“a weak trend”

Strength training and impact activities (like walking or running) can help to offset the decline of bone mineral density and prevent osteoporosis.[ 12 ] It also reduces low back pain.[ 13 ] It is proven to help reduce stress and improve the mood.[ 14 ] It may help to reduce hot flashes, thereby minimizing the “Domino effect.” Although no conclusive evidence was derived from randomized controlled trials on whether exercise is an effective treatment for reducing hot flushes and night sweats in menopausal women, the latest Cochrane review did find a weak trend for exercise to be more effective than no intervention.[ 15 ] GETTING STARTED It is never too late to start exercising.

The posterior mean probability of selecting reduce was similar across HFI levels, with a slight tendency toward lower probabilities at large HFI levels (small: 0.14 [95% credible interval 0.00 to 0.82]; medium: 0.14 [0.00 to 0.83]; large: 0.10 [0.00 to 0.64]), but the credible intervals suggest this was a weak trend (Appendix S4 ; Figure 3 ).

This is supported by the observation of only a weak trend in methylation changes at these CpGs towards a younger methylome (Fig. 4 C) and aligns with previous findings that CpGs with a greater impact on healthy longevity do not necessarily undergo substantial methylation changes during aging [ 114 ].

There was a weak trend toward a decrease in body weight of −0.07 kg/week ( r = 0.1949).

A recent phase 2 clinical study in patients with nonalcoholic steatohepatitis (NASH) and stage F2 or F3 fibrosis found that 52 weeks of tirzepatide administration significantly improved the resolution of NASH without worsening fibrosis, but had only a weak trend toward fibrosis regression ( Loomba et al., 2024a ).

36 However, when the temperature was raised to 50 °C, the acid leaching efficiency of HCl and HAc solution was reduced to 68.73% and 29.83%, and at the temperature of 60 °C, the leaching efficiency of HCl and HAc solution was similar to that at 50 °C and also had a weak trend of decline.

A weak trend in the same direction was observed between the time spent looking at the target and localisation error although this did not reach statistical significance ( p = 0.128).

In the initial publication, only a weak trend was observed between the antitumor activity of loncastuximab tesirine and CD19 expression levels across ten cell lines, including CD19-negative cells. 11 Here, we expanded the number of cell lines analyzed and, even when focusing only on B-cell lymphoma models, we observed a significant correlation

Outcome events In both placebo- and empagliflozin-treated patients, patients with prHT were generally at increased risk for all outcomes compared with patients with no-prHT—with the only exception of all-cause mortality in the placebo group which only showed a weak trend in this respect (heart rate 1.13, 95% confidence interval, 0.82–1.56 for prHT vs. no-prHT).

The “Overall Safety Score” and “Patient Safety Rating/Unit Grade’ exhibited a weak trend with a negative effect size, suggesting a gradual decline in the perception of safety over the studied period.

Table 1 shows that only 2 out of 12 variables correlated with Ca 2+ -spike in terms of coactivated spine numbers, whereas both D-spike and global Na + -spike initiation threshold spine numbers did not correlate significantly with any tested variable, with a weak trend for a positive correlation between spine distribution and global Na + -spike initiation ( Fig 8C ).

There was a weak trend of men having a shorter intersurgical interval, but after controlling for the far stronger, and statistically significant, variables of country and time since diagnosis with multiple linear regression, there was no association with gender.

However, the dose–response patterns were inconsistent, although a weak trend could be seen for grain dust and fungal spore exposure.

Although intergranular tensile cracks were dominant in all the samples, a weak trend can be observed where the percentage of intragranular cracks increases in coarse-grained samples.

Consistent with these findings, we also observed a weak trend for a decline in FA in the hippocampal cingulum bundle, a key component of the limbic system involved in communication with the hippocampus.

Although it was not statistically significant, it had a weak trend that the known risk factors be positive predictors to future exacerbation in our result.

In particular, the PV+ population did not undergo the robust between-session increase in surround suppression and reduction in preferred stimulus size observed in excitatory neurons, although it did exhibit a weak trend in this direction.

However, in the natural environment, only a weak trend was obtained for static conditions (standing with a bike) and there was no correlation for dynamic conditions (during riding).

DNMT1 copy number showed a weak trend for association with sensitivity to PI-103 and THZ-2-102-1, whoever it did not reach the threshold of | ρ | > 0.3 ( ρ = − 0.256 and − 0.268, respectively; Additional file 7 : Table S4).

Under the same circumstances, the NMMO selectivity showed a weak trend of continuously decreasing.

Although the sample size for each year was small, the number of years since the training period was not a significant predictor of the strength of response, but there was a weak trend towards a decrease in strength of response to playbacks conducted two or more years after the training period versus those conducted earlier (Fig. 4 , Table 5 ).

There was no correlation between methylation levels of the TNF gene and any demographic or clinical variables, with the exception of age, which showed a weak trend for reduced methylation with age (rho = −0.440).

There was a weak trend to increase in the absolute number of CD4 T cells in the group receiving 0.25 mg of the studied vaccine, but the differences with the placebo group were not statistically significant. 4.

Second, there was a weak trend indicating that higher symptom severity at admission, as measured by the HoNOS score, might be associated with increased dropout risk (OR 1.07, 95% CI 0.99-1.15; P =.08), though this finding did not reach statistical significance ( Table 3 ).

However, this association was not detectable when the data on ARI incidence in the first 6 months of life were excluded, with only a weak trend present in univariate but not multivariate analysis.