p adj =0.08).
To ensure robustness, sensitivity checks were conducted by refitting the regression model after excluding variables with borderline significance or potential sparsity, and the direction and magnitude of effect estimates remained unchanged.
As expected, both CFS and fibromyalgia patients reported less current activity than healthy controls, but small sample sizes and Bonferroni's corrections resulted in borderline significance for some of the sub-group comparisons.
In addition, a borderline significance was observed for SHBG.
Interestingly, 3 factors linked with higher mortality (that is, age at diagnosis ≥65 yr, disseminated infection and vascular involvement) emerged from our pooled analysis, although some of these associations showed only borderline significance.
Of these, only 14% were also reported by the school at full significance, and 28% at borderline significance.
HDL-C levels were inversely associated with NC quartiles in both sexes with borderline significance.
In multivariate Cox analysis 1, the variables that remained significant were sex, NYHA class, TS, and IAA, with LVEF showing borderline significance.
Clinically important variables with borderline significance, such as chronic kidney disease and solid organ malignancy, were also entered into the multivariable logistic regression for evaluation.
Echocardiographic evaluation of ejection fraction revealed a significant improvement during ivabradine therapy for HCM patients and borderline significance for the other groups ( Figure 3(b) ).
In addition, a borderline significance was demonstrated in stage II patients.
The MDS resulted equally in higher values when applied on the vegetarians compared to the omnivorous subjects, reaching only borderline significance.
These animals also showed increases in the loads of NVT33 (PspA1) with borderline significance.
Variables were selected for inclusion in the multivariable model on the basis of established clinical relevance from the published literature on infection after implant-based breast reconstruction, supplemented by statistical significance or borderline significance in the univariate analysis; no automated selection procedure was used.
Multivariable analysis ( Table 6 ) showed that ΔTSH (TP2-TP1) is a significant predictor of hypothyroidism (OR 1.3, 95% CI 1.07–1.57, p = 0.007) together with Anti-Tg Ab positivity (OR 9.3, 95% CI 0.99–87.95, p = 0.051), even though this predictor has borderline significance.
In the sensitivity analysis, a high stable trajectory pattern was still significantly associated with an increased risk of CRC, and an upward trajectory pattern was associated with a borderline significance level ( Supplementary Table 2 ). 3.
Although “entire stomach” tumor location showed borderline significance in multivariable analysis, our subgroup analysis suggested potential heterogeneity by sex ( Supplementary Figure S3 ).
Chronic kidney impairment (GFR < 60 mL/min) was also associated with a higher risk (HR: 1.406; 95% CI: 0.964–2.052), suggesting a possible link between renal dysfunction and cancer susceptibility, although the confidence interval crosses 1.0, indicating borderline significance.
While COPCOV suggests a modest signal in prophylaxis (RR ~0.85, borderline significance) [ 5 ], this effect is small, non‐clinically relevant (1% vs. 1.2%), and inconsistently observed across trials.
There was borderline significance between the groups in depression, which was expected based on the overlap in depression and apathy symptoms.
Furthermore, the development of vulnerable plaque (mixed or noncalcified types) was larger in the MS group than group without MS with borderline significance (Table 2 ).
Univariate and multivariate analyses confirmed sepsis, malignancy, and (with borderline significance) heart failure as independent predictors of mortality.
However, NANOG gene expression was upregulated in both NTERA-2 CisR and NCCIT CisR cell lines at borderline significance levels.
Other limitations include the small sample size, particularly for certain patient groups, which sometimes led to borderline significance and an increased risk of overstatements, as well as the inability to control for potential confounders.