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“a trend toward significance”

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a trend toward significancep- value = 0.0881.8× alpha
We observed a risk effect when two or three rare alleles were present at both loci , rs17793678 C/T and rs1510521 G/-, OR = 1.41 (95% CI 1.12–1.78) p- value = 0.004, and when three or four rare alleles, rs17793678 T/T and rs1510521 G/- were present, we obtained an OR = 1.54 (95% CI 0.96–2.48) with a trend toward significance (p- value = 0.088).
a trend toward significancep =0.0881.8× alpha
Similar results were found for VMAT-2 inhibitors as a class pertaining to response defined according to CGI criteria (k=9; RR =1.50; 95% CI =1.14, 1.97; p =0.003; I 2 =44.32%; NNT =6, 95% CI =3, 18, p =0.004), with consistent results for valbenazine (k=5; RR =2.06, 95% CI =1.24, 3.41; p =0.005; I 2 =59.96%; NNT =5, 95% CI =3, 62, p =0.034), while deutetrabenazine showed only a trend toward significance (k=4; RR =1.32; 95% CI =0.96,1.82; p =0.088; I 2 =0%; NNT =9, 95% CI =4, 200, p =0.041).