“borderline significance”

Except for a borderline significance in prostate cancer, there was a consistent association between aspirin use and distant metastasis (M) across colorectal, lung and breast cancers, including the subgroups of colorectal and lung cancers.

While these findings suggest a potential association, their clinical significance remains uncertain; borderline significance may be influenced by multiple testing, which increases the risk of type I errors (false positives).

21% of the included patients in ITS > 3 cm shifted to ITS ≤ 3 cm and showed survival benefits compared to those who remained in ITS > 3 cm with borderline significance.

But to use the medication possession ratio showing statistically borderline significance on development of macrovascular complications, the use of more precise indicator that better reflect medication adherence would lead a more significant result.

In contrast to the expected results, the BMI and type 2 diabetes rates showed borderline significance for being lower in MACS.

Additionally, the borderline significance of the signature in the patients with advanced stage disease, sampled from the independent cohort, might be attributable to the small size of this cohort.

On the contrary, GC 1S/1S genotype was observed to confer risk to Europeans only (with borderline significance).

However, female officers also reported lower levels of work-related social support (borderline significance).

In the ER-negative group, elevated testosterone levels were found associated (borderline significance) with AR-absent expression (OR 2.82, 95% CI, 0.98-8.06).

miR-21-5p was significantly higher expressed in advanced samples in comparison to non-advanced samples and control sera in the Berlin cohort as well as in the cross cohort comparison ( Figure 3 ) and showed a borderline significance in the Wurzburg cohort.

Borderline significance was identified for the interaction between MDM4 rs4245739 * MDM2 rs117039649 on melanoma-specific survival (P interaction 0.14, Table S6 ).

The molecular targeted therapy was statistically associated with better clinical survival (HR 0.271; 95% CI; 0.074-0.992, p =0.049), and WHO functional classification III or IV was associated with poor survival (HR 3.379; 95% CI; 0.874-13.069, p =0.078) with borderline significance.

The difference between correct day orientation on Sundays versus other weekdays disappears as the total MMSE decreases, from statistical significance for total MMSE of above 20 (OR=2.16, 95% CI: 1.45-3.21), to borderline significance for a total score of 11 to 20 (OR=1.45, 95% CI: 0.99-2.13) to none below a total score of 11.

However, as this was based on borderline significance in post hoc univariate analyses with relatively small numbers, the consistency of these findings will need confirmation in other longitudinal studies.

When determining the results of GWAS with P values ranging between 0.05 and 5×10 -8 , statistical approaches other than single standard significance may be beneficial, and we were able to confirm significance in almost half of the genetic variants within this borderline significance range.

In the multivariate model 1, intake of these nutrients remained negatively and significantly associated with %BMD change in hip, except for vitamin K which showed borderline significance.

Multivariate linear regression indicated that only ΔLVEF ( p = 0.046), ΔLAVI ( p = 0.001), and ΔE/e’ ( p = 0.001) remained strongly associated with the changes in adropin levels, whereas ΔBMI ( p = 0.052), ΔLVMMI ( p = 0.052), and ΔNT-proBNP ( p = 0.050) exhibited borderline significance in this matter.

In this small cohort ( n = 24), higher TNM stage and lymph node metastasis, two well‐known risk factors for ESCC, were associated with increased hazard of disease relapse and death with a borderline significance (Figure S14A ), indicating the robustness of the prognostic data.

Consistently, higher levels of choline-containing metabolites have been reported to be associated with poor prognostic features, including tumour grade, proliferation and ER negativity [ 47 ], triple-negativity [ 96 ] and a tumour size larger than 2 cm [ 41 ], as well as higher levels of glycine with larger tumour size [ 41 ] and survival time shorter than 5 years [ 85 ], although the latter did only reach borderline significance.

Downregulation in secondary DLBCL was confirmed by WB analysis at borderline significance.

Other studies found a borderline significance [ 18 ].

Figure 2 shows that hs-TnT and sTNFR-1 remained significantly associated with eGFR decline, while pKIM-1 and hs-TnI demonstrated borderline significance.

None of the differences in the Apgar scores were significant between the two groups, except at 0 min, which showed borderline significance, despite the Apgar scores being higher in the propofol group than in the thiopental group (Table 2 ).

In univariate analyses, age differences reached only borderline significance, with poorer outcomes observed mainly in individuals over 80 years.

This may explain the borderline significance of CVD.