“a strong trend”

Furthermore, we found a strong trend for an increase in pTDP-43 levels in the hippocampus of the HD group.

While neuronal proportions were similar between human-chimpanzee, macaque and marmoset neuronal proportions were greater than human with either statistical significance or a strong trend (Supplementary Data 2 and Fig. 2A ).

After 24 hr, we observed a strong trend toward decreased tissue levels of accumulated Aβ40 and significantly lower accumulated Aβ42 in the presence of HDL ( Figure 4g–h ).

Interestingly, ischaemic core/penumbra lesions were seen in a subset of patients with TIA, and there was a strong trend for the absence of core/penumbra lesion to predict mimic from TIA in multivariate analysis ( Table 4 ).

These peptides failed to elicit significant protection in the urine, bladder, or kidneys of mice, however, there was nearly a 2-log reduction in CFU/g in the kidneys for both IroN ( P = 0.053) and IutA ( P = 0.078) peptides, demonstrating a strong trend towards protection ( Fig. 1F ).

However, despite a strong trend towards an impaired prognosis in patients with low TWEAK serum levels (below 808.3 ng/mL), this ideal cut-off value was still unable to significantly identify a subgroup of patients with an impaired overall survival ( Figure 3 D).

Particularly, there has been a strong trend towards device miniaturization since smaller implantable devices are desired to make them compatible with normal human activities and enhance the comfort of the host 19 , 20 .

Phee calls did not differ significantly, but showed a strong trend ( Table 1 ).

However, the cumulative risk of all-cause death showed a strong trend towards increase but did not reach statistical significance (HR: 1.23; 95% CI: 0.99–1.51; P = 0.052).

S3B, D, E ), but there was a strong trend for RG activation decrease in 8dpf larvae (Supplementary Fig.

As shown in Figure S3 , the further restricted cubic spline showed a strong trend toward nonlinear positive association of continuous NFS, FIB‐4, and AST/ALT ratio with primary outcomes.

In the final model, RA duration (β = 0.45, p < 0.001) and CD4/CD8 ratio (β = 0.28, p = 0.012) emerged as significant independent predictors of carotid IMT ( Figure 4 ), while age (β = 0.20, p = 0.07) showed a strong trend.

High antibiotic usage in adults is corroborated by health-care utilisation surveys done in LMICs that show a strong trend for adults to access community pharmacies as first point of contact and to self-medicate with over-the-counter antibiotics; 39 , 52 , 53 , 54 however, the prevalence of antibiotic usage in children might over-estimate that in adults due to the higher frequencies of paediatric respiratory infections and health-care visits. 37 Limited data on the sales and use of suboptimal (substandard or falsified) antibiotics exists and, therefore, has not been incorporated into our analysis. 55 , 56 The IQVIA MIDAS database is a proprietary database, restricting access and analysis.

Overall, there was a strong trend toward fewer deaths when compared to placebo control.

While there is no statistical significance when comparing CMD and DXS, there is a strong trend toward CMD having higher colocalization.

As a result, a retrospective analysis showed that the majority of the compounds occupied a narrow range of CNS MPO scores ( Figures and a, 75% between 1.5 and 2.5), and utilizing CNS MPO scores to triage compounds for screening resulted in numerous false negatives as the calculated scores did not correlate with the data observed in the in vitro MDCK and in vivo K p,uu assays ( Figure c–e). On the other hand, and contrary to the initial results observed in the benzazepine series, a strong trend was observed with the tolyl series ( Figure b) between the in vitro MDCK assay and in vivo K p,uu , with 75% of compounds with in vitro ER < 3 demonstrating K p,uu > 0.3 in vivo ( Figure d,e).

Paradise Pond and SV5 also had low magnitude Hg enrichment [ 32 ], which matches the low levels of 210 Pb deposition at these sites–such that a lack of a strong trend due to low Hg deposition was foreseeable.

In the first part of that period, until 2015, the number of published research papers is characterized by a level pattern, while the second part, starting from 2015, shows a strong trend of growth in the number of publications.

Specifically, introduction of sensor networks and intelligent automation systems represents a strong trend, as shown in the state of the art of drying processes.

Herein, ambulatory IGF-I and GH+IGF-I treated animals showed a strong trend of increased IGF-I receptor expression, although this trend was not significant (Fig. 8 ).

Although no formal test for superiority was performed, the early group showed a strong trend toward a significant reduction in the risk of early stroke recurrence.

Gene Expression of Enzymes of the n-3 Fatty Acid Pathway in the Liver The liver gene expression was significantly affected by the dietary content of CA and SA ( Figure 5 a–c); the higher dietary content of SA induced a strong trend towards lower liver gene expression of both Elovl5, Fads1 , and Fads2 .

In contrast to the amygdala, the hippocampus showed a strong trend toward an opposite pattern of interaction in the counterconditioning phase, where hippocampal activation was increased by reward in CS− but not CS+ trials.

Risk factors that are significant, or show a strong trend, after adjustment, will also be considered as candidates for ergonomic models incorporating the “best” independent predictors of events.

Compared to previously reported colorimetric assay-based approaches 29 – 32 , utilizing growth as a simple readout afforded higher throughput which enabled us to observe a strong trend of convergent evolution: multiple NMN + -reducing variants employ very different sets of mutations to achieve the same predicted mechanism (recapitulating AMP) to enhance the NMN + -dependent activity.