“a significant trend”

For example, a study found a significant trend towards longer objective remission rates (ORR) and overall survival in recurrent OC patients receiving pembrolizumab ( PD-1 inhibitor) monotherapy [10] .

In the tertile analysis, individuals in the highest tertile had more than double the odds of having cardio‐kidney comorbidities compared with those in the lowest tertile (OR = 2.25, 95% CI: 2.10–2.42), with a significant trend across tertiles ( p for trend < 0.001). 3.3.

19 The number of subjects not anticoagulated after ablation for AF or atrial flutter may not have been sufficient to detect a significant trend toward increased incidence of the primary endpoint in this subgroup.

Conflicting results are reported also for the association between PFCs and sperm DNA quality, although a significant trend is evident for increased DNA fragmentation in exposed men [ 117 , 119 , 120 ].

Therefore, the low R 2 values of the predicted lignin degradation and experimental values plots illustrate that a significant trend can be identified even for relatively noisy data with high variability.

However, the T-profiler analysis of the transcriptomic data did not display a significant trend in the expression of these genes ( supplemental Table S14 ).

Furthermore, the DN patient group exhibited a significant trend of upregulating all biomarkers (Fig. 8 A).

The cross did appear to have a lower ratio, however this is more likely attributed to a lower number of samples and the high variation in individual birds than a significant trend.

Marks et al., [ 39 ] demonstrated in their study that the incidence of new perfusion defects increased with larger irradiated LV volumes and higher mean LV doses, showing a significant trend over time.

Significant trends toward higher, positive SPI values exist within the first dry (trend = 0.37; 95% c.l.) and short rains (trend = 0.28; 90% c.l.) season statistics with a significant trend toward abnormally dry conditions within the second dry season (trend = −1.14; 95% c.l.).

Although the scatter between units remains wide, there has been a significant trend towards a higher median performance with time, parti- cularly for the use of inhaled steroids on discharge and for the use of written self-management plans (Fig 2).

A significant trend toward improved long-term survival was observed in women and not in men.

With margins 1–9 mm (score 2), there was a significant trend toward a benefit from irradiation.

A significant trend is the increasing emphasis on producing low-dimensional metal oxide nanostructures, including nanoparticles, nanorods, and nanosheets, by sol–gel methods.

Based on the bibliometric analysis, we found that although clinical applications are still in their infancy, optogenetics is a significant trend for the future and deserves further attention. 5.

On univariate analysis, a significant trend towards higher risk of seropositivity in the areas with higher deprivation was seen, however, this was not statistically significant in the multivariable analysis when using either IDACI and IMD.

A significant trend was found between SES and TCM utilization, even after controlling for many of the relevant associated factors.

For duration of treatment, there was a significant trend over duration categories (p trend =0.03) with the highest adjusted HRs in the group with the longest (≥7 years) treatment duration but only reaching significance in the restricted model and not in the full model (restricted model: HR 1.29, 95% CI: 1.03-1.61; full model: HR 1.23, 95% CI: 0.97-1.55, Table 3 ).

abies TE trees showed a significant trend of decreasing ΔL with time, although only in 2017 ΔL resulted significantly lower than control trees (Figure 7 ). 3.3.

The predicted cancer probability based on the 5-hmC classifier from plasma cfDNA showed a significant trend associated with clinical stage.

These results are consistent with sensitivity analysis, except when analyzing the mediation of diet quality in the association between screen time and CRF, where only a significant trend was observed ( Figures S1 and S2 ). 4.

In our model, 4 weeks post-transplantation, saline treated ApoE −/− GzmB −/− DKO allografts had a significant trend toward reduced plaque area ( Fig. 6A ) and IMT ( Fig. 6B ) when compared to saline treated ApoE −/− allografts ( Fig. 6A ), suggesting that GzmB deficiency in donors has variable effects on plaque growth.

We noted a significant trend for an increase in CTN transection in anatomical types where the CTN emerged above the posterior canaliculus, such as in the “Attached Short type” and “Ultrashort type” (Figure 1 ).

They observed a significant trend for a better overall outcome in subjects who were treated with thiamine compared with those who remained untreated.

We can summarize these results by asking: What is the percentage of the ocean area showing a significant trend at different intervals over the 21st century?