“a significant trend”

Research shows a significant trend toward earlier menarche over the past 50–100 years, with the prevalence of early menarche (before age 11) and very early menarche (before age 9) nearly doubling across birth years from 1950 to 2005.

There was a significant trend toward the positive relationship between achieved VE levels and blood pressure.

Smolts did not display a significant trend to changes in ( n -6) PUFAs in all of the experimental groups.

On this absolute scale there is a significant trend in treatment effect by risk groups: for low, medium, and high‐risk groups the rate differences are −0.64, −1.86 and −3.93 primary events per 100 patient‐years, respectively ( p for trend = 0.026).

It revealed a significant trend towards an increase in hospitalizations for endometriosis in France with time.

Although there was no statistically significant trend in the change of the absolute disparities in all-cause mortality between Black and White patients during 2000–2019, a significant trend in the change of relative disparities was found, highlighting the methodological importance of reporting both absolute and relative measures of disparities to provide a clear picture of health disparity change across races.

The lack of a significant trend in pulse wave velocity and augmentation index measurements, as surrogate markers of aortic stiffness, would suggest that there is no clinically relevant impact following the administration of iron in non-dialysis-dependent CKD or atherosclerosis secondary to an increase in selectins.

Interestingly, CRP, a common marker of inflammation, failed to show a significant trend in this study.

This observation indicates a significant trend in their prevalence (Supplementary Fig. 1 ).

Bio-fermented palatants represent a significant trend towards leveraging natural processes to create unique and appealing aroma profiles.

A significant trend in multiomics research is the use of AI to identify biological pathways and biomarkers ( Zhao et al., 2025 ).

Compared with nonsmokers, the HR (95% CI) for all-cause dementia events for those who started smoking before the age of 15 years, between 15 and 18 years, and at the age of 18 years or older was 1.33 (1.19–1.48), 1.15 (1.07–1.23), and 1.18 (1.10–1.27), respectively, showing a significant trend ( P -trend < 0.001).

Furthermore, recordings in two control animals during the equally probable passive presentation of the two pitches revealed a significant trend toward a larger P2 amplitude in response to the low pitch as compared to the higher pitch.

The Cochran-Armitage method was used to test for trends in the distribution of categorical variables across months, whereas, generalized linear regression was used to determine if there was a significant trend across the study period in continuous variables.

[ 14 ] are clear that indoor guidance and assisting via smartphone will become a significant trend in modern buildings.

Although the initial AI-assisted accuracy was significantly higher in expert (91.9%) versus non-expert (82.3%) endoscopists, there was a significant trend over time in non-experts, such that, for the final 50 polyps, there was no difference in NPV for non-experts (95.2%) versus experts (93.9%).

The Cochran-Armitage trend test was used to detect whether there was a significant trend in the probability of disease progression or reversal with an increase in the risk level.

There is a significant trend in the patterns of collaboration between authors, where decades of research in the field of drama therapy show a significant and growing shift from single-authored to team-authored research.

In addition, by comparing the mean hardness values of the optimal and control samples, a significant trend was evident in each day of storage.

Among the studied tumours, NB and the group of COET presented a significant trend in children, with APCs of 1.4% and 3.8% respectively.

In early drought response, we detected a significant trend towards the accumulation of flavonoids, including flavonoid‐ O ‐hexoside‐2 (Figure 7b ), as well as non‐significant increases in luteolin and quercitrin, all approaching WT levels (Figure S7d ).

On average, almost half of PWD (46.3%) had an HbA 1c above 7.0%; a significant trend toward higher values over the 10-year period was observed.

Ever use was not associated with increased risk (RR = 1.0), but a significant trend was observed with increasing years of use, with users of 20 or more years being at a 50% excess risk.

A study using data from 11,342 disease-free women in the Nurses’ Health Study showed a significant trend of lower (higher for adiponectin) biomarker concentrations with greater adherence to the cancer prevention recommendations in the WCRF/AICR 2007 report [ 23 ].

There was a significant trend for applying a higher IMN radiation dose (EQD2 > 50.0 Gy ) in patients with TNBC, multiple IMN adenopathy involving multiple intercostal spaces (ICS), IMN size measuring ≤ 0.8 cm, or cytology-positive IMN ( Table 3 ).