Barely Significant
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“a trend toward significance”

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In the literature

No significant difference, but a trend toward significance, was observed between groups regarding the number of responders at the end point (>50% decrease from the baseline), one month after the stimulation sessions (1/18 in the sham group versus 6/21 in the active group; p = 0.098); there was only one responder in the active group at day 5 (the one also achieving remission criteria). 4.
118 , 119 In a Phase II study in patients with predominantly negative symptoms, the addition of bitopertin 10 mg or 30 mg once daily to a stable regimen of antipsychotic therapy significantly improved the PANSS-NSFS after 8 weeks of treatment (per protocol population) with a trend toward significance in the ITT (intent-to-treat) population. 80 The SearchLyte Phase III program studying adjunctive bitopertin for the treatment of symptoms of schizophrenia is composed of six trials; three in patients with predominant negative symptoms ( NCT01192906 , 120 NCT01192880 , 121 NCT01192867 122 ) and three in patients with suboptimally controlled symptoms ( NCT01235559 , 123 NCT01235585 , 124 NCT01235520 125 ).
Three of six analyzed genes ( Cyp1a , Cyp3a11 and Cyp3a41 ) had significantly decreased or increased expression levels in R6/2 mice compared to WT littermates, whereas both Cyp2b9 ( p = 0.0709) and Cyp2a4 ( p = 0.0975) genes showed a trend toward significance between R6/2 mice and WT controls ( Figure 1 C).