In the EGFR∩KRAS and EGFR∩BRAF comparisons, the Classical‐like variants EGFR E746_A750del and EGFR L858R showed a strong trend toward mutual exclusivity with Hydrolysis‐class KRAS G12V/D/C variants, and EGFR L858R was significantly mutually exclusive with class I BRAF V600E .
While this is still lower than is observed for the main coding region AUGs, it is a strong trend and one not observed in the downstream controls, where conserved ORFs have no noticeable enrichment for optimal AUG context.
An opposite effect was apparent in the contralateral tract, with a strong trend for NOR on axons from the deprived eye to be longer than those from the open eye.
However, in the past five years a strong trend toward the usage of machine learning (ML) algorithms has arisen [ 19 , 20 , 21 ].
However, although XBP1 immunoreactivity scores showed a strong trend toward elevation in treatment‐resistant specimens, statistical significance was not reached (Figure 1G ).
A key novel finding was that enrolment in an RCT was associated with a strong trend towards a 19% lower all-cause mortality, after adjustment for all measured confounders, including those commonly used for trial selection.
Similarly, there is a strong trend that N1ICD- mdx upregulated genes were also positively correlated to genes that were expressed at higher levels in healthy human muscles (score = 1.08, q = 0.26, p = 0.13) ( Figure 5C ).
Primary tumor location showed a strong trend, with an OR of 3.88 (95%CI 1.00–25.75) for patients with right-sided primary tumors versus patients with left-sided primary tumors.
Due to the failure to meet earlier endpoints, these renal outcomes were exploratory only in the two trials, but nevertheless both suggested a strong trend towards a protective effect with treatment, with 40% reduction in the CANVAS Program (HR 0.60; 95% CI 0.47–0.77) and 47% reduction in DECLARE-TIMI 58 (HR 0.53; 95% CI 0.43–0.66).
All graft failures occurred in patients with persistent PVN with a strong trend toward an increased graft failure rate in class 3.
We found the duration from the first to the last lying rest event increased after renovations for Asali and showed a strong trend of increasing with Gina (mean value for after renovations exceeded the 94.7% CI), further suggesting that the rubberized flooring may extend the duration of lying rest behavior throughout the night.
We reported that 12 months of chronic ethanol consumption in male rhesus macaques resulted in a strong trend for a reduction in osteocalcin and reduced cancellous bone formation ( Kahler-Quesada et al., 2019 ).
Poor recanalization (mTICI 0–1 and 2A) in our cohort led – as expected – to significant temporal decline of total ASPECTS compared to complete recanalization (mTICI 3), however, there was only a strong trend in comparison between mTICI 2B and mTICI 3 ( Table 2 , all patients).
In a recent study of the methylation profiles of 1,413 CpG sites, Christensen and colleagues (2010) showed a strong trend toward decreased DNA methylation with increasing alcohol intake, and a trend toward increased methylation with increasing dietary folate.
Spearman correlation analysis indicated a robust positive association between the OB and T variables ( r = 0.8728), suggesting a strong trend of similar ranking order in their variations.
A strong trend of improved predictions of peak moth catches observed with DD compared to ordinal date was reflected in time series analysis using ARIMA model.
Classification of tree species The classification results for monotemporal surveys, and for a single camera flight, reveal a strong trend ( Table 2 ).
OS analyses revealed a strong trend of increased OS with high HRs in favor of patients with high density of CD8+ cells and low combined densities of CD163+ and FoxP3+ cells (CD8HCD163LFOXP3L) vs. high density of CD8+ cells and high combined densities of CD163+ and FoxP3+ cells (CD8HCD163HFoxP3H) in the TC and the IM ( Figure 5 C). 3.4.
However, we did observe a strong trend for increased ORs for IgM and a statistically significant effect for increased IgG for each of the SARS-CoV-2 antibodies examined.
Moreover, there was a strong trend toward lower ADP induced aggregation in male minor allele carriers of rs41273215.
CAV1 , which was also identified as a key candidate in our previous work, showed a strong trend of upregulation (a 3-fold increase) in the same global analysis, although it narrowly missed the threshold for statistical significance after correction for multiple comparisons ( P adj = 0.0709, Supplementary Data 1 ).
Interestingly, it seems that dasatinib positively impacts the expansion of CD37CAR T cells compared to their non-treated counterparts with a strong trend towards increased expansion for three out of three donors.
There was a strong trend toward decreased magnitude of global longitudinal PDSR of T2DM patients with decreased RVEF than that of healthy subjects and T2DM patients with preserved RVEF ( p < 0.05).
We observed a deviation in the effects of both dietary treatments on haptoglobin levels, where GL supplementation resulted in greater concentrations of haptoglobin throughout the experimental period, while FO supplementation had no effect on haptoglobin concentration in either the pre- or post-weaning periods, but resulted in a strong trend towards lower concentrations of haptoglobin during the peri-weaning period.
In a small dataset (Garber et al.) there was a strong trend for a worse prognosis of patients with adenocarcinomas of all stages over-expressing the “Fibroblast specific BMP2 induced gene list”.