Barely Significant
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“a trend toward significance”

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In the literature

p Values of the mediating path “intervention–bacteria–CMFs” less than 0.05 were considered significant to identify precise and robust results, meanwhile p values for the mediating path “microbiota–metabolites–CMFs” less than 0.1 were considered a trend toward significance to uncover more insightful findings.
The decrease in the left lateral temporal cortex (p = 0.08, from 0.127 to 0.067) showed a trend toward significance, but did not reach statistical significance, while changes in the right lateral temporal cortex (p = 0.74) and left entorhinal cortex (p = 0.29) were not statistically significant.
In the fully adjusted regression model, HAM-A showed the numerically largest standardized coefficient (β = −0.055; p = 0.064), representing a trend toward significance, while HDRS-17 did not individually reach statistical significance (β = −0.043; p = 0.147); cognitive impairment had negligible independent effects (β = −0.001; p = 0.947).