Barely Significant
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“borderline significance”

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In the literature

Finally, based on PFS, we filtered and arranged 29 targets with inclusion criteria: (1) response AUC ≥ 0.6 and PFS ≤ 0.05 in both TR and ET cohorts ( AKT1S1 , NSL1 , ESRRA , TMEM81 , CKB , SGEF ); (2) statistical significance in PFS/OS of two cohorts ( KRT19 ); (3) borderline significance between CR and PD ( SCG5 , CEACAM1 , ALOX12B ) and seven targets with inclusion criteria; (4) statistical significance in PFS of TR or ET cohort.
At the gene level, we identified six (four with borderline significance) susceptibility CS-related genes, including FCN1 , which is expressed in leukocytes and involved in elastin-binding 21 , 22 ; PLAT converts plasminogen into plasmin, crucial in cell migration and tissue remodeling/degradation 23 ; CD46 protects host cells from complement self-cell damage 24 , 25 ; F2RL2 is key in thrombosis 26 ; VTN promotes cell adhesion 27 and inhibits the MAC 28 ; and A2M , which works as a protease inhibitor 29 , 30 .
Nine studies reported that a worse dental status was associated with cognitive decline ([ 22 , 25 , 27 – 29 , 32 , 33 ], one study showed a borderline significance of the association [ 31 ]), three studies reported no significant association [ 24 , 26 , 30 ], and one reported a negative association, i.e., more missing teeth was associated with a lower risk of dementia [ 21 ].