When we plotted the aspect ratio against granule size (the 2‐D area occupied by the granule in the image) for all granules imaged per line, we saw a strong trend that granules became less circular (i.e., had decreased aspect ratios) as their size increased in the control and MRC‐OE lines (Figure 5e,g ).
There was a strong trend for a negative correlation between the score and LA.
Primary use of argatroban also showed a strong trend toward more PRBC transfusion.
The increase in activity with 5 μM of FKBP12 was less than with 0.2 or 1.0 μM of FKBP12, and there was a strong trend toward reduced activation with 1.0 and 5 μM of FKBP12 compared with 5 nM and 0.2 μM of FKBP12.
The primary outcome of all‐cause mortality or intervention due to HF decompensation was not significantly different between the two groups, although it showed a strong trend in favour of aCRT [hazard ratio (HR): 0.89, 95% CI 0.78–1.01].
There was also a significant main effect of treatment group on proximity to the platform with Tukey post-hoc tests revealing a strong trend for an impairment in the Tg-control group relative to the WT-control group, and a significant enhancement of performance back to WT levels for the Tg-sAPPα group, compared to the Tg-control group (Fig. 2c, d ).
Panels (b) and (c) in Figure 4 indicate that even though the yearly posterior medians are different, we should not interpret a strong trend from these data.
While the PARAGON 58) trial demonstrated a strong trend towards significance for its primary efficacy endpoint, there was a more encouraging signal with regards improvements in quality of life, symptoms and reduced hospitalisations for HFpEF patients.
35 , 36 Moreover, a recent meta‐analysis showed that the combination of drugs used in our study to define OMT provided a strong trend for the reduction of all‐cause death and HF hospitalization. 37 Because our study aimed to reflect real‐world clinical practice, we believe that our results depict the usual clinical approach, even though this remains a limitation and our conclusions about OMT use in HFpEF and HFmrEF must be taken with caution.
In line with previous research, age at the time of breast cancer diagnosis was found to show a strong trend for predicting emotional vulnerability in women, with a younger age inferring higher levels of emotional vulnerability.
At the same time, there is a strong trend in preclinical research towards repurposing natural compounds for scientific and medical purposes as de novo drug discovery and drug synthesis is both time-consuming and expensive.
Also there was a strong trend toward knockdown of BMP-6 leading to an increase in BMP-2 mRNA in osteoblasts.
While this is still lower than is observed for the main coding region AUGs, it is a strong trend and one not observed in the downstream controls, where conserved ORFs have no noticeable enrichment for optimal AUG context.
After controlling for the common set of confounders, a strong trend of elevated risk with higher parity was observed, relative to 1–2 children, with odds ratios of 1.25 (95% CI: 1.07–1.46) for women reporting three or more children Table 2 .
57 We observe a strong trend toward decreased STP in adult KIBRA cKO mice with no change in charge transfer during TBS induction, consistent with depleted pools of extrasynaptic surface AMPARs under basal conditions in these mice.
In multiple logistic regression analysis (Table 3 , last two columns), when the potential confounding was adjusted for and the clustering by hospital was taken into account, the independent roles of gender (OR = 0.72; 95%CI = 0.64-0.84 when comparing females to males), age (a strong trend over the whole age range, with OR = 0.35; 95%CI = 0.25-0.48 when comparing 85+ to up to 50 yrs.) and illness severity (OR = 0.48; 95%CI = 0.37-0.61 when comparing Charlson index 3+ to 0) were confirmed, while low SES level emerged as an independent determinant of non-admission to CCU (OR = 0.79; 95%CI = 0.65-0.95 and OR = 0.81; 95%CI = 0.66-0.99 when comparing levels III and IV, respectively, to level I, area under the ROC = 0.704; H-L = 15.1, p = 0.06).
Introduction Development of point-of-care (POC) diagnostic medical devices has been a strong trend in recent years.
Although not statistically significant, after 3 weeks of exposure with the low dose of I-BET-151 (2 mg/kg/day), there was a strong trend towards less severe mitochondrial injury as compared to the higher dose, both in the right ( Figure 1 C,c and Table 1 ) and in the left ( Figure 1 I,i and Table 1 ) ventricles.
Effects of pentoxifylline on serum cytokines As pointed out above, the serum cytokine levels presented in Table 2 , demonstrate that patients treated with PTX showed a strong trend toward an increase in IL-10, an anti-inflammatory cytokine, suggesting a favorable effect of the drug in modulating the inflammatory mechanisms present in the chronic phase of the disease.
Gordon Brown’s relatively short period of power was marked by stasis on one of the indicators and decline on the other two, and stasis was the main characteristic of the first years of the coalition government led by David Cameron. From the mid-1990 s on there was a strong trend in British attitudes away from a pro-welfare stance and towards a neo-liberal, ‘workfare not welfare’, position, therefore.
A strong trend towards a higher rate of differential expression for genes with longer transcripts is evident.
While RT-qPCR analysis of regenerative markers within the terminal ileum yielded no significant differences between irradiated Adam17 fl/fl ;Defa6-cre + /− mice, we did see a strong trend towards decreased Nox1 expression in Adam17 fl/fl ;Defa6-cre + mice (Fig. 7F ).
Although the p-value for experienced readers did not reach the conventional threshold of significance in McNemar's test (p = 0.0604), a strong trend was observed, and significant improvement was found for less experienced readers (p = 0.00173).
When we analyzed the immunosuppressive T cell populations, although FOXP3 + CD4 + cells were not different between the two groups, exhausted T cells (PD1 + CD8 + ) cells showed a strong trend towards being able to discriminate Group 1 from Group 2, Group 2 having a higher percentage of PD1 positive CD8 + T cells (Supplementary Fig. 10d–f).
A strong trend between baseline glucocorticoid dosage categories (none, <7.5, or ≥7.5 mg/day) and each yearly time point was not identified.