The results were considered inconsistent as the largest cohort with the longest follow-up showed potentially a slight protective effect of NSAIDs, whereas a population-specific study (knee osteoarthritis) showed a strong trend (not quite reaching statistical significance) of increased all-cause mortality. 3.5.
However, there was a strong trend toward more pulmonary comorbidities and higher BMI in the conservative management group, probably reflecting concern for procedural and anesthesia tolerance.
Furthermore, the more stable personality-inherent feature of anxiety proneness (trait anxiety) showed a strong trend toward reduction.
Biological validation of our microarray data by Real-Time PCR confirmed significant results for CCL-12, MIF, FN-1 and GJA-5, while there was only a strong trend towards upregulation for CXCL1, CCL 6, EGFL 7 and TIMP.
Interestingly, we did not observe significantly increased proliferation of hMPCs, though there was a strong trend in male hMPCs, in an in vitro monoculture.
In addition, the use of biomass has proven to be a strong trend in the plastics industry because of the environmental footprint, high specific mechanical properties, biocompatibility, and transfer properties.
42 , 43 We observed a strong trend of reduction of SAA in the Rec2-FGF21 group as compared to controls ( Figure 5 K).
At that time, WT mice that received KA actually displayed a strong trend towards an increased expression compared to vehicle-treated mice, although this effect was not statistically significant (Figures 5A and C ).
A strong trend was observed when RCM was used to direct mutational studies: significant impacts on function were frequently observed for mutations in regions that RCM predicted as conserved, while impacts were rare for mutations in non-conserved regions.
Consistent with our data, these studies demonstrated a strong trend toward a significant difference in outcome according to the LGE extent.
This anti-inflammatory effect was evidenced by a marked downregulation of key pro-inflammatory cytokine and chemokine gene expression, including MCP-1 and IL-1α, with a strong trend toward reduced TNF-α expression ( Harari et al., 2020 ).
HIIT showed a strong trend in improving lipid levels, particularly in increasing HDL levels, which was the most notable effect.
At P90, LPS groups of both sexes showed slightly decreased locomotor activity in comparison to control rats ( Figure 6 b, Table A7 ), although 2wANOVA showed only a strong trend.
Tryptophan metabolism appears to play the most dominant role in immune tolerance in GBM, with over a two-fold increase in Tregs and a strong trend in decreased CD8+ T cells.
[ 9 ] concluded that presence of pain was significantly associated with adverse employment outcomes and indicated a strong trend with regard to complete unemployment.
guideline BP lowering and found no significant reduction in recurrent stroke (Supplement Table S2 ); however, there was a strong trend to reduced recurrence and meta‐analysis of this and other data in SVD might well show a significant effect.
Figure 2A shows a strong trend for a larger a-wave amplitude ratio across all flash stimuli.
At this time point, the 177 Lu-PSMA617 + genistein group exhibited a 78.1% reduction in tumor volume compared to 177 Lu-PSMA617 monotherapy, while the 177 Lu-PSMA617 + baicalein group showed a 50.2% reduction, demonstrating a strong trend of enhanced efficacy, although these differences did not reach statistical significance ( P > 0.05) (Fig. 4 B).
Public health concerns have to a great extent been transported to the developing world where there is a strong trend toward increased use of asbestos, although it has been virtually eliminated from commerce in most developed countries.
Ex Vivo Response of Ascending Aorta Segments to Vasoactive Agents A strong trend towards an age-dependent decrease in the phenylephrine (PE)-induced vasoconstriction was observed in untreated animals: the aortic diameter decrease was of 17% in aged mice compared to 20% in adult animals (one-way ANOVA, p = 0.06; Figure 6 A).
In therapeutic communities, there is a strong trend towards moving away from aggressive confrontation, and treatment models that have traditionally relied heavily on concepts such as “denial” are incorporating principles of respectful communication ( Crits-Christoph et al , 1999 ).
OS data were not mature, however, there was a strong trend towards an improved OS in the pyrotinib arm (HR 0.46; 95% CI 0.22–0.99).
Consistent with lower TNFa expression, we found a strong trend for reduced IL-6 mRNA levels upon C3 lowering, confirming a less inflammatory microenvironment in APP;C3 iKO mice.
( 2005 ) found a strong trend for improved prandial glucose tolerance, while Yarar‐Fisher et al.
The nature of this pattern in population genetic structure was obvious from the spatial allele frequencies of many of the gradient SNPs (Figure 4f ), and was also supported by the analysis revealing a strong trend of genetic isolation by distance with all markers (Figure 5a–d ).