“borderline significance”

injection of HA-HL was rapidly achieved and the statistically significant between-group differences in pain intensity in favor of HA-HL in our study approached or exceeded the 5 mm difference, which is considered clinically relevant for symptomatic slow-acting drugs for OA (SYSADOA) [ 27 ], at most time points, and was significantly in favor of HA-HL at all time points, except for week 18, when it reached only borderline significance.

In a multivariable regression analysis assessing each PA type, adjusting for age and sex, only high-resistance PA showed a borderline significant association with lower pain interference (OR = 0.29, 95% CI 0.09–0.98) and a borderline significance association with better ability to participate in social roles (OR = 0.30, 95% CI 0.09–1.02) (online suppl.

Similarly, in analyses of cumulative exposure lagged by 10, 15, or 20 years, adjusted HRs were slightly elevated in the highest cumulative exposure categories but were of only borderline significance (Table 4 ).

However, after Bonferroni correction ( P -value < .0042), the anatomical details and clinical utility showed borderline significance.

Folate and vitamin C showed borderline significance. 3.4.

However, the time after surgery of over five years had a borderline significance (β ​= ​−0.833, OR ​= ​0.435, 95% CI: 0.19–1.00, P ​= ​0.05).

The limitation of using LASSO regression for variable selection is that the shrinkage penalty may exclude predictors with borderline significance, especially when multicollinearity is present.

Indeed, the level of soluble glutathione is lower in all classes of patients (borderline significance for ARDS) compared to controls and the normal reference value (1.4 ± 0.7 mM [ 45 ]).

Interestingly, homozygous mutants of Eya1 have severely impaired calvarial bone development ( Xu et al., 1999 ), and Eya1 was downregulated approximately 50% at E18.5 in the SM (and OFs with borderline significance) of Twist1 +/ − mice and in the OFs of Fgfr2 +/S252W mice compared to WT ( Figure S4 ; Table S1 ).

Potential interaction between APOE4 and LE8 on brain ageing was observed for some age and sex groups but with only borderline significance, further investigation in larger and more targeted studies is needed to validate the finding.

3B–L ) while clonality was not, although it had borderline significance for OS in KIRC (Supplementary Table 7 ).

Second, the findings reveal that children with PA + MPI + OK deficits showed lower accuracy in reading pointed pseudowords only compared with the high group (borderline significance), while not differing from other profiles in this measure.

Gross tumor volume (OR: 1.020, p = 0.052) and lungs V 20 (OR: 3.171, p = 0.067) showed a borderline significance.

Kaplan-Meier survival analysis showed that patients with high serum IL-5, IL-8, PDGF-BB, and VEGF-A showed significantly better survival when treated with sorafenib; moreover, high CXCL9 and TGF-α levels were also associated with better survival with borderline significance (Fig. 3a ).

Although this association was at borderline significance (95% CI: 1.01 – 3.12 and p ‐trend .05), such association did not appear in normal weight individuals (BMI <25 kg/m 2 ).

16 In the study conducted by Opi et al., it was noted by the authors that the opposite concomitant effect of the McC b (rs17047660) allele on the development of severe malaria was of only nominal borderline significance, despite being under significant strong positive selection (iHS<−2.0). 16 At first glance, the association with severe malaria and significant positive McC b selection are discouraging, but this may explain the linkage of negative and protection haplotypes to each other.

After adjustments for age, sex, education and established risk factors, higher concentrations of SELENOP and Se-to-Cu ratio were associated with a lower risk of developing CRC (HR per SD, 95% CI 0.80, 0.71–0.90 and 0.77, 0.65–0.92, respectively), while Free Zn was observed to associate with borderline significance with increased risk of CRC (HR per SD, 95% CI 1.17, 1.00–1.38) (Fig. 2 ).

Borderline significance for this association was observed in the multivariate analysis when controlling for maternal age, CD4 count, and HIV viral load categories (OR 4.88 [95% CI 0.99–24.1] P = 0.05).

There was a slight tendency with borderline significance toward more risky cardiovascular profile in women, i.e. diabetes or Killip class on admission ( Table I ).

[ 53 ] analyzed the MMP-9 rs3918242 variant in MPN patients and found that the CC genotype showed borderline significance in PV patients versus the control group.

A clinical case definition was established using pre-defined thresholds and further refined to include values with borderline significance.

A P value of 0.05 was considered the threshold for borderline significance for inclusion in a subsequent regression model.

Despite a lack of direct comparison with observation, TZDs showed borderline significance when compared with insulin (RR 0.33, 95% CI 0.14–0.78).

This effect had a borderline significance in the obese group.

In the present study, two-week administration of lipid emulsion with an increased amount of n-3 PUFA leads to increased plasmatic level of n-3 PUFA in triacylglycerols, with borderline significance, which could be explained by the minor differences in the n-3:n-6 ratios in applied emulsion.