Barely Significant
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“approached significance”

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approached significancep = 0.0891.8× alpha
Neural Response and Stimulus to Response Consistencies The Mann−Whitney test results revealed no significant difference between the two groups for neural response consistency, but the odd/even condition approached significance, where the experimental group had lower neural response consistency than the control group (U = 27.00, z = −1.739, p = 0.089, r = −0.39) ( Figure 2 ).
approached significancep = 0.0891.8× alpha
While the decreases observed in the different CYP2C19 metabolizing groups were not significant ( p trend = 0.26), the difference approached significance ( p = 0.089) when comparing the combined UM 2C19 + EM 2C19 groups (11.9 ± 6.4 pmol•min −1 •mg −1 microsomal protein) versus the combined IM 2C19 + PM 2C19 groups (10.1 ± 5.3 pmol•min −1 •mg −1 microsomal protein; Fig. 4B ).
approached significanceP = 0.0891.8× alpha
In patients with a mixed episode at baseline, LS mean ± SE changes in CGI-BP-D severity score with asenapine were significantly greater than placebo on day 7 (-0.7 ± 0.1 vs -0.3 ± 0.1; P = 0.008) and approached significance on day 21 (-1.0 ± 0.1 vs -0.7 ± 0.2; P = 0.089); asenapine and olanzapine did not differ on either day 7 ( P = 0.968) or 21 ( P = 0.543).
approached significancep = 0.0901.8× alpha
Repeated-measures ANOVA showed a significant main effect of probability ( F 4,620 = 262, p < 0.001) with an interaction between probability and group that only approached significance ( F 4,620 = 1.98, p = 0.090); no other pair-wise comparisons or ANOVA effects were significant.
approached significanceP = 0.091.8× alpha
Before fixing the cut-off, we examined alternative thresholds (20%, 25%, 30%, 50%) in sensitivity analyses: at 20% the OS difference within the high Ki-67 stratum was non-significant ( P = 0.19), approached significance at 25% ( P = 0.09), became significant at 30% ( P = 0.001), and was more pronounced at 50% ( P < 0.001), at the cost of excluding patients with Ki-67 between 30 and 50% who may still benefit from ICI-chemo.