No significant differences in the firing rate between groups after FDR correction for multiple comparisons were found, although DEX and REMI, and REMI in combination with CLONI showed a trend towards significance ( t (209) = 2.64, p = 0.0531; t (269) = 2.28, p = 0.0695).
Similarly, table 3 shows that patients without diabetes and admission BG >180 mg/dL had increased mortality, intubation, ICU admission, and AKI, while those with diabetes and admission BG >180 had increased mortality, ICU admission, and a trend towards significance for intubation (p=0.0534) Table 4 shows the adjusted ORs for the main outcomes according to BG levels in the diabetes and non-diabetes cohorts.
When adjustments were made for confounding differences, females had a statistically significant greater improvement in the their WOMAC function ( p = 0.03) and total ( p = 0.03) scores compared to males, but these improvements were not clinically significant (Table 3 ). A higher rate of overall satisfaction was observed in male patients, with a trend towards significance ( p = 0.054) for female patients to be less likely to be satisfied (Table 4 ).
However, the bootstrap regression model showed only a trend towards significance for the time estimation task in predicting consistency on head trials (β = −0.259, t = −2.291, p = 0.054).
Gender is a factor differentiating SRT in favour of men [ 12 , 13 , 14 ], but the results of this study indicate no significant differences in SRT for all observed conditions, apart from a trend towards significance during cycling (boys revealed shorter SRTs than girls, p = 0.054).
3.2 Structural results 3.2.1 Gray matter The multiple ANCOVA revealed hypertrophy of the left caudate nucleus in the long disease duration group ( p = 0.012, FDR-corrected) and a trend towards significance of the right caudate ( p = 0.054, FDR-corrected) ( Fig. 2 ).
Significant within-group increases occurred in ED (P≤0.001, g=1.75) and CT (P=0.001, g=1.02), with a trend towards significance in C (P=0.054, g=0.53).
Luminescence readings in the lungs on Study Day 12 were significantly ( p ≤ 0.05, Dunnett’s multiple comparison test) lower in the group treated with mIL2-mIL12 and the TK-mIL2-mIL12 groups compared with the vehicle control and there was a trend towards significance for the group of mice treated with PEG-mIL12 ( p ≤ 0.054, Dunnett’s multiple comparison test) (Fig. 5 B).
Among women, high-risk versus moderate-risk categories had log-rank P=0.008, with a trend towards significance for that comparison in men (P=0.054 for high-risk vs moderate-risk categories).
TBI showed a trend towards significance (OR; 0.132, 95% CI: 0.016–1.071, p = 0.054).
After multivariate analysis, a trend towards significance was also observed ( p = 0.054).
Using anti-glare filters also showed a trend towards significance (p = 0.054), suggesting that they may help reduce CVS symptoms.
Cox proportional hazards regression analysis considering only tumour region volumes provided an almost significant model: − 2 log-likelihood = 146.066, χ 2 (4) = 9.303, and p = .054 with a trend towards significance of the hazard function: p = .067 and HR = 1.077 for the non-enhancing tumour volume.
However, HF-fed mice exhibited significantly lower expression levels of PPARγ in gWAT ( p < 0.01) and in PAT ( p < 0.05), and a trend towards significance in iBAT ( p = 0.054), compared to their chow fed-counterparts ( Supplementary Figure S2B ).
Revascularisations utilising percutaneous transluminal angioplasty (PTA) were performed in 34 (36 %) of no contact patients and 6 contact (19 %) patients with a trend towards significance ( p = 0.054).
By contrast, treatment with kidney transplantation was associated with a statistically significant improvement in the Auditory Verbal Learning Test (AVLT-T5, percent change = 20.9 %, p = 0.003), the AVLT learning score (percent change = 35.9 %, p = 0.009), the AVLT immediate recall (AVLT-IR, percent change = 31.9 %, p = 0.002), and the AVLT delayed recall (AVLT-DR, percent change = 23.3 %, p = 0.012), as well as a trend towards significance in the Digit Symbol test (percent change = 12.2 %, p = 0.054).
Notably, only short-term SD was associated with increased anxiety levels in these animals, as indicated by a trend towards significance [short-term SD: P = 0.054, SMD (95% CI): −0.24 (−0.47, 0.00); long-term SD: P = 0.829, SMD (95% CI): −0.04 (−0.42, 0.34), as illustrated in Fig. 6A ].
We note that the mean difference between these groups on the interference measure (test 3–test 2) of the Stroop test showed a trend towards significance (incomplete follow up M = −0.35 vs. complete follow up M = 0.07, p = 0.054). 3.3.
Assisted enteral feeding was associated with increased odds of a positive outcome in dogs with inflammatory PLE (OR 3.2, 95% CI 1.0‐10.5), with a trend towards significance (P = 0.054).
In contrast, the percentage of patients in the TG with significant anxiety (cut-off >8) significantly changed over time (p = 0.035) while in the CG a trend towards significance was found (p = 0.054).
A trend towards significance was observed ( P = 0.054).
Vesicoureteral reflux grade showed a trend towards significance (β = 0.545, p = 0.054), but dexamethasone treatment showed no effect.
After incorporating an ANCOVA and accounting for the covariate disease duration, the left superior frontal cortex remained associated with changes in postoperative motor function ( p = 0.005), while there was a trend towards significance for the cluster in the right superior frontal cortex ( p = 0.054; c.f.
Using Cox proportional hazards regression, a trend towards significance (P = 0.054) was found for the model consisting of the three variables with the lowest P values in univariate analysis: stage, diabetes mellitus status and postoperative complications.
We found an association between high PAI-1 and uPAR-del4/5 mRNA expression levels and an increased risk of tumor-related death for R0 patients using multivariate Cox regression analysis with relative risks (RR) of 6.55 (95%CI = 1.0-44.5) and 6.00 (95%CI = 0.8-47.1), respectively, with a trend towards significance ( P = 0.054 and P = 0.088, respectively; Table 3 ).