“a significant trend”

In contrast, antidiabetic therapy demonstrated a significant trend across SI quartiles ( P = 0.011).

Compared to the subjects without risk genotype, we found a significant trend toward increased risk for subjects carrying 0–3 risk genotypes (adjusted OR = 1.29, 95% CI = 1.06–1.56, P = 0.011).

Binary logistic regression analysis showed a significant trend of association between TNK treatment and lower END risk [odds ratio (OR) = 0.069, 95% confidence interval (CI): 0.009–0.545, p = 0.011].

A significant trend for decreased risk of early AMD with increasing SFA intake was noted ( P = 0.011).

Moreover, we observed a significant trend towards a decline in urine phosphate excretion, visible as early as the third month of treatment (0.53 ± 0.18 vs. 0.44 ± 0.17 g/24 h; p = 0.011).

The relationship between FS and FNPA was explored, and a significant trend was noted with FNPA scores in this population; however, a limited range of FS scores may have affected this finding ( β = 0.534, CI 0.126, 0.941; p = .011).

Neurons with a higher resistance showed a significant trend for shorter and more intense rebounds compared to neurons with a lower resistance (50 ms rebound R 2 = 0.103, P = 0.011; 100 ms rebound R 2 = 0.1503, P = 0.0011; and 250 ms rebound R 2 = 0.048, P = 0.068).

Results: After adjusting for covariates, a significant trend was found between the dietary iron and elevated fasting glucose ( p = 0.012), whereas no such trend was observed for the rs864745 ( p = 0.932).

They found a significant trend for declining total cholesterol from 2006 to 2015 in the ACS population (p = 0.012).

Clinical evolution was significantly associated with time since first presentation (Exact p = 0.03) with a significant trend of worsening evolution with increasing follow up time (categorized as < 5y, 5–9y, ≥ 10y) (z-test for trend p = 0.012).

The ITS analyses confirmed a significant trend in the decrease of intravenous (IV) vancomycin utilization ( P = .012) ( Appendix Figure 3 ); however, despite overall reductions, there were no significant decreases in slopes of any additional antimicrobial category, including total antimicrobial ( Figure 2 ) and fluoroquinolone utilization ( P = .709) ( Appendix Figure 4 ).

Regression analysis shows that there is a significant trend toward increased levels of late apoptosis and total apoptosis with increasing statin concentration (Linear regression: p = 0.012 (r = 0.79) and p = 0.019 (r = 0.75) (late and total apoptosis for lovastatin), p = 0.003 (r = 0.86) and p = 0.044 (r = 0.46) (late and total apoptosis for mevastatin), p = 0.014 (r = 0.77) and p = 0.038 (r = 0.69) (late and total apoptosis for simvastatin)).

Only women delivering at Katoro rural health centre had a significant trend towards increased odds of peripheral malaria by microscopy in both bivariate (OR = 1.72, p = 0.012) and multivariable analysis (AOR = 2.77, p = 0.014).

After adjusting for age, sex, smoking status, and use of lipid-lowering and antihypertensive medications, we determined that participants carrying the minor alleles of the rs117685211 genotype exhibited a significant trend of higher levels of Ox-HDL in the additive and dominant models ( p = 0.012 and 0.002, respectively), and conversely showed a significant trend of lower levels of ApoA1 and HDL-P (including L, M, and S-HDL-P; all p values were ≤0.001 in the additive and dominant models).

Thus, trend analysis for the presence of AGR across quartiles of activin A demonstrated a significant trend for the odds ratio (OR) of having AGR at 3 months with increasing activin A concentrations ( P = 0.012), identifying a threshold of activin A at the median value (≥0.23 ng/mL, Fig. 2 ).

Importantly, there was a significant trend indicating that as D-dimer levels rose, the risk of mortality also increased ( p for trend, HR 1.15, 95% CI = 1.03 ~ 1.28, p = 0.012).

In ATAAD patients ( Table S3 ), higher LAR tertiles (T3 vs T1) were strongly associated with in-hospital mortality even after full adjustment (OR = 2.19, 95% CI: 1.22–3.94; P =0.009), with a significant trend (P =0.012).

A significant trend was also observed in summer (p = 0.012) however it differed by N-deposition treatment with MN (72.71 g C kg −1 ) ≥ LN (65.63 g C kg −1 ) > CK (50.97 g C kg −1 ) ≥ HN (46.39 g C kg −1 ).

Familiarity with Nutri-Score increased monotonically across educational strata, from 30.5% in upper-secondary/vocational respondents to 33.3% in post-secondary non-tertiary, 38.7% in university, and 48.4% in postgraduate respondents, with a significant trend across ordered educational levels (Spearman ρ = 0.14, p = 0.012); the omnibus four-group χ 2 did not reach significance (χ 2 = 6.27, df = 3, p = 0.099), consistent with a graded rather than threshold effect.

Similarly, a significant trend was also found between mean age and blood loss in the NE (Omnibus p = 0.012) and CR (Omnibus p = 0.04) groups (Supplementary Figure S21‐22 ). 5 Discussion NE evacuation was initially suggested by Auer et al. and has since developed into a potentially effective surgical technique for managing spontaneous supratentorial ICH due to its high evacuation rate, superior protection of the surrounding brain tissue, and lower complication rates (Ye et al. 2017 ; Zhang et al. 2014 ).

The log rank analyses ( Figures 1 and 2 ) showed that the RFS and OS were significantly different among the quartiles with a significant trend towards worse survival in more deprived quartiles ( p = 0.012, and 0.011, respectively).

The heavy chains of mAbs, but not the light chains, showed a significant trend ( P =0.012) to greater divergence from germline with increased time between infection and peripheral blood mononuclear cell (PBMC) collection ( Fig. 8e ).

For male rat blood leukocytes (both modulations), results from scoring 100 cells were negative; however, equivocal responses were seen with the 150‐cell method based on a significant trend test ( P = 0.012) or pairwise test ( P = 0.021) for CDMA‐ and GSM‐exposed rats, respectively (Tables 1 and 2 ).

Moreover, linear-by-linear association analysis demonstrated a significant trend ( p = 0.013), indicating that higher tumor grade was associated with an increased risk of death within two years. 4.

Critically, the fundamental linear dose-response relationship was reaffirmed by a significant trend across quartiles (p = 0.013) and a consistently positive continuous association in both the primary (HR 1.38 per SD) and sensitivity (HR 1.65 per SD) models.