Barely Significant
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“a trend toward significance”

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In the literature

Gonzalez-D'Gregorio et al found a trend toward significance regarding mortality for patients with ID during a median follow-up of 5 years while Zeller et al reported ID as a predictor of MACE defined as myocardial infarction and CV mortality during a mean follow-up of 4 years. 21 , 22 Finally, we analyzed the role of different factors in patients' prognosis.
33 In addition to examining the effects of CYP3A4 on surrogate markers, an observational case-control study involving 186 patients receiving clopidogrel for ACS found only a trend toward significance of an association between the presence of a CYP3A4 polymorphism and the occurrence of a repeat cardiovascular event while receiving clopidogrel (16.8% vs 9.6%, P = 0.052). 34 CYP3A5 A multivariate analysis of 348 patients treated with clopidogrel after planned stent placement investigated the effect of a CYP3A5 polymorphism on the risk of atherothrombotic events at one and six months post-procedure. 35 The study identified CYP3A5 polymorphisms as an independent predictor of atherothrombotic events at six months follow-up.
Moreover, according to the results of logistic regression analyses, putative PIU was positively predicted by OBS-SV Doubt domain (and Childhood and Adolescence appendix only with a trend toward significance), as well as by AdAS Spectrum Non-verbal communication domain.
The ideal dosing remains unclear, but in 1 study, there was a significant improvement in the oxygenation index at 30 ng/kg/min, and a trend toward significance at doses of 20, 40, and 50 ng/kg/min (LoE B). 68 , 69 Iloprost It is a prostacyclin analog pharmacologically similar to epoprostenol, with a longer half-life (20-30 minutes), lower viscosity, greater stability, and more physiologic pH, turning it a better choice for nebulization.
Inhaled Pharmacotherapy for Neonates: A Narrative Review.
Turk Arch Pediatr · 2022 · PMC8867519