“a strong trend”

The main finding of this study is a significant genotype effect on TOL (F = 6.902, p = 0.009) and FFDI performances (F = 7.125, p = 0.008) as well as a strong trend on SOPT error scores (F = 4,996 p = 0.026) and Digit Span performance (F = 6.28, p = 0.023).

Moreover, there was a strong trend toward improved OS in favor of the retifanlimab arm (median OS: 29.2 months vs. 23.0 months; HR 0.70; 95% CI 0.49–1.01; p = 0.0273), although survival data were immature at data cutoff [ 43 ].

Trial Duration Meta-regression revealed a strong trend towards shorter duration trials demonstrating a greater efficacy of omega-3 fatty acids in the treatment of depression (β=-0.11 ± 0.04, 95%CI: (-0.20, -0.01), p=0.028, R 2 =0.37) (see Figure 4 ).

Finally, the index for the (correct) answer “machine” in the machine condition was either significantly higher or with a strong trend in controls (2.6 ± 0.6) compared to both patient subgroups (DoC = 0.5 ± 0.2, U = 56.5, P = 0.028, η 2 = 0.17; NoDoC = 0.4 ± 0.1, U = 51, P = 0.014, η 2 = 0.21).

There was an overall effect of ramipril, which reduced the annualized slope of the mean maximum IMT (intimal medial thickness) versus ramipril placebo (p = 0.033), and there was a strong trend for benefit in the ramipril 10 mg/day group versus ramipril placebo (p = 0.028).

While Hb at the time of bone metastases detection was not significant when using the median value as cut-off, a strong trend for correlation between Hb ≤ 12.0 g/dL and short survival was found, p = 0.03 (when correcting for the fact that 2 tests were performed, i.e. median Hb and Hb ≤ 12.0 g/dL, the Bonferroni correction requires p ≤ 0.025).

They showed a highly significant improvement in their sense of competence in programming ( p < 0.0004) and a strong trend toward an increased sense of competence in biology ( p < 0.03) and a more positive attitude toward programming ( p < 0.023; post hoc t tests using the Bonferroni correction).

Only the difference between proximal jejunum and distal ileum showed a strong trend ( p = 0.03).

No other contrasts were significant on this measure, although again there was again a strong trend towards a greater depression of striatal DA metabolism in the MMC×10 group relative to MMC×1 group (P = 0.033, n.s.).

The presence of the high-affinity FCGR2A - 131H allele in either homo/heterozygous combinations (HH and HR) in PsA patients receiving etanercept showed a strong trend to a higher rate of EULAR response compared with those without a response (93 vs. 67 %; P = 0.034) [ 17 ].

pylori eradication was negatively associated with cancer of the bronchus and lung (HR: 0.60; 95% CI 0.44 to 0.83), and there was a strong trend towards an association between non-eradicated H. pylori and subsequent cancer of the bronchus and lung (p=0.035, table 2 ).

In aged female mice, the Sc + IL4-MSCs group demonstrated a strong trend for promoting bone formation ( p = 0.037) and showed prominent callus formation compared to the Sc + MSCs group (Fig. 2 B, D).

Additionally, Group 2 demonstrated a strong trend toward an earlier onset of MACEs compared to Group 1, with events occurring 15.58 ± 60.54 months earlier (40.31 ± 38.95 months vs. 55.89 ± 46.33 months, p = 0.04; HR: 0.62, 95% CI: 0.983–1.987, p = 0.062).

Caffeine significantly decreased 40-km time in the AA homozygotes ( p < 0.001), with a strong trend towards decreased 40-km time in C allele carriers ( p = 0.04).

For SNP2, we observed a significant association for the C allele and a strong trend for a RA linkage (AFBAC, RA index cases 66.5% versus controls 56.7%, P = 0.04; TDT, 59.7% of transmission versus 50%, P = 0.06) (Table 2 ).

However, at one month, a strong trend between reduced AD in affected nerves and RNFL thinning and mfVEP amplitude attenuation in affected eyes at six months (RNFL: R = 0.38, p = 0.04; mfVEP: R = 0.41, p = 0.02) was observed.

For both the 80°C and 90°C burns there was a strong trend of increasing perfusion with time post-burn, with B/N ratios at day 7 significantly higher than at 24hrs and day 3 (p ≤ 0.04, p ≤ 0.03). 4 Discussion An effective burn model must have reliable and consistent tissue injury.

Interestingly, inflammation level in the two groups of patients showed a strong trend towards a positive correlation ( χ 2 = 4.167, P = 0.041 ) ( Supplementary Figure 1 and Table 1 ), indicating a more pro-inflammatory microenvironment in patients with advanced fibrosis although their viral parameters and other clinical characteristics were comparable.

There was a strong trend that positive spot sign predicted short term mortality 35,9 (CI 0,857;1503,2) (p = 0,041) adjusted for age and acute haematoma volume.

In the observation group, we found favorable prognostic effects of low MUC1 expression (HR for DFS: 0.55; 95% CI 0.29 to 1.04, p = .062; HR for OS: 0.35, 95% CI 0.18 to 0.68, p = .001) as well as a strong trend for improved survival in the gemcitabine group (HR for DFS: 0.48; 95% CI 0.24 to 0.96, p = .041; HR for OS: 0.56, 95% CI 0.28 to 1.11, p = .093), see Figures 3E–H : Survival analyses in subgroups for gemcitabine vs. observation.

ACEi/ARBs (46%) and CCBs (27%) accounted for the majority of these (Table 3 ). Baseline SBP ≥ 130 mmHg (OR: 5.32; 95% CI: 0.94-29.99; p = 0.058) had a strong trend towards significance as a univariate predictor of development of HTN, and treatment with an ACEi or ARB (OR: 4.88; 95% CI: 1.05-22.84; p = 0.044) was a significant univariate predictor of development of pazopanib-induced HTN (Table 4 ).

A strong trend associated with IPV was also seen for young women who agreed with one statement of male superiority (OR, 2.298, 95% CI: 1.014–5.210, p = 0.046).

Experienced caterpillars spent a longer time in arms permeated with either DMNT or ( Z )-3-hexenyl acetate than in control arms ( N = 25, Z = −2.623, P = 0.009 and N = 22, Z = −2.256, P = 0.024, respectively), but avoided benzyl cyanide, and they showed a strong trend towards the avoidance of salicyl aldehyde ( N = 22, Z = −1.997, P = 0.046 and N = 22, Z = −1.834, P = 0.067, respectively).

[ 14 ] found a strong trend for association between the O blood type and pancreatic disease manifestation in patients with VHL syndrome (P = 0.047).

Mechanistically, rs9526814 GG genotype showed a strong trend towards reduced expression level of ATP7B compared with the TT+TG genotypes ( p = 0.048).