Consistent with recent GWAS results indicating independent genetic contributions to susceptibility and prognosis in Crohn's disease 18 , no PRS approached significance for disease progression, which further highlights the enhanced resolution provided by TRS.
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“approached significance”
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The difference between BN and AN groups (Z = 2.46, p = 0.082, 95% CI [-0.01, 0.22]), approached significance.
In the current study, the number of cases was small and none of the odds ratios approached significance.
Furthermore, the tail of the left caudate nucleus (−18 −46 13) showed a main effect of GLA (F(1, 19) = 3.914, p = 0.028) and the interaction of lexical status with GLA (F(2, 38) = 2.940, p = 0.065) approached significance.
We also observed downregulation of two genes associated with oligodendrocytes, including Enpp2 (see Tables S2 and S3 ) and Mbp (see Table S3 in Supplementary Material), and a third gene Nkx6-2 approached significance for the B6 mice only ( Q = 0.016; data not shown).
In the GSE87304 cohort, only the low expression of MMP10 (HR = 0.607 (0.35–1.05), p = 0.0683) approached significance for improved recurrence-free survival ( Supplemental Figure S2A ).
On contrary, RS decreased the proportion of primary BAs in faeces, and its effect on increasing the LCA/(LCA+CDCA) ratio approached significance.
At year 2, change in binge drinking ( p = .048) was the only predictor that was selected, while total calories ( p = .07) and breakfast consumption ( p = .059) approached significance.
NC 6 approached significance (Table 1 ; mean = 0.22, sem = 0.13), indicating that these conditions showed a small bias for being judged as moving.
Gender, boys compared to girls, approached significance but fell outside of the critical region.
While the direct effect of cognitive ability at T1 on grades remained significant, neither the regression from cognitive ability on epistemic behavior nor the regression from epistemic behavior on grades and, subsequently, the indirect effect approached significance.
The peak amplitude of the ASR in the adults displayed an overall effect of prenatal dose of cocaine [ F (3,80) = 6.0, p ≤ 0.001], but neither of sex of the offspring nor the interaction of dose and sex approached significance ( p s > 0.10).
Clinicopathological parameters stage and hematogenous metastases, genes SUCLG2P2 and SUCLG2 approached significance on univariate analysis but were not predictive of survival on multivariate analysis.
PPI was significantly correlated with gene expression for one of two probesets in Cap2 (r = −0.6, p-value = 0.039) and approached significance using at least one probeset in Dtnbp1 (p-value 0.1) and Tsn (p-value 0.085).
Higher educational attainment among mothers was associated with greater involvement in active housework by spouses, and the association between mothers working full-time and spouses’ active housework also approached significance.
Nevertheless, the time × genotype interaction approached significance, and when one-way ANOVA was performed on the percentage of freezing during the first, second, and third 1-min time periods separately, while no significant genotype effect was detected in the first minute, F(3, 53) = 2.47, p = 0.0720, or the second minute, F(3, 53) = 1.34, p = 0.2712, there was a significant genotype effect in the third minute, F(3, 53) = 3.25, p < 0.05.
The Block × Stimulus (F 2, 40 =2.75, P =0.076) and Rat Strain × Stimulus (F 1, 20 =3.16, P =0.091) interactions approached significance.
UD group comparison of the mean scores on each of the eight defined subscales of the Therapist Response/Countertransference Questionnaire, one subscale differed significantly and one approached significance.
The only climate factor related to BCS was a positive relationship with humidity, although the effect of rainfall approached significance.
In fact, although our results only approached significance, adolescents in our sample had slightly higher accuracy in the omission condition.
While well-ventilated houses had similar indoor mosquito densities to poorly ventilated ones in the absences of house screening, there was an interactive effect between the two factors that approached significance for Cx. quinquefasciatus and was highly significant for An. arabiensis (Table 3 ).
Prenatal tobacco smoke exposure also approached significance in correlating with child Hg levels, hinting at combined toxicological stresses on neurodevelopment [6] , [13] .
Pre-shift specific gravity became significant in this model and post-shift specific gravity approached significance (OR 1.21, 95% CI 1.00–1.46 and OR 1.20, 95% CI 0.98–1.47).
The difference for sex (change in OR = 0.41, 95% CI = -0.05, 0.86, p = 0.65) and “Canada all my life” (change in OR = 0.77, 95% CI = -0.14, 1.80, p = 0.074) approached significance.
Furthermore, those treated early showed a decrease in HAQ DI scores from baseline to year 10, which approached significance, while those treated later had increased HAQ DI scores at year 10 compared with baseline, again after adjustment for differences in disease severity between groups 30 .