“a significant trend”

Compared to no-DKD, RI was higher in all DKD PHs, being the highest in MA-DKD and with a significant trend of RI >0.70 prevalence to increase across PHs (p=0.022). aTRV3D and aPRV3D significantly differed across PHs (p<0.0001 for both).

However, when the clinical grades were analyzed as ordered categories, a significant trend across groups was observed ( p = 0.022), suggesting a graded association that should be interpreted cautiously ( Figure 2 a).

For 5α/β-reduced steroids, most had significantly lower levels in patients (n = 10), while fewer showed no change (n = 5) or higher levels (n = 1), indicating a significant trend towards lower levels ( p = 0.022).

Patients presenting IMH exhibited a higher prevalence of pre-procedural TIMI flow grade 0 compared with those without IMH (82.9% vs 78.0%), with a significant trend difference in pre - interventional TIMI flow grades between the two groups ( P = 0.022).

A significant trend from low to high IMI-MD adherence was also observed ( p = 0.022), with a lower neutrophil percentage in the high adherence group.

When the clinical course of BCVA (LogMAR) from IVAn-2 to IVAn during IVA treatment was analyzed, a significant trend of worsening was found ( p = 0.022).

As with risk of hospitalisation, there was also a significant trend towards more severe ESC complexity being associated with increased risk of death (p=0.0229; mild/moderate OR=1.55 (1.30 to 1.84) and severe OR=3.09 (1.66 to 5.41)).

Multivariate analysis identified a significant trend for surgical site occurrences in nonclean cases ( P = 0.023).

However, this largely reflected a significant trend in the population aged 80 years and older, increasing by 0.89 (95% CI: 0.15–1.63) visits per 100,000 persons per year (p = 0.023), with other age groups remaining stable ( Fig 5 ).

Patients in the highest CRP tertile had significantly higher odds of events compared with those in the lowest tertile (OR 4.47, p = 0.023), and a significant trend across tertiles was observed ( p = 0.023).

Hypertension stratification ( Supplementary Table 4 ) revealed significant associations for all indices in non-hypertensive participants (all P for trend < 0.001), whereas in hypertensive participants, only FM/LBM showed a significant trend ( P = 0.023).

Using an ANOVA analysis, there was a significant trend for differences in S-100 β biomarkers levels over the entire time period ( p = 0.023).

When TP53 status was modeled as an ordinal variable, a significant trend toward worse PFS was observed (HR per step 1.28, 95% CI 1.03–1.59; p = 0.023).

Univariable conditional logistic regression There was a significant trend for developing IBD with a higher number of self-reported cigarettes per day (p = 0.023), but there was no significance in the risk for IBD when analysing each category of number of cigarettes ( Table 2 ).

Despite the non-significant estimates of medium and low status, a significant trend in the association between peer status and circulatory disease can still be detected (p=0.023).

Non‐native species also showed a significant trend toward earlier peak movements ( F = 5.24, p = 0.023; Figure 5c ), with the model predicting a decrease from day 159 in 1997 to about 140 by 2023.

However, we observed a significant trend change in the quarterly prevalence of NSAIDs use in females during the pandemic (β 3 = 0.0869 and P = 0.0232) compared to the pre-pandemic period.

The OR (95% CI) for periodontitis were 1.09 (0.99–1.19) in working group of 40< and ≥52 and 1.10 (1.01–1.20) in working group of >52 hours per week with a significant trend (p = 0.0233) even after adjusting for age, socioeconomic status, healthy behaviour, chronic disease, and dental care status.

During the progression from normal human melanocytes (n = 1) over melanoma in situ (n = 2) and primary melanoma (n = 14) to metastatic melanoma (n = 41) there is a significant trend of increase of CXCL1 gene expression (p = 0.0237).

There was a significant trend as the prevalence of protective immunity against tetanus decreased rapidly with increasing age till age 13 years (35.0%), (p = 0.024).

They also found a significant trend of increased methylation in tumor samples of higher clinical stages for both miR-9-1 ( p = 0.024) and miR-9-3 ( p = 0.040).

A significant trend was observed only among those aged 20–39 years (AAPC: 2.6%, 95% CI: 0.4%–4.8%, P = 0.024).

Results Compared to the reference group, the social class adjusted ORs for the high and very high contact categories were 8.18 (95% CI 0.95 to 70.33) and 14.90 (1.20 to 184.90), respectively, with a significant trend across the categories (p value=0.024).

At V2 there was a significant trend of rising diversity based on the Shannon diversity index (trend p = 0.024).

In the extant haplotypes, there is a significant trend where each substitution adds on average 3.25 kcal mol −1 (ANOVA p = 0.024; FoldX.