“a strong trend”

159 ± 19 MΩ in Pten -/- rapamycin, p < 0.05), but they displayed a strong trend of having a reduced time constant (4.4 ± 0.3 ms in Pten -/- vehicle vs. 2.8 ± 0.2 ms in Pten -/- rapamycin.

After normalizing cleared area to spheroid starting size to account for differences in spheroid viability due to loss of CAMKKβ (as recommended 39 ), we identified a strong trend toward decreased invasive potential in OVCAR8 CAMKK2 KO spheroids but observed no effect in HeyA8 CAMKK2 KO spheroids (Fig. 3 B).

Although there was a strong trend that good response lesions tend to have higher levels of melanocyte-signature gene expression, there was a wide range of variation, making the difference non-significant statistically.

360 mg dose administered 3 times, did show a strong trend of higher antibody response, further studies are warranted to examine even higher and more frequent doses in order to establish the best conditions for clinical improvement.

Only during Week 10 was a strong trend ( P route = 0.059) detected, relative milt volume (roughly 1.5% of body weight) in IM-injected eels being almost double that of IP-injected eels; injection dose, on the other hand, did not have any effect ( P dose = 0.256).

Moreover, lysine-free ataxin-3 (K0) showed significantly lower protein levels for its 15Q form as well as a strong trend toward reduction for Atx3 70Q when compared to the unmutated counterparts.

We noticed, however, a strong trend towards better adherence to the international standards over the study period: in the years 2016 and 2017, 68.6% compared to 82.7% of children in the years 2018 and 2019 were treated according to ETROP criteria.

Accordingly, PKA treatment of isolated cardiomyocytes decreases myofilament calcium sensitivity significantly in HCM 173 and with a strong trend in HCM 234 ( Fig. 6D – F , Table S5 ).

While the difference in reactivity to K5Me2 between SLE patients with high and low IFN signatures did not reach statistical significance by ELISA, there was still a strong trend toward greater reactivity in patients who had high IFN signatures.

For instance, CTLA-4 inhibitors were associated with a higher incidence of colitis and diarrhea, while PD-1 inhibitors showed a strong trend toward immune-related AEs, again, congruent with the current literature [ 29 , 30 ].

Although none of these trials, other than CLOT, demonstrated statistically significant differences between LMWHs and warfarin, there was a strong trend favoring LMWHs in all the studies.

Even though some patients were staged as organ confined disease at the beginning, the disease had a strong trend to progress and became metastatic.

Across these comparisons there was a strong trend of increasing f with time ( Fig. 3C ; Table 2 ).

Postoperative pain scores did not differ between the groups; however, the results did show a strong trend of higher pain scores across the groups with the intervention group having the lowest pain score and the non treatment group, having the highest pain score.

Conclusion Our data show a strong trend towards lower patient and operator exposure during percutaneous coronary procedures in the period 2013–2019.

Differentiating from JMDC claims, patients treated with olanzapine only exhibited a strong trend in developing triglyceride abnormality, while triglyceride levels from patients in JMDC claims were passively influenced.

There was a strong trend for TS positive tumours having a poor prognosis, however, which is consistent with the published literature.

Weaknesses: There is not significance found in the proliferative assessment of the SVZ, in that both WT and HCAR1 mice have reduced proliferation (did not reach significance, however, the figure Supp 1F suggests a strong trend).

Moreover, the same survival analysis, divided by implant position, ( Figure 4 ), displayed a strong trend in favor of prepectoral position, with an incidence of any complication at the end of follow-up for prepectoral position of 66.6% (CI: 47.5%, 93.4%), and of 52.53% for subpectoral position (CI: 35.7%, 77.2%) ( p -value = 0.0992).

The statistical analysis with 2-way ANOVA showed clear differences of means with regard to capsazepine treatment and a strong trend toward an interaction effect of PON2 status and capsazepine exposure. 3.5.

Generally, there is a strong trend of ACh being more frequently used at the downstream end of the signaling flow within specific motifs, while Glu tends to be located at upstream positions within motifs ( Figure 3E ), which is consistent with the processing depth analysis described above ( Figure 3D ).

Interestingly, the comparison among the taxa belonging to the most representative Phyla of the samples by NMDS showed a strong trend to group by Lake (Figure 5A ) due to a clearly higher abundance of phototrophic microorganisms in LN (Figure 5B ) than in LE.

In parallel, there is a strong trend towards the integration of MALDI-MS with other analytical techniques in a multi-omics approach.

Most of the measured muscle contractions were clustered close to the mean difference line, and lay within the 95% limits of agreement, suggesting a strong trend for agreement between dyna-torque and predicted MC torque [ 27 ].

1D ) and although there was a strong trend towards increased motor unit survival in the TA muscles of metformin-treated male SOD1 G93A mice compared to their untreated counterparts (20+/−4 vs. 16+/−2 motor units respectively), this did not reach significance ( Fig. 1D ).