However, Kaplan-Meier analysis showed that higher JARID2 expression was not significantly associated with overall survival (OS) in either fusion gene positive RMS (p=0.386, n=39) or fusion gene negative RMS (p=0.089, n=81), although the latter may be considered a trend towards significance.
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“a trend towards significance”
In the literature
The association between stable SMM and improved physical functioning showed a trend towards significance [9.2 points (95% CI: −0.1 to 18.6)].
Table 2 shows the results of the logistic regression model fitted to the variables that were statistically significant or at least showed a trend towards significance in the bivariate analysis with results of suicide acts, which either led to death or not.
There was also a trend towards significance for the internal factor of ‘skills or ability to care, which indicates a sense of personal competence and fulfilment in providing care, and higher care‐related quality of life.
A p -value below 0.05 was considered statistically significant, and a value between 0.05 and 0.10 was considered a trend towards significance.
A larger study involving several causative drugs found a trend towards significance for the class I serotype HLA‐A11 in DILI associated with tricyclic antidepressants and diclofenac and for the class II serotype HLA‐DR6 with DILI due to chlorpromazine [ 22 ].
There was a significant increase in the level of Arc mRNA expression analyzed by radioactive in situ hybridization in the OFC of EXP animals compared to the CC group, and a trend towards significance in PRL.
Several areas showed a trend towards significance, which may have been more marked given a larger sample size.
6 Conclusions This study demonstrates that PNP during CB-A is associated with a lower success rate, higher risk of AT/AF recurrence after CB-A and a trend towards significance for RF touch-up to complete PVI.
Regarding the duration of the training sessions, it is concluded that there were no significant differences between the control group and the experimental group between both study phases, but there was a trend towards significance in the experimental group, where the duration of training was increased.
Prior to this study, no single ICD trial enrolling NICM patients has shown a statistically significant reduction in mortality, although there was a trend towards significance in the DEFINITE and SCD-HEFT trials. 7 , 15 In both studies, the percentages of patients on optimal pharmacological therapies were lower, and no patients received CRT, including those patients with a wide QRS for whom CRT would be indicated.
Those patients with early readmission were also older (79 ± 6 vs 73 ± 13 years old) with a trend towards significance (p 0.07).
To reduce the complexity of the methodological approach, further analysis was limited to a series of 10 genes (GSTP1, HIC1, RASSF1-locus2, CD44,DAPK, RASSF1-locus1, TP73, BRCA1, ESR1, TIMP3) that proved significant or showed a trend towards significance ( P values varying from 0.02 to 0.31).
However, with Bonferroni corrections (p value of .05/10 = .005) none of the comparisons reached significance (all P ’s > .005), although there was a trend towards significance for the body straight/head congruent condition (Mean = 316.2; SD = 48.1) to be faster than the body straight/head straight condition (Mean = 321.6; SD = 47.0), t (45) = 2.79, P = .008.
A further study found no associations in men, but a trend towards significance across categories of the DASH score in women [ 64 ].
Factors found to be significant in a multivariate analysis of patient- and physician-level factors include male patient gender, patient age, hypertension, and history of coronary artery disease, with greater physician experience demonstrating a trend towards significance (OR 1.85, p 0.095, 95% CI [0.09 – 3.81]) ( Table 4 ).
Use of recreational drug in the past year was associated with CMV seropositivity in univariate analysis and showed a trend towards significance in multivariate analysis.
However, there was a trend towards significance with four years of gluten-free diet ( Table 2 ).
In addition, in the study by Barlo et al., the rs2637988 G allele was significantly associated with IPF susceptibility (OR = 1.95) whereas rs408392 showed only a trend towards significance (Barlo et al. 2011 ).
Simple Pearson correlation analyses indicated a significant relationship or a trend towards significance of 25(OH)D with several vascular outcomes, but not seated BP or supine DBP ( Table 3 ).
The CRP/albumin ratio showed a trend towards significance.
Although there was a trend towards significance in the frequency of Th1 and Th17 cells in HKTC-immunized mice relative to control mice, this increase was not significant, and there was also no significant increase in Th2 responses, despite the detection of significant levels of IFN-γ + and IL-4 + antigen-specific bulk splenocytes in mice immunized with HKTC.
27 30 Computerised testing of the whole SRC cohort revealed a trend towards significance of SRC-associated decrease in motor speed, psychomotor speed and reaction time.
4 Moreover, self‐expandable valves, which here presented a trend towards significance in increasing periprocedural CVE occurrence, have not always been associated with increased stroke incidence after TAVR. 5 Finally, both recent improvements in device technology and increasing operator experience over time have been associated with lower peri‐procedural stroke rates in most but not all studies. 2 , 3 This may be related to the different implantation techniques adopted (eg. use of a periprocedural balloon, device repositioning, etc.) as well as clinical differences among the studied populations (e.g., carotid disease, atrial fibrillation, etc.).
Four other variants, extracted from the GENIE study, showed a trend towards significance, (rs191101580, rs187087030, rs8060932, rs8062123), and rs8060932 is in LD with another SNP (rs4238595) associated with FJHN [ 21 ].