The group switched to oral β-blockers showed a significant trend towards a lower LVEF (P<0.001) and was more likely to have a heart rate >140 beats/min (P=0.003) and systolic blood pressure (SBP) >120 mmHg (P<0.001) at the time of landiolol initiation.
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Upon stratification of the study population by quintile of salt consumption, a progressive increase in iodine intake was apparent across quintiles with a significant trend (Jonckheere–Terpstra test for trend, p < 0.001) in the whole population and both male and female participants ( Table 2 ).
A significant trend ( P <.001) of increase in sharing of glass/bottle during training was observed.
Compared with controls, mean IGFBP-2 SDS were significantly elevated in patients with Dukes B ( P < 0.001), Dukes C ( n = 13 P < 0.001) and advanced disease ( n = 42 P < 0.0001), with a significant trend from early to advanced disease (one-way ANOVA P < 0.001).
First, the correlation pattern between sucrose intake and abundances of the 116 genera compared with that between the sucrose index values and the same abundances showed a significant trend for the respective rankings ( p < 0.001; Figure 5 ).
The sexual subscale was statistically significant in the severe group (PR: 4.45, 95% CI: 2.06–9.61). All scales showed a significant trend at the p <0.001 level.
A significant trend to older age was observed over time in the overall population and deceased patients ( p < 0.001).
By contrast, in subjects without renal arterial calcification, a significant trend in the prevalence of arterial calcification according to perirenal fat thickness was found ( P <0.001 for all in the crude analysis) ( Table 3 ).
Limiting the analysis to the IBIS period reveals a significant trend for fewer IVH (p=0.001).
Further, the number of sickle-shaped blood vessels was associated with distant metastasis and OS, with a significant trend toward a poor prognosis (metastasis P < 0.001, Cox; OS P < 0.001, Cox) observed for patients with more than 100 such vessels in large maximal tumor sections.
For RCII, the association was stronger and more consistent: per SD increase (OR 1.23, 95% CI: 1.00–1.51, p = 0.046) and Q4 (OR 5.20, 95% CI: 2.24–12.08, p < 0.001) both showed significant independent associations, with a significant trend across quartiles ( p < 0.001).
Embryo growth rates (expressed as % increase from beginning to the end of embryogenesis, and mm day −1 ) increased significantly under the present-day scenarios, but there was a significant trend reversal at future summer conditions (red symbols, 19°C, Fig. 1C,D, F = 92.3, p<0.001).
Those with RNF213 RV without p.Arg4810Lys exhibited a significant trend toward poor DTA development ( P = 0.001).
A Cochran-Armitage trend test across four ordered categories (no cough, mild, moderate, and severe cough) showed a significant trend toward lower cough severity in the tegileridine group (Z = 4.11, P < 0.001).
Patients with high serum CRP level showed a significant trend toward worse RFS compared to the RFS of patients with low serum CRP levels ( P < 0.001, Kaplan-Meier Method) (Fig. 2b ).
There was a significant trend for with increasing race distance ( p < 0.001) with both failure to finish and pulled-up.
There was a significant trend of stepwise increases in CV events among the four groups (5.2%, 7.3%, 15.4% and 31.0%, respectively; p < 0.001 for trend).
When stratified by RFM tertiles, a significant trend was observed, with higher RFM tertiles being more prevalent among participants with asthma ( P < 0.001).
Among men, a significant trend was found, both with regard to individuals without hypothyroidism ( p < 0.001), and with hypothyroidism and levothyroxine treatment ( p = 0.021), while no such association was found among women.
The P values are indicated for the lowest dose with a significant effect (indicated by a single asterisk [*]) and curves with a significant trend (indicated by a pound sign [#]). ###, P < 0.001; # or *, P < 0.05.
A significant trend for decrease in TSH values was determined ( p < 0.001), estimating a mean decrease around 0.034 units per month of follow-up.
Furthermore, the division of the series in three segments resulted in non-significant trends in the first two segments (both Bs = 0.0002, p = 0.46 and p = 0.24, respectively) but a significant trend in the phase beginning on June 9 ( B = 0.0003, p < 0.001).
A significant trend ( P < 0.001) further indicated a consistent association between TB-HIV co-infection and treatment status.
Moreover, BNP levels were markedly elevated in patients with HFrEF (589.3 ± 174.2 pg/mL), followed by HFmrEF (386.7 ± 126.3 pg/mL) and HFpEF (242.1 ± 108.4 pg/mL), showing a significant trend across groups ( p < 0.001) (Table 4 ) (Fig. 2 ).
For WC-defined phenotypes, both obesity and metabolic dysfunction independently contributed to increased CVD risk relative to MHN: MHO (RR 1.84, 95% CI: 1.23–2.77), MUN (RR 1.58, 95% CI: 1.14–2.20), and MUO (RR 2.22, 95% CI: 1.63–3.04), with a significant trend across categories ( P < 0.001).