“borderline significance”

Although the sample estimation indicated a lower number of patients (100 patients) than what was effectively studied, our sample of 149 patients generated some associations with borderline significance that could demand more patients.

Given the borderline significance and moderate ROC performance, these findings should be interpreted as exploratory and require confirmation in larger prospective cohorts. hearing-disorders inflammation neutrophil-to-lymphocyte ratio otosclerosis systemic immune-inflammation index The author(s) declared that financial support was not received for this work and/or its publication.

A more advanced age, female sex, larger BMI, greater CCAD, higher leukocyte counts (including total WBC, segmented, and monocyte counts, but not lymphocyte count), and the presence of hypertension and CVD all independently predicted composite endpoint of all-cause mortality and HF admission using a backward stepwise regression analysis (all p < 0.05), with higher fasting sugar showing a borderline significance ( Table 3 ).

In the multivariate analysis borderline significance for age persisted.

Although the lack of heterogeneity ( I 2 = 0%) suggests consistent findings across studies, the result should be interpreted with caution due to the borderline significance and the fact that the confidence interval just touches zero.

Multivariate logistic regression showed that relative changes of LVEF, LA volume index, and early diastolic blood filling to longitudinal strain ratio were strongly associated with the levels of apelin, whereas NT-proBNP exhibited a borderline significance in this matter.

Thrombocytosis was significantly associated with GOLD group D classification in COPDGene and with borderline significance in participants from SPIROMICS.

With respect to the pulmonary function tests, the SUVmax was significantly and inversely correlated with various bronchial obstruction indices, such as the percentage of FEV 1 ( ρ = − 0.562, P = 0.019) and the FEV 1 /FVC ratio ( ρ = − 0.565, P = 0.018); however, the SUVmax was not significantly correlated with the percentage of DLCOc (ρ = − .283, P = 0.348) or FVC ( ρ = − 0.468, P = 0.058), although the latter correlation demonstrated borderline significance.

For heart problems, smoking initiation age before 10 years old remained significantly associated with higher risk in both HRS (aHR = 1.49, 95% CI 1.05–2.11) and CHARLS cohorts (aHR = 1.49, 95% CI 1.05–2.13), while the MHAS cohort showed borderline significance.

Although the p-value for TSH was 0.066 (<0.1), indicating borderline significance, it was also included in the binary logistic regression analysis to avoid omitting any potential independent risk factors.

KKT17 and KKT18 also showed evidence of homology to KKT16, albeit with borderline significance (0.01 < E < 1, figure 3 b ).

The association between global cognition and functional connectivity within the cerebellar network reached significance; however, we consider this to be a coincidence, not reflecting a true effect given the borderline significance and, most importantly, the finding is not reflected in the node-level analyses where global cognition is barely associated with the cerebellum.

31 Despite the lack of any significant differences at baseline, Janson et al 15 in their RCT accentuated improved EORTC QLQ-C30–measured social function (borderline significance) at 12 weeks for patients who underwent laparoscopic colectomy compared with patients after open resection.

While Blacks are also more likely to have poorly controlled disease this only attains borderline significance.

For "no sport" in the adjusted model, the risk was higher only for females in the French speaking part (borderline significance).

For comment #6, we think that many things about the borderline inter-group difference of the composite neurologic outcome composed of stroke and delirium, have already been covered in the Discussion section, including an acknowledgement of the borderline significance, a brief introduction of recent relevant publications, and the necessity for additional studies to elucidate this correlation.

Also, patients from the ERA group had higher ANA positivity (94% vs 68%; P = 0.075), ANA titer [1280 (1000; 2560) vs 320 (0; 5120); P = 0.077]; lower C3 [0.57 (0.4; 0.8) g/L vs 0.85 (0.7; 1.1) g/L; P = 0.059]; and C4 fractions of complements [0.10 (0.06; 0.14) g/L vs 0.19 (0.10; 0.24) g/L; P = 0.075] with borderline significance.

The reduced sperm count in triple punch biopsy group compared to control group reviled borderline significance, while in single punch biopsy compared to control group no significant difference was found which indicates less harmful single according to a triple needle biopsy.

However, it is worth mentioning that in model 3 (i.e., after adding authoritativeness), PYSRC became statistically significant, (AOR = 1.02, 95% CI: 1.001, 1.042, p = 0.044)], but the borderline significance did not hold in model 4 when the interaction term was added ( Table 2 ).

Only a few of the associations survive at borderline significance when adjusted for birth weight ( Figure 4 B & Supplementary Table 11 ), thus the association of HIF3A methylation with later weights may reflect the growth trajectory set at birth.

The second factor that that showed a borderline significance with the risk of death was the symptom of weakness in a leg.

DCBs demonstrated comparable MACE incidence to DES and a numerically lower risk compared with noncoated devices, with the interaction between comparator type and treatment effect reaching borderline significance ( p for interaction = 0.0513).

The MRRs significantly increased for CVD and RD, and slightly increased with borderline significance for cancer among men (MRR 1.53; 95% CI, 1.28–1.83, MRR 1.37; 95% CI, 1.08–1.74, and MRR 1.16; 95% CI, 0.99–1.36, respectively), but not among women, with borderline significance for sex interaction ( P -interaction = 0.077, 0.074, and 0.044, respectively).

Supporting information Figure S1 Correlations between DTI measures and clinical scores which showed borderline significance.

[ 29 ] found that the 10-year survival rate was significantly higher in patients who were HBsAg-negative (82.8%) compared to those who were HBsAg-positive (51.4%) ( p < 0.005), but their multivariate analysis revealed results comparable to ours, with HBV status showing no or only borderline significance in the modern era of antiviral therapy.