“a significant trend”

After adjustment for age, sex, smoking status, use of antihypertensive medications, and HDL-C levels with the Bonferroni correction, participants carrying the minor alleles of the rs2043085 and rs1532085 genotypes exhibited a significant trend of higher LAP ( P = 3.2 × 10 −6 and 8.1 × 10 −6 for rs2043085 and rs1532085, respectively) and VAI ( P = 4.3 × 10 −6 and 5.2 × 10 −6 for rs2043085 and rs1532085, respectively).

To assess this possibility, we compared delta divergence from the consensus between neighboring ERVs (|neighbor_1_div—neighbor_2_div|) in ERV hotspots to other regions of the genome and report a significant trend in the opposite direction (Mann Whitney U, P = 3.317e−06), suggesting that SD is not the primary contributing mechanism to ERV hotspot formation.

In the OS analysis, patients with higher ZW10 expression exhibited a significant trend toward reduced survival (n = 2976, HR = 1.71 [1.36-2.15], P = 4.6e-06), while lower ZW10 expression levels were associated with a modest improvement in survival.

The result showed that there was a significant trend toward lower incidence in the AlloDerm group ( Fig. 3 ; RR=0.15, 95% CI 0.08–0.30; P<0.00001).

As expected, there was a significant trend for patients with tumours in higher DA to have recurrence earlier than patients with tumours of lower DA (P= 0.00002).

Yet our GRS that was based on known European and Asian POAG SNPs showed a significant trend ( P = 2.81 × 10 −5 ) and a twofold increase in POAG risk comparing extreme risk groups.

Notably, overweight and obese Persians reported a significant trend towards dietary restraint following weight gain compared to Arabs ( P = 4.29 × 10 −5 ), with AMY1 CN showing negative association with dietary self-restraint ( P = 3.22 × 10 −3 ).

In Cox regression, patients with multihit abnormalities had a 2.89-fold increased risk of death compared with those with wild-type TP53 (95% CI, 1.88-4.43), and those with single-hit abnormalities had a 1.63-fold increased risk of death (95% CI, 0.91-2.91) compared with those with wild-type TP53 ( Figure 2 D), with a significant trend in the HR as the number of TP53 abnormalities increased (likelihood ratio test, P = 5.42 × 10 −5 ).

Utilizing bc-GenExMiner v4.0 36 , 37 , we found a significant trend in DEAR1 mRNA downregulation in basal-like tumors compared to other subtypes (p < 0.0001, Supplementary Fig.

A significant trend was seen with an increasing frequency of PIK3CA copy number gain in those with invasive PSCC disease (p<0.0001): PeIN 10/58 (17%) and primary PSCC 84/199 (42%).

Primary outcome The primary outcome of change in FMD of the brachial artery showed a significant trend in the difference among arms from TC to EC-nicotine to EC-nicotine-free (linear trend β for TC, EC-nicotine, EC-nicotine-free = 0.73%; 95% CI: 0.41 to 1.05; p < 0.0001).

A more recent analysis for NHANES 2007–2010 data found a significant trend ( P < 0.0001) toward higher HEI 2010 scores for children who consumed 12 oz of juice/d (HEI = 52.3) than those who did not consume juice (HEI = 43.8) ( 40 ) There are reports that argue fruit juice consumption is comparable with consuming sugar-sweetened beverages that contribute to overweight and obesity, particularly among children ( 41 – 43 ).

There was a significant trend of more recent utilisation of DOACs compared with warfarin (p<0.0001).

There was a significant trend ( P < .0001) for ORs for moderate and poor SCF associated with institutional racism as reported in 1997, based on the domains of housing, jobs, and police.

Among the four primary tumor types described, we observed a significant trend toward improved cPFS with anti-PD1+anti-CTLA4 ICI versus anti-PD1 alone in mucosal melanoma (p=0.0001, figure 4C ).

All five models showed a significant trend ( P < 0.0001) in the relationship between serum Pg IgG Ab levels and early DR risk.

For the five oceans under investigation a significant trend was found (p<0.0001, significance level of 0.05).

There was a significant trend towards outpatient treatment over the study period ( p < 0.0001).

In HEK293 cells with β-arrestin knocked out, there was a significant trend towards increasing the potency when β-arrestins were knocked out ( p < 0.0001) ( Figure 4B , Supplementary Table S6 ).

Comparison of the staining patterns among patients revealed a significant trend towards increased frequency of DFS pattern (ANA associated diseases 10.4%, JIA 21.7% and nonrheumatic conditions 34.8%, p < 0.0001) and decreased frequency of homogenous staining (ANA associated diseases 34.3%, JIA 26.7% and nonrheumatic conditions 8.9%, p < 0.0001) in nonrheumatic conditions.

Simple linear regression on age shows a significant trend towards an increase in the number of TTV genotypes detected in sera as a function of age ( p value < 0.0001; R 2 = 0.02039) ( Figure 4 d).

Pfdhfr There was a significant trend in the decline of wild-type pfdhfr N51/C59/S108 (ptrend; p < 0.0001) allele culminating in the ultimate fixation of the mutant variants in 2012/2013.

There was a significant trend towards a decrease in average ED LOS 282 (standard error of mean [SEM] ± 19) vs 185 (± 13) minutes ( p = 0.0001).

There was a significant trend in survival function across the four groups (χ 2 29.6, P < .0001), the worst outcome being detectable in patients of group 4 (Figure 3 ).

The trend analysis indicated a significant trend across all models (P < 0.0001 in Models 1 and 2, P = 0.003 in Model 3), suggesting that higher levels of PA, as reflected by the MBB index, are associated with a progressively lower risk of ED.