“borderline significance”

At univariable analysis, none of the factors indicated in Figure S1A showed any statistically significant association with PFS, although age > 70 years and receiving more than two prior lines of therapy approached borderline significance.

These were generally taxa with borderline significance in the individual tests from both profiles (i.e., FDR q-values slightly greater than 0.05), where the concordance in associations across profiles resulted in a significant meta-analyzed FDR q-value.

The small sample size limits statistical power and may contribute to borderline significance in some comparisons such as AUC difference.

The p = 0.05 was taken as the borderline significance level. 3.

The test for the effect of neonatal energy intake on relative energy intake shows borderline significance for indirect effect.

While overall differences in other pathways were not statistically significant, several genes showed borderline significance, including ERBB4, ALK, HRAS, RIT1 (RTK/RAS), and CTNNB1 (WNT).

Although this study only demonstrated borderline significance, likely as a result of sample size, the results of these trials mean that combination cisplatin and an antifolate should be the reference regimen in mesothelioma.

There were only borderline significance in the comparison between Southern Hemisphere and the intertropical belt, and no significant differences for the other comparisons 29 .

The largest difference was observed in the QLQ-BN20 headache (5.50; p = 0.06) with borderline significance.

Host time-of-day was not investigated further because Experiment 1 revealed that it did not significantly shape mosquito reproduction or lifespan (host time-of-day only remained in an interaction with borderline significance for blood meal density).

Risk Factors of LH Number Univariate logistic regression models showed the following risk factors of developing five and more LH lesions visible on US: daily insulin dose above 0.7 IU/kg (OR, 3.69; 95% CI, 1.43–10.01), higher total daily insulin dose (OR, 1.05; 95% CI, 1.02–1.09), and higher BMI (OR, 1.14; 95% CI, 1.00–1.31–borderline significance).

Borderline significance was reached and was in accordance with other in situ studies.

Table 2), reaching borderline significance as a predictor of outcomes only for univariate models (S.

A borderline significance was observed for age: young patients (<55 years) were more favorable to be in P4 (24.2%) compared with the elderly (≥75 years) who were allocated in P1 (25.9%) ( p = 0.055).

Although not show significantly different expression in ESCC tissues, the results from PCR assay ( P = 0.073) and TCGA ( P = 0.053) both indicated high expression of miR-18a in ESCC patients with borderline significance.

13 , 29 In our strabismic samples, collagen XII (alpha 1) was increased nearly 4-fold, with strong statistical significance ( Table 1 ), while collagen VI (alpha 3) was increased in one of three sets of experiments with statistical significance, and collagen VI (alpha 2) was increased with borderline significance in that set of experiments ( Supplementary Table S3 ).

Regimen intensity and HCT-CI had borderline significance.

These findings highlight two critical considerations: (1) rigorous multiple testing correction is essential in genetic epidemiology to mitigate false-positive results from extensive subgroup analyses; and (2) observed subgroup associations, particularly those with borderline significance, should be interpreted as hypothesis-generating rather than definitive evidence.

discovered that excessive methylation of the Wrap53 promoter predicts a poor outcome in individuals with borderline significance in a research using tumor and matching non-malignant lung tissue specimens ( 176 ).

Among men this trend was noted in all religious groups though with only borderline significance among Catholics.

However in subgroup analysis, in patients with less than 5 bone metastasis including 160 patients, prostate RT improved OS with borderline significance (HR =0.68, 95% CI: 0.42–1.10).

Of the 1237 polymorphisms representing 22 genes in the IL-6 canonical pathway, 67 additional genes in the IL-6 network, six baseline disease activity end points and two patient populations (all-patient, white), six associations were found to have borderline significance after adjusting for multiple testing, with an FDR of approximately 5%.

However, the history of STIs (aOR: 1.45, 95%CI: 0.99–2.12, p = 0.053) had borderline significance on multivariable analysis (Table 2 ).

Moreover, age- and sex-adjusted Cox-proportional hazard analysis demonstrated the borderline significance in the association between 10 mL/min/1.73m2 higher eGFR, as a continuous variable, and decreased risk of the primary outcome measure.

Additionally, a 6% increase in omission errors was observed, though postnatal NO 2 results showed only borderline significance.