Barely Significant
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“borderline significance”

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In the literature

In addition, the relatively small sample size, the borderline significance of the primary outcome, the omission of cyclophosphamide on the anthracycline arm, as well as the non uniform assessment of HER2 status and the initial inclusion of a small number of HER2 positive patients are some other potential weaknesses of our study.
26 A long-term analysis of 566 pCR patients from the Gastro-Intestinal Working Group of the Italian Association of Radiation Oncology database found that ACT was even associated with a worse outcome (borderline significance). 27 Therefore, the efficacy of ACT remains controversial in patients who achieve pCR after nCRT. 28 The objective of this study was to assess whether ACT treatment would have any survival outcome benefit in LARC patients who achieved pCR after nCRT treatment and TME surgery.