8C7-ADCs also appeared well-tolerated at the concentrations used in our experiments, with only a slight trend of weight loss in mice treated with PBD ADCs (both 8C7 and control IgG), indicating minimal non-antigen-related uptake in normal tissues.
25 , 26 , 27 In the present study, we did not observe significant better response rates in patients with irAEs ( n = 17), although we saw a slight trend of a better mOS and mPFS in this subgroup of patients.
Although it was not studied in detail and further studies should be done, a slight trend to hyperactivity in males and hypoactivity in females can be observed before treatment with MK-801 (Li et al., 2007 ; Pletnikov et al., 2008 ; Ma et al., 2013 ).
Results of our analysis demonstrated that there is a slight trend for lower CL/F when CL CR is reduced in renally impaired subjects or when the Child–Pugh score is increased in hepatically impaired subjects.
However, there was no reliable effect of value itself and, if anything, there was a slight trend toward stronger memories for lower trial values ( Fig. 6b column 4; mean [95% CI] value coefficient = −0.03 [−0.05, 0.0001]; Supplementary Table 1 ); this did not replicate in our second experiment (see Experiment 2 below).
Challenge with HeV or NiV-B following treatment did not significantly impact the resultant nAb titer; however, there was a slight trend towards increasing homologous PRNT50 titers (challenge with NiV-B increases NiV PRNT50, challenge with HeV increases HeV PRNT50).
Meanwhile, in the right ears, the trend was the opposite, with the Wave V amplitudes and amplitude-to-latency ratios showing a slight trend of differences between controls and T-4 participants and no difference for Wave V fast-rate latency.
barbadense , with a slight trend of decreasing expression over time and very high expression at 5 and 10 DPA in wild accessions.
There was a slight trend of increase of total fat mass in Adipoq −/− mice, but it did not reach statistical significance (Fig. 1b ).
The time series plotting displays a good overall correlation between observations and forecasted values, however, there is a slight trend to underestimate the maximum peaks.
Analysis of the Mobility domain demonstrates a slight trend towards improvement over time, with 76.3% of PwHA reporting ‘no problems’ or ‘slight problems’ at Week 73 (n = 90/118) compared with 70.6% at baseline (n = 120/170). 3.5 Work absences With emicizumab, fewer employed participants missed workdays than in the 28 days prior to study enrolment (Figure 5 ).
There is also a slight trend that a static start procedure increases the proportion of more discrete trajectories.
Although the QLB group demonstrated numerically lower PONV incidence and a slight trend toward delayed TFAR, these changes did not reach statistical significance and should not be interpreted as evidence of clinical benefit.
The year of publication showed a negligible correlation to the inclusion of ADEs, although a slight trend was observed with more recent publications excluding ADEs more often than older publications.
We observed a slight trend for improved disease control rate in the PD-L1 <1% patient groups who were AE sig+ compared with AE sig– ( Figure S3 ).
Further studies have shown that NHEJ is not ubiquitous in bacteria, but is found in approximately 20–25% of the kingdom, with a slight trend to species containing larger genomes with higher GC content and slower growth rates ( McGovern et al., 2016 ).
SXT-resistant spectra largely overlapped with susceptible isolates but displayed a slight trend toward divergence (Fig. 3 A).
The color change in Figure 8 c is small, indicating that the effect of the DMP-30 accelerator on toughness was small, and there was a slight trend of initial increase followed by a decrease. 3.5.4.
Discs treated with HA showed a slight trend of improvement over time.
There was also a slight trend toward agreement with the statement “the level of my child's (capacity) (below average, average, above average) is not relevant.
A slight trend is observed toward higher diffusion lengths with increasing temperature and RH from 40 nm at 80 °C/0% RH to 55 nm at 120 °C/0% RH and 70 nm at 120 °C/70% RH, as shown in Figure 5 c.
There was a slight trend toward fewer cells with increasing light exposure at Day 1, but these values were no different than the range of values found among the mock samples, and the trend was not significant ( p = 0.78, ANOVA for difference of the means).
There was a slight trend towards higher SIM concentrations in patients with cirrhosis.
In the first place, although there was a slight trend of higher trust and competence evaluation for the standard German-speaking compared to the dialect-speaking robot for all participants, the difference was not statistically significant.
These alterations in cell composition did not significantly impact overall cortical thickness at E14.5, although there was a slight trend in reduced medial thickness ( Figure 3—figure supplement 1F ).